Core A: Administrative Core

项目摘要 – 核心 A（管理核心） 耶鲁大学 TMC 旨在绘制初级细胞（骨髓和胸腺）和次级细胞（扁桃体和胸腺）的细胞衰老图谱。 淋巴结）淋巴器官，这需要组建具有不同专业知识的高度多学科团队 表征和理解人体组织中的细胞衰老和相关环境。的 行政核心由博士领导。 Fan 和 Halene 有着长期的积极合作记录， 在 NIH 联盟活动和大型团队项目管理方面拥有丰富的经验。一个程序 经理将协调耶鲁 TMC 内的所有行政活动以及与 NIH SenNet 的沟通 节目人员。具体来说，行政核心将履行以下主要职能：（1）建立一个 领导计划和运作结构来监督和管理所有研究活动，设立决策机构 制定TMC治理程序，建立监督机制，确保内部有效 管理正在进行的研究和参与 SenNet 活动； (2)建立TMC协调 制定计划，包括耶鲁 TMC 核心之间的沟通和协作、定义和监控 每个核心的具体职责，管理试点拨款项目，评估进展和里程碑，以及 制定策略，尽量减少数据生成和共享中的混杂因素； (3)开发SenNet 联合体协调计划，包括参与指导委员会以改进和实施 操作协议，加入或创建新的兴趣小组，例如“空间组学”和“免疫细胞” 衰老”，承诺与 CODCC 和其他 TMC 合作进行协议和数据集成， 共享和管理跨网络协作。我们将遵守全网络的政策和程序 由 NIH 和 SenNet 指导委员会建立，包括数据访问、出版和知识产权 房产政策。我们还将遵守谅解备忘录和其他共享协议 网络和其他相关计划内的数据和生物样本共享可能需要。的 行政核心将开展外展活动，以加强大数据的传播和利用 研究界提高我们对细胞衰老、异质性和相关的理解 发育、衰老和疾病的环境。

PROJECT SUMMARY – Core A (Administrative Core) Yale TMC aims to map cellular senescence in primary (bone marrow and thymus) and secondary (tonsil and lymph node) lymphoid organs, which requires assembling a highly multidisciplinary team with diverse expertise to characterize and understand cellular senescence and associated environments in human tissues. The Administrative Core is led by Drs. Fan and Halene, whose have a long-standing record of active collaboration, extensive experience in NIH consortium activities, and the management of large team projects. A program manager will coordinate all administrative activities within Yale TMC and the communications with NIH SenNet program staff. Specifically, the Administrative Core will fulfill the following key functions: (1) establish a leadership plan and the operation structure to supervise and manage all research activities, set up a decision- making procedure for the TMC’s governance, establish supervisory mechanisms to ensure effective internal management of ongoing research and participation in SenNet activities; (2) establish the TMC coordination plan including communications and collaborations between the Cores within Yale TMC, define and monitor specific responsibilities of each Core, manage the pilot grant projects, evaluate progress and milestones, and develop strategies to minimize confounding factors in data generation and sharing; (3) develop a SenNet consortium coordination plan including participation in the steering committee to improve and implement operation protocols, joining or creating new interest groups such as “spatial omics” and “immune cell senescence”, make commitment to work with CODCC and other TMCs for protocol and data integration and sharing, and mange trans-network collaborations. We will adhere to Network-wide policies and procedures established by the NIH and the SenNet Steering Committee, including data access, publication, and intellectual property policies. We will also abide by, Memoranda of Understanding and other sharing agreements potentially needed for data and biospecimen sharing within the Network and other related programs. The Administrative Core will develop outreach activities to enhance data dissemination and utilization by the large research community to improve our understanding of cellular senescence, heterogeneity and associated environments in development, aging, and disease.