UTMB Clinical and Translational Science Award

UTMB 临床和转化科学奖

• 批准号: 10611942
• 负责人: Randall J Urban
• 金额: $ 277.46万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-18 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10611942
• 关键词: Acceleration; Address; Affect; African American; Age; Characteristics; Clinic; Clinical Research; Clinical Sciences; Clinical Skills; Clinical Trials; Clinical Trials Network; Clinical and Translational Science Awards; Collaborations; Communication; Communities; Country; Course Content; Data; Discipline of Nursing; Diverse Workforce; Education; Educational Curriculum; Effectiveness; Entrepreneurship; Ethnic Origin; Gender; Geriatrics; Goals; Hand; Health; Health Occupations; Health Sciences; Health system; Healthcare Activity; Heterogeneity; Hispanic; Home; Hospitals; Individual; Informatics; Institution; Institutional Review Boards; Leadership; Learning; Longevity; Medical; Methodology; Methods; Minority; Mission; Modeling; Multi-Institutional Clinical Trial; National Center for Advancing Translational Sciences; Native Americans; Outcomes Research; Participant; Patient Care; Patient-Focused Outcomes; Pediatrics; Phase; Population; Pregnancy; Race; Research; Research Personnel; Research Support; Resource Sharing; Resources; Schools; Science; Services; Source; Special Population; Structure; Technology; Testing; Texas; Training; Translation Process; Translational Research; Universities; Work; analytical tool; career; community engagement; comparative effectiveness; data resource; data sharing; design; effective intervention; experience; health goals; improved; informatics infrastructure; informatics training; innovation; inter-institutional; interoperability; knowledge base; medical schools; meetings; multi-site trial; multidisciplinary; novel; operation; patient population; programs; skills; translational pipeline

Contact PD/PI: Urban, Randall J. O. Overall Project Summary The University of Texas Medical Branch (UTMB) has participated as a CTSA hub since 2009. The academic home of our CTSA, the Institute for Translational Sciences (ITS), has brought together multidisciplinary translational teams (MTTs) and the resources necessary to accelerate discoveries toward better health for individuals and communities. Building on our existing strengths, CTSA initiatives have transformed UTMB’s learning and research culture to one that embraces multidisciplinary translational team (MTT) approaches to addressing significant health problems. We have developed novel educational curricula, significant clinical research programs in special populations with multisite clinical trials, and provided leadership in the Texas Regional CTSA consortium (TRCC) and nationally. UTMB’s CTSA hub supports the health goals of the nation by generating, testing and disseminating integrative team science, education and best practices through stakeholder involvement at all stages. Managed by a continuous improvement model using an Innovation Scorecard, we will address six specific aims, to: 1) Expand the knowledge base and practice of collaborative teams to advance the conduct of translational research through team-based innovation. Building on our team science leadership, we will test, learn, and disseminate multi-institutional teaming to enhance the quality, efficiency, effectiveness, and diversity of clinical and translational research. 2) Engage local, regional, and national stakeholders to make research more effective at meeting their needs. We will build upon our relationships to extend inter-institutional partnerships, and to work with stakeholders to disseminate scientific findings and advance the field of community engagement. 3) Harness the potential of harmonized large data platforms across the translational spectrum to improve research efficiency, develop technologies to support research teams, and share resources with researchers across the CTSA network. Our aims are designed to enhance our informatics infrastructure and training with regional and CTSA network interoperability putting existing and novel analytics tools into the hands of users. 4) Promote clinical and translational research across the lifespan including special populations. We will expand upon our significant strengths in multi-site trials in special populations to proactively engage the NCATS Trial Innovation Network for new trials originating from UTMB. 5) Improve training for a diverse workforce in the authentic skills needed to advance all phases of clinical and translational research. Our integrated U, K, and T programs will include participants with diverse professional and educational experience, as well as diverse age, gender, racial, and ethnic characteristics. 6) Develop and disseminate improved methods and processes for translation from discovery to improved health. We will apply a continuous improvement approach to understand barriers, develop effective interventions, and disseminate improvements in translational science and operations. Page 430 Project Summary/Abstract Contact PD/PI: Urban, Randall J. Narrative UTMB’s CTSA Hub will work with local, regional, and national partners to support translational research and accelerate discoveries toward better health. We will train a diverse workforce and build multidisciplinary teams to conduct efficient, high-quality clinical research across the lifespan that includes understudied populations. We will integrate our research and healthcare activities and will generate, apply and share data and best practices across institutions. Page 431

联系人 PD/PI：Urban, Randall J. O、总体 项目概要 德克萨斯大学医学分部 (UTMB) 自 2009 年起作为 CTSA 中心参与其中。学术之家 我们 CTSA 的转化科学研究所 (ITS) 汇集了多学科的转化 团队（MTT）和加速发现以改善个人健康和改善健康所需的资源 社区。基于我们现有的优势，CTSA 举措改变了 UTMB 的学习和研究 一种采用多学科转化团队 (MTT) 方法来解决重大问题的文化 健康问题。我们开发了新颖的教育课程、重要的临床研究项目 特殊人群进行多中心临床试验，并在德克萨斯州地区 CTSA 联盟中发挥领导作用 （TRCC）和全国范围内。 UTMB 的 CTSA 中心通过生成、测试和 通过利益相关者的参与传播综合团队科学、教育和最佳实践 阶段。通过使用创新记分卡的持续改进模型进行管理，我们将解决六个问题 具体目标是： 1) 扩大协作团队的知识库和实践，以推进行为 通过基于团队的创新进行转化研究。建立在我们团队科学领导力的基础上，我们将测试， 学习和传播多机构团队合作，以提高质量、效率、有效性和多样性 临床和转化研究。 2) 让地方、区域和国家利益相关者参与进来，使研究更加深入 有效地满足他们的需求。我们将利用我们的关系来扩大机构间的伙伴关系，并且 与利益相关者合作传播科学发现并推动社区参与。 3） 利用跨转化领域的协调大数据平台的潜力来改进研究 效率，开发技术来支持研究团队，并与整个研究人员共享资源 CTSA 网络。我们的目标是加强我们的信息学基础设施和培训与区域和 CTSA 网络互操作性将现有的和新颖的分析工具交到用户手中。 4) 推广 包括特殊人群在内的整个生命周期的临床和转化研究。我们将扩大我们的 在特殊人群多中心试验方面具有显着优势，积极参与 NCATS 试验创新 来自 UTMB 的新试验网络。 5) 加强对多元化劳动力的真实技能培训 需要推进临床和转化研究的所有阶段。我们的综合大学、K 和 T 课程将 包括具有不同专业和教育经验以及不同年龄、性别、种族、 和民族特色。 6) 开发并传播改进的翻译方法和流程 发现以改善健康。我们将采用持续改进的方法来了解障碍，开发 有效的干预措施，并传播转化科学和操作的改进。 第430页 项目概要/摘要 联系人 PD/PI：Urban, Randall J. 叙述 UTMB 的 CTSA 中心将与当地、区域和国家合作伙伴合作，支持转化研究和 加速发现以改善健康。我们将培训多元化的员工队伍并建立多学科团队 在包括未充分研究的人群在内的整个生命周期中进行高效、高质量的临床研究。 我们将整合我们的研究和医疗保健活动，并生成、应用和共享数据，并以最佳方式 跨机构的实践。 第431页