Low Cost Spectroscopic OCT for GI Applications

适用于 GI 应用的低成本光谱 OCT

• 批准号: 10384636
• 负责人: William Brown
• 金额: $ 25.63万
• 依托单位: LUMEDICA, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2022-12-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10384636
• 关键词: Address; Biomedical Engineering; Biopsy; Cancerous; Categories; Clinical; Colon; Colonic Polyps; Colonoscopes; Colonoscopy; Colorectal; Colorectal Cancer; Colorectal Polyp; Development; Device or Instrument Development; Diagnosis; Diagnostic; Disease; Disease Progression; Endoscopes; Endoscopy; Engineering; Epithelial; General Population; Goals; Health; Health Status; Housing; Image; Imaging Device; Industrialization; Inflammatory Bowel Diseases; Intestines; Learning; Left; Measurement; Methods; Monitor; Mucous Membrane; Optical Coherence Tomography; Optics; Outcome; Pathologist; Pathway interactions; Patients; Performance; Physicians; Polyps; Precancerous Polyp; Price; Procedures; Property; Research; Research Project Grants; Resected; Resolution; Sales; Scanning; Scientist; Small Business Technology Transfer Research; Specificity; Speed; Stains; Structure; Surveillance Methods; System; Techniques; Technology; Three-Dimensional Image; Tissues; Translating; Translations; Uncertainty; Waxes; absorption; adenoma; base; commercialization; cost; design; disorder risk; experience; human tissue; implementation cost; improved; in vivo; instrument; instrumentation; interest; microscopic imaging; novel; premalignant; programs; research study; screening; standard of care; systems research; tool

Project Summary The overall objective of this research project is to develop a low cost implementation of spectroscopic optical coherence tomography (SOCT) for the purpose of evaluating colonic polyps or tissues during colonoscopy procedures. According to current standard of care, colonic polyps are removed by the endoscopist, and then fixed, stained and sectioned before being diagnosed by a pathologist. Here we propose to use SOCT to allow the physician to better identify potentially precancerous polyps or tissues during the endoscopic procedure. To meet this objective, we propose to create an OCT system suitable for use during colonoscopy based on Lumedica’s proprietary OCT engine technology. Lumedica’s OCT systems are designed to provide high performance at low cost but also enable easily configurable parameters, such as imaging speed, imaging resolution and depth. For this project a novel scanning probe will be designed that can be deployed during colonoscopy, and yet is inexpensive enough to be single-use, i.e. disposable. The probe will also be designed to fit in with the standard workflow of endoscopy. Instead of requiring the use of the biopsy channel of the colonoscope for access, the low cost OCT GI probe will be affixed to the outer housing of the endoscope, allowing the physician to examine regions of interest and then acquire a biopsy or remove a polyp without removing the OCT probe. Finally, we will extend clinical utility by expanding the spectral range of the low cost OCT system to permit use of SOCT to obtain functional information by quantitatively analyzing the scattering and absorption properties of the tissue as a means to improve diagnosis. To achieve this goal, we propose the following specific aims: 1) Instrument development: We will implement a new OCT instrument for examination of colorectal polyps with potential for commercial translation to clinical use. The instrument will include a low cost OCT engine, upgraded to enable spectroscopic OCT measurements and a novel probe design that is sufficiently inexpensive to be single use. The probe design will be different from previous OCT efforts, using an approach which fits into the endoscopic workflow by avoiding the need to insert and retract the probe for measurements. 2) SOCT tissue studies: The new SOCT instrument will be applied to examination of resected colon polyps to identify optical spectroscopic signatures of pre-malignancy or adenomas. The probe will be also be applied during endoscopic procedures to validate its ability to interface with the colonic mucosa while also permitting a collocated biopsy to be acquired. Achieving these specific aims will demonstrate feasibility of low cost SOCT for evaluating colorectal epithelial tissues and provide justification for further commercial development.

项目摘要 该研究项目的总体目的是开发光谱光学的低成本实施 相干断层扫描（SOCT），目的是在结肠镜检查过程中评估结肠息肉或组织 程序。根据当前的护理标准，内窥镜消除结肠息肉，然后 在被病理学家诊断之前固定，染色和切片。在这里，我们建议使用SOCT允许 在内窥镜手术过程中，物理学人可以更好地识别潜在的癌性息肉或组织。 为了满足这一目标，我们建议创建一个基于结肠镜检查期间使用的OCT系统 Lumedica的专有OCT发动机技术。 Lumedica的OCT系统旨在提供高 低成本的性能，但也可以启用易于配置的参数，例如成像速度，成像 分辨率和深度。对于这个项目，将设计一个新颖的扫描探针 结肠镜检查，但很便宜，可以一次性，即一次性。探针也将设计 适合内窥镜的标准工作流程。而不是需要使用活检渠道 结肠镜的通道，低成本OCT GI探针将固定在内窥镜的外壳上，允许 物理检查感兴趣的区域，然后进行活检或去除息肉，而无需去除息肉 OCT探针。最后，我们将通过扩展低成本OCT系统的光谱范围来扩展临床实用性 通过定量分析散射和滥用，允许使用SOCT获得功能信息 组织的特性作为改善诊断的手段。为了实现这一目标，我们提出以下特定的特定 目的：1）仪器开发：我们将实施一种新的OCT仪器，以检查结直肠息肉 具有商业翻译为临床使用的潜力。该仪器将包括低成本的OCT发动机， 升级以实现光谱OCT测量和一种足够便宜的新型探针设计 单一使用。探针设计将与以前的10月份不同，使用适合 内窥镜工作流程避免需要插入和缩回探针以进行测量。 2）肥皂组织 研究：新的SOCT仪器将用于检查切除的结肠息肉以识别光学 预防或腺瘤的光谱特征。内镜期间还将应用探针 验证其与结肠粘膜互动能力的过程，同时还允许共同的活检 被收购。实现这些特定目标将证明低成本SOCT的可行性用于评估结直肠 上皮组织并为进一步的商业发展提供理由。

项目成果

Spectroscopic optical coherence tomography for classification of colorectal cancer in a mouse model.

光谱光学相干断层扫描用于小鼠模型中结直肠癌的分类。

• DOI: 10.1002/jbio.202100387
• 发表时间: 2022
• 期刊: Journal of biophotonics
• 影响因子: 2.8
• 作者: Kendall,WesleyY;Bordas,Julianna;Mirminachi,Seyedbabak;Joseph,Abel;Roper,Jatin;Wax,Adam
• 通讯作者: Wax,Adam