Core A: Administrative Core

项目摘要--核心A(行政核心) 耶鲁大学TMC的目标是绘制初级(骨髓和胸腺)和次级(扁桃体和胸腺)细胞衰老图 淋巴器官)，这需要组建一支具有不同专业知识的高度多学科的团队 描述和了解人体组织中的细胞衰老和相关环境。这个 管理核心由Fan博士和Halene博士领导，他们有着长期积极合作的记录， 在NIH财团活动和大型团队项目管理方面有丰富的经验。一项计划 经理将协调耶鲁TMC内部的所有行政活动以及与NIH Sennet的沟通 项目工作人员。具体来说，行政核心将履行以下主要职能：(1)建立 领导计划和运营结构，以监督和管理所有研究活动，建立决策- 制定TMC治理程序，建立监督机制，确保内部有效 管理正在进行的研究和参与SENet活动；(2)建立TMC协调 计划包括耶鲁TMC内部核心之间的通信和协作，定义和监控 每个核心的具体职责，管理试点赠款项目，评估进展和里程碑，以及 制定战略，最大限度地减少数据生成和共享中的混杂因素；(3)开发SENet 联合体协调计划，包括参与指导委员会，以改进和实施 操作规程，加入或创建新的兴趣小组，如“空间组学”和“免疫细胞” 承诺与CODCC和其他TMC合作，进行协议和数据集成，并 共享和管理跨网络协作。我们将坚持全网政策和程序 由NIH和Sennet指导委员会建立，包括数据访问、出版和知识产权 财产政策。我们还将遵守《谅解备忘录》和其他分享协议 可能需要在网络和其他相关项目内共享数据和生物武器。这个 行政核心将开展外联活动，以加强广大民众对数据的传播和利用 研究社区以提高我们对细胞衰老、异质性和相关的理解 发育、衰老和疾病方面的环境。

PROJECT SUMMARY – Core A (Administrative Core) Yale TMC aims to map cellular senescence in primary (bone marrow and thymus) and secondary (tonsil and lymph node) lymphoid organs, which requires assembling a highly multidisciplinary team with diverse expertise to characterize and understand cellular senescence and associated environments in human tissues. The Administrative Core is led by Drs. Fan and Halene, whose have a long-standing record of active collaboration, extensive experience in NIH consortium activities, and the management of large team projects. A program manager will coordinate all administrative activities within Yale TMC and the communications with NIH SenNet program staff. Specifically, the Administrative Core will fulfill the following key functions: (1) establish a leadership plan and the operation structure to supervise and manage all research activities, set up a decision- making procedure for the TMC’s governance, establish supervisory mechanisms to ensure effective internal management of ongoing research and participation in SenNet activities; (2) establish the TMC coordination plan including communications and collaborations between the Cores within Yale TMC, define and monitor specific responsibilities of each Core, manage the pilot grant projects, evaluate progress and milestones, and develop strategies to minimize confounding factors in data generation and sharing; (3) develop a SenNet consortium coordination plan including participation in the steering committee to improve and implement operation protocols, joining or creating new interest groups such as “spatial omics” and “immune cell senescence”, make commitment to work with CODCC and other TMCs for protocol and data integration and sharing, and mange trans-network collaborations. We will adhere to Network-wide policies and procedures established by the NIH and the SenNet Steering Committee, including data access, publication, and intellectual property policies. We will also abide by, Memoranda of Understanding and other sharing agreements potentially needed for data and biospecimen sharing within the Network and other related programs. The Administrative Core will develop outreach activities to enhance data dissemination and utilization by the large research community to improve our understanding of cellular senescence, heterogeneity and associated environments in development, aging, and disease.