2022 Photosensory Receptors and Signal Transduction GRC/GRS

2022 光敏感受器和信号转导GRC/GRS

基本信息

批准号：
10377057
负责人：
BRIAN R CRANE
金额：
$ 1.61万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10377057
关键词：
Address Affect American Architecture Area Basic Science Behavior Behavior Disorders Behavior Therapy Behavioral Biological Biological Process Biotechnology Blindness Cell physiology Cells Cellular biology Chemicals Circadian Dysregulation Circadian Rhythms Clinical Collaborations Communities Complex Cryoelectron Microscopy Defect Development Discipline Disease Ecosystem Engineering Equilibrium Event Evolution Eye Faculty Fostering Foundations Future Genetic Goals Human In Vitro Intervention Knowledge Lead Light Link Macromolecular Complexes Macular degeneration Mediating Mentors Mentorship Metagenomics Methodology Methods Microfluidics Microscopy Mission Modernization Molecular Mood Disorders Moods Nature Night Blindness Opsin Organism Participant Pathogenicity Pathway interactions Perception Persons Phenotype Photobiology Photoreceptors Phototransduction Physiology Postdoctoral Fellow Process Receptor Signaling Regulation Research Research Methodology Research Personnel Retinal Degeneration Retinal Diseases Retinitis Pigmentosa Rhodopsin Roentgen Rays Role Scientific Advances and Accomplishments Scientist Sensory Signal Pathway Signal Transduction Signaling Protein Source Specialist Spectrum Analysis Structural Biologist Structure Students System Systems Biology Talents Techniques Training Vision Visual system structure Well in self Work behavioral response biophysical tools cell behavior cellular imaging experience frontier graduate student high throughput screening interest magnetic field meetings microbial molecular imaging new technology next generation novel novel strategies optogenetics particle photonics photosystem posters practical application prevent professional atmosphere programs protein function receptor reconstitution response screening sight restoration single molecule stem supportive environment symposium tomography tool tool development vibration

项目摘要

Summary At the 2022 Photosensory Receptors and Signal Transduction (PRST) Gordon Research Conference (GRC) to be held in Ventura CA, scientists from all over the world gather to present and discuss the full palette of photosensory systems that Nature has provided, aiming to understand their mechanisms, signaling pathways and functional effects – from the level of atoms and molecules to that of the physiology of organisms and the ecosystems that they constitute. Photosensory receptors provide unique opportunities to understand the essential principles of signal transduction and protein function because they can be activated by light, rendering them amenable to state-of-the-art physical, chemical and cell-biological approaches. In this way, the central question of how light-induced molecular changes produce large-scale biological signals can be addressed in unprecedented detail. Research of photosensory signaling has enormous practical application. In the case of vertebrate vision, loss of the finely tuned regulation of the phototransduction pathway has been linked to various types of retinal degeneration that cause conditions such as night blindness, tunnel vision, and even the total loss of sight. Studies of phototransduction in the eye also lead to the treatment of retinal diseases, circadian dysfunction and mood disorders. The modular architecture of photosensory systems in combination with their genetic encodability provides the foundation for the field of optogenetics, wherein photoreceptors and their interaction pathways are engineered to noninvasively control cellular processes with light. Research on photosensory receptors is inherently interdisciplinary, requiring basic scientific advances on several fronts. The themes of the GRC and the associated Gordon Research Seminar (GRS) have been chosen to represent the key interdisciplinary problems in the field and to stimulate the exchange of ideas between a diverse group of researchers. Emerging directions such as the impact of new technologies for understanding receptor photophysics and mechanism, the role macromolecular complexes in transducing complex photonic responses, such as those of vertebrate vision, and the engineering of photosensors for optogenetics will be explored in depth. Invited speakers will include both established and early-stage investigators. In addition, poster presenters will compete for short hot-topic talks. The GRS provides a supportive environment for junior scientists to present their work and receive advise by senior mentors. The PRST community has long supported junior scientists, and the GRS will continue to help us nurture the development of early-stage investigators and promote diversity within our community. The field of photosensory transduction has been undergoing a revitalization due to an influx of talented new researchers who apply advanced tools of biophysics, computation, single molecule or cell imaging and high-throughput screening methods to provide answers previously unattainable. The well-integrated PRST GRC/GRS will scientists to the most important questions confronting our field and will encourage postdocs and students to apply their hard-won training to the most exciting new areas of photobiology.

概括在2022年的光感受体和信号转导（PRST）戈登研究会议（GRC）上在CA举行，来自世界各地的科学家聚集在一起，讨论和讨论的完整调色板大自然提供的光感系统旨在了解其机制，信号通路和功能效应 - 从原子和分子的水平到生物的生理学和生理学的水平它们构成的生态系统。光感受体提供了理解的独特机会信号转导和蛋白质功能的基本原理，因为它们可以通过光线激活，呈现它们适合最先进的物理，化学和细胞生物学方法。这样，中央光引起的分子变化如何产生大规模生物学信号的问题前所未有的细节。光感信号的研究具有巨大的实际应用。如果是脊椎动物的视觉，光转导通路的精细调节调节的丧失与各种导致夜盲，隧道视觉甚至总损失等条件的残留变性类型视线。眼睛中光转导的研究还导致残留疾病的治疗，昼夜节律功能障碍和情绪障碍。光感系统的模块化结构与它们的结合遗传编码为光遗传学领域提供了基础，其中感光体及相互作用途径被设计为非侵入性控制细胞过程。研究光感受体本质上是跨学科的，需要几个方面的基本科学进步。这已经选择了GRC和相关的Gordon Research研讨会（GRS）的主题来代表该领域的关键跨学科问题，并刺激潜水员之间的思想交流研究人员。新兴方向，例如新技术对接收者的影响光体物理学和机制，即大分子复合物在转导复杂光子响应中的作用，例如，将探索脊椎动物视觉和光遗传学光遗传学的工程深度。被邀请的演讲者将包括既定的调查人员和早期调查员。此外，海报演示者将竞争简短的热门谈判。 GRS为初级科学家提供了一个支持环境他们的工作并由高级导师接收顾问。 PRST社区长期以来一直支持初级科学家，并 GRS将继续帮助我们护理早期调查人员的发展并促进多样性在我们的社区内。光感转移的领域由于一个才华横溢的新研究人员的影响成像和高通量筛选方法可提供以前无法实现的答案。整合的 PRST GRC/GRS将科学家处理我们领域面临的最重要问题，并鼓励博士后和学生将他们的硬训练培训应用于最激动人心的光生物学领域。