Research Training in Late-Life NeuroPsychiatric Disorders

晚年神经精神疾病研究培训

• 批准号: 10591549
• 负责人: Patrick J Brown
• 金额: $ 29.91万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591549
• 关键词: Elderly; Research Training; neuropsychiatric disorder

Project Summary This submission is for continued support (years 21-26) of the T32 “Research Training in Late- life Neuropsychiatric Disorders”. The primary goal of this proposal is to train postdoctoral (MD, MD/PhD, and PhD) fellows for careers as independent researchers in Late-Life Neuropsychiatric Disorders. At the last competitive review in Nov 2013 the reviewers concluded that, “The program, now in its fifteenth year, has many important strengths including a well-structured curriculum, the range of expertise and qualifications of the faculty, effective leadership and the wealth of resources accessible to trainees through the affiliated departments and programs. The program has a clear and compelling rationale for its focus on late life, both in terms of clinical problems unique to the elderly and methodological and conceptual challenges in conducting research with this age group. However, the program's most compelling strength is the successful record of its graduates as measured by productivity, academic advancement, research funding, and contributions to science. In particular, the program has had a particularly high representation of physician scientists.” The success of the training program is reflected in both the accomplishments of the trainees and the diversity of the fellows. In the past 15 years, 28 fellows received support from the T32; 46% female, 25% MDs, 14% MD/PhDs and 61% PhDs. 11% of the fellows are under-represented minorities, and 36% come from cultural or ethnic backgrounds that are either not Caucasian or not from North America or Europe. The graduation rate is 94% (22/23 – the 1 drop-out, later came back to research at Columbia and received a K award). Of the 5 fellows not yet graduated, 4 fellows are in training (1 third fellow will graduate on 6/30/18, 1 a second-year fellow, and 2 first year fellows) and one fellow will begin training on 7/1/18. Of the 23 fellows who have graduated in the last 15 years, 35% have received K awards and of 6 fellows who finished their K 50% have received an R award. Three fellows who did not receive a K received a NARSAD. Thus 48% of graduates have received independent funding. 65% of graduates are in research-intensive positions and 9% in research- related positions. In the past 20 years all fellowship positions have been filled with very qualified candidates. A new research plan for the Department of Psychiatry created the Brain Aging and Mental Health initiative. There are two divisions in this initiative; the Division of Geriatric Psychiatry headed by Dr. Devanand (mentor) focuses on studies mild cognitive impairment, and Alzheimer's disease. The division of Neurobiology and Therapeutics of Aging, headed by Dr. Bret Rutherford (Director of Curriculum) focuses on the interplay between aging-associated processes and late-life psychiatric disorders. There are also changes in the T32 including 1) six new mentors that strengthen the basic science and translational faculty, 2) revision in the statistics and research design classes 3) addition of the fellow's monthly seminar and CNS talks 3) additions to the Responsible Conduct of Research curriculum.

