Research Training in Late-Life NeuroPsychiatric Disorders

项目摘要本申请是为了继续支持(21-26年)T32项目“后期研究培训”。 生活神经精神障碍“。这项提议的主要目标是培养博士后(医学博士、医学博士/博士和 博士)作为晚年神经精神障碍的独立研究人员。在最后 2013年11月的竞争性审查审查员的结论是：“该计划现已进入第15个年头，有许多 重要优势包括结构合理的课程、教师的专业知识和资历范围， 有效的领导和丰富的资源，学员可以通过附属部门和 程序。该计划有一个明确和令人信服的理由，其重点是晚年生活，无论是在临床上 老年人特有的问题以及开展这方面研究的方法和概念上的挑战 年龄段。然而，该项目最令人信服的优势是其毕业生作为 以生产率、学术进步、研究资金和对科学的贡献来衡量。特别是， 该项目在内科科学家中的代表性特别高。 培训方案的成功既体现在受训者的成就上，也体现在 研究人员的多样性。在过去的15年里，28名研究员得到了T32的支持；46%的女性，25%的医学博士， 博士/博士占14%，博士占61%。11%的研究员是代表不足的少数族裔，36%来自 文化或种族背景不是高加索人，也不是北美或欧洲人。这个 毕业率为94%(22/23-1辍学，后来回到哥伦比亚大学研究并获得K 奖项)。在5名尚未毕业的研究员中，4名研究员正在接受培训(1名第三研究员将于18年6月30日毕业，1名 二年级研究员和两名一年级研究员)和一名研究员将于7/1/18开始训练。 在过去的15年里毕业的人中，35%获得了K奖，而在6名完成K奖的研究员中，50%的人获得了K奖 都获得了R奖。三名没有获得K的研究员获得了NARSAD。因此，48%的毕业生 都得到了独立的资助。65%的毕业生在研究密集型岗位，9%在研究-- 相关职位。在过去的20年里，所有奖学金职位都由非常合格的候选人填补。 精神病学系的一项新研究计划创建了大脑老化和心理健康倡议。 这一倡议有两个部门：老年精神病学部，由Devanand博士(导师)领导 专注于轻度认知障碍和阿尔茨海默病的研究。神经生物学和神经生物学系 由布雷特·卢瑟福博士(课程主任)领导的衰老治疗关注的是相互作用 在与衰老相关的过程和晚年精神障碍之间。T32也有一些变化 包括1)加强基础科学和翻译能力的6名新导师，2)修订 统计和研究设计课程3)增加研究员的每月研讨会和中枢神经系统讲座3)增加 研究性课程的负责任行为。

Project Summary This submission is for continued support (years 21-26) of the T32 “Research Training in Late- life Neuropsychiatric Disorders”. The primary goal of this proposal is to train postdoctoral (MD, MD/PhD, and PhD) fellows for careers as independent researchers in Late-Life Neuropsychiatric Disorders. At the last competitive review in Nov 2013 the reviewers concluded that, “The program, now in its fifteenth year, has many important strengths including a well-structured curriculum, the range of expertise and qualifications of the faculty, effective leadership and the wealth of resources accessible to trainees through the affiliated departments and programs. The program has a clear and compelling rationale for its focus on late life, both in terms of clinical problems unique to the elderly and methodological and conceptual challenges in conducting research with this age group. However, the program's most compelling strength is the successful record of its graduates as measured by productivity, academic advancement, research funding, and contributions to science. In particular, the program has had a particularly high representation of physician scientists.” The success of the training program is reflected in both the accomplishments of the trainees and the diversity of the fellows. In the past 15 years, 28 fellows received support from the T32; 46% female, 25% MDs, 14% MD/PhDs and 61% PhDs. 11% of the fellows are under-represented minorities, and 36% come from cultural or ethnic backgrounds that are either not Caucasian or not from North America or Europe. The graduation rate is 94% (22/23 – the 1 drop-out, later came back to research at Columbia and received a K award). Of the 5 fellows not yet graduated, 4 fellows are in training (1 third fellow will graduate on 6/30/18, 1 a second-year fellow, and 2 first year fellows) and one fellow will begin training on 7/1/18. Of the 23 fellows who have graduated in the last 15 years, 35% have received K awards and of 6 fellows who finished their K 50% have received an R award. Three fellows who did not receive a K received a NARSAD. Thus 48% of graduates have received independent funding. 65% of graduates are in research-intensive positions and 9% in research- related positions. In the past 20 years all fellowship positions have been filled with very qualified candidates. A new research plan for the Department of Psychiatry created the Brain Aging and Mental Health initiative. There are two divisions in this initiative; the Division of Geriatric Psychiatry headed by Dr. Devanand (mentor) focuses on studies mild cognitive impairment, and Alzheimer's disease. The division of Neurobiology and Therapeutics of Aging, headed by Dr. Bret Rutherford (Director of Curriculum) focuses on the interplay between aging-associated processes and late-life psychiatric disorders. There are also changes in the T32 including 1) six new mentors that strengthen the basic science and translational faculty, 2) revision in the statistics and research design classes 3) addition of the fellow's monthly seminar and CNS talks 3) additions to the Responsible Conduct of Research curriculum.