项目摘要本次提交是为了继续支持（21 - 26年）的T32 "研究培训后期- 生活神经精神疾病"。该提案的主要目标是培养博士后（MD，MD/PhD， 博士）研究员的职业生涯作为独立的研究人员在晚年神经精神疾病。在最后 在2013年11月的竞争性审查中，审查人员得出结论，“该计划，现在已经进入第十五个年头，有许多 重要的优势，包括结构良好的课程，专业知识和教师资格的范围， 有效的领导和通过附属部门向受训人员提供的丰富资源， 程序.该计划有一个明确的和令人信服的理由，其重点是晚年，无论是在临床方面， 老年人特有的问题以及在进行这方面的研究时所面临的方法和概念挑战 年龄段然而，该计划最引人注目的优势是其毕业生的成功记录， 以生产力、学术进步、研究资金和对科学的贡献来衡量。特别是， 该计划的医生科学家代表性特别高。" 培训计划的成功体现在受训人员的成就和 研究员的多样性。在过去的15年里，28名研究员得到了T32的支持; 46%的女性，25%的医学博士， 14%的医学博士/博士和61%的博士。11%的研究员是代表性不足的少数民族，36%来自 文化或种族背景，要么不是高加索人，要么不是来自北美或欧洲。的 毕业率是94%（22/23 - 1辍学，后来回到研究在哥伦比亚和收到K 奖）。在尚未毕业的5名研究员中，4名研究员正在接受培训（第三名研究员将于2018年6月30日毕业，1名a 第二年的研究员，和2名第一年的研究员）和一名研究员将于2018年7月1日开始培训。在23名研究员中， 在过去的15年中毕业，35%的人获得了K奖，6名研究员完成了50%的K 获得R奖。三个没有得到K的研究员得到了NARSAD。48%的毕业生 获得独立资助。65%的毕业生在研究密集型职位，9%在研究- 相关职位。在过去20年中，所有研究金职位都由非常合格的候选人填补。 精神病学系的一项新的研究计划创建了大脑衰老和心理健康倡议。 该倡议有两个部门：由Devanand博士（导师）领导的老年精神病学部门 专注于研究轻度认知障碍和阿尔茨海默病。神经生物学和 由Bret Rutherford博士（课程主任）领导的老龄化治疗学专注于相互作用 与衰老相关的过程和晚年精神疾病之间的联系。T32也有变化 包括1）六个新的导师，加强基础科学和翻译教师，2）在修订 统计和研究设计课程3）增加研究员的每月研讨会和CNS会谈3）增加 研究课程的负责任的行为。

项目成果

Bias-contingent attention bias modification and attention control training in treatment of PTSD: a randomized control trial.

• DOI: 10.1017/s0033291718003367
• 发表时间: 2019-10
• 期刊: Psychological medicine
• 影响因子: 6.9
• 作者: Lazarov A;Suarez-Jimenez B;Abend R;Naim R;Shvil E;Helpman L;Zhu X;Papini S;Duroski A;Rom R;Schneier FR;Pine DS;Bar-Haim Y;Neria Y
• 通讯作者: Neria Y

A pilot randomized controlled trial of hearing aids to improve mood and cognition in older adults.

• DOI: 10.1002/gps.5311
• 发表时间: 2020-08
• 期刊: International journal of geriatric psychiatry
• 影响因子: 4
• 作者: Brewster KK;Pavlicova M;Stein A;Chen M;Chen C;Brown PJ;Roose SP;Kim AH;Golub JS;Brickman A;Galatioto J;Kuhlmey M;Rutherford BR
• 通讯作者: Rutherford BR

Development of novel measures for Alzheimer's disease prevention trials (NoMAD).

• DOI: 10.1016/j.cct.2021.106425
• 发表时间: 2021-07
• 期刊: CONTEMPORARY CLINICAL TRIALS
• 影响因子: 2.2
• 作者: Bell, Sophie A.;Cohen, Hannah R.;Lee, Seonjoo;Kim, Hyun;Ciarleglio, Adam;Andrews, Howard;Rivera, Andres M.;Igwe, Kay;Brickman, Adam M.;Devanand, D. P.;Harvey, Philip D.;Schneider, Lon S.;Goldberg, Terry E.
• 通讯作者: Goldberg, Terry E.

Quantitative approaches for assessment of white matter hyperintensities in elderly populations.

• DOI: 10.1016/j.pscychresns.2011.03.007
• 发表时间: 2011-08-30
• 期刊: Psychiatry research
• 影响因子: 11.3
• 作者: Brickman AM;Sneed JR;Provenzano FA;Garcon E;Johnert L;Muraskin J;Yeung LK;Zimmerman ME;Roose SP
• 通讯作者: Roose SP

Gene expression profiling of depression and suicide in human prefrontal cortex.

人类前额皮质抑郁和自杀的基因表达谱。

• DOI: 10.1038/sj.npp.1300335
• 发表时间: 2004
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Sibille,Etienne;Arango,Victoria;Galfalvy,HangaC;Pavlidis,Paul;Erraji-Benchekroun,Loubna;Ellis,SteveP;JohnMann,J
• 通讯作者: JohnMann,J