Low Cost Spectroscopic OCT for GI Applications

适用于 GI 应用的低成本光谱 OCT

• 批准号: 10384636
• 负责人: William Brown
• 金额: $ 25.63万
• 依托单位: LUMEDICA, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2022-12-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10384636
• 关键词: Address; Biomedical Engineering; Biopsy; Cancerous; Categories; Clinical; Colon; Colonic Polyps; Colonoscopes; Colonoscopy; Colorectal; Colorectal Cancer; Colorectal Polyp; Development; Device or Instrument Development; Diagnosis; Diagnostic; Disease; Disease Progression; Endoscopes; Endoscopy; Engineering; Epithelial; General Population; Goals; Health; Health Status; Housing; Image; Imaging Device; Industrialization; Inflammatory Bowel Diseases; Intestines; Learning; Left; Measurement; Methods; Monitor; Mucous Membrane; Optical Coherence Tomography; Optics; Outcome; Pathologist; Pathway interactions; Patients; Performance; Physicians; Polyps; Precancerous Polyp; Price; Procedures; Property; Research; Research Project Grants; Resected; Resolution; Sales; Scanning; Scientist; Small Business Technology Transfer Research; Specificity; Speed; Stains; Structure; Surveillance Methods; System; Techniques; Technology; Three-Dimensional Image; Tissues; Translating; Translations; Uncertainty; Waxes; absorption; adenoma; base; commercialization; cost; design; disorder risk; experience; human tissue; implementation cost; improved; in vivo; instrument; instrumentation; interest; microscopic imaging; novel; premalignant; programs; research study; screening; standard of care; systems research; tool

Project Summary The overall objective of this research project is to develop a low cost implementation of spectroscopic optical coherence tomography (SOCT) for the purpose of evaluating colonic polyps or tissues during colonoscopy procedures. According to current standard of care, colonic polyps are removed by the endoscopist, and then fixed, stained and sectioned before being diagnosed by a pathologist. Here we propose to use SOCT to allow the physician to better identify potentially precancerous polyps or tissues during the endoscopic procedure. To meet this objective, we propose to create an OCT system suitable for use during colonoscopy based on Lumedica’s proprietary OCT engine technology. Lumedica’s OCT systems are designed to provide high performance at low cost but also enable easily configurable parameters, such as imaging speed, imaging resolution and depth. For this project a novel scanning probe will be designed that can be deployed during colonoscopy, and yet is inexpensive enough to be single-use, i.e. disposable. The probe will also be designed to fit in with the standard workflow of endoscopy. Instead of requiring the use of the biopsy channel of the colonoscope for access, the low cost OCT GI probe will be affixed to the outer housing of the endoscope, allowing the physician to examine regions of interest and then acquire a biopsy or remove a polyp without removing the OCT probe. Finally, we will extend clinical utility by expanding the spectral range of the low cost OCT system to permit use of SOCT to obtain functional information by quantitatively analyzing the scattering and absorption properties of the tissue as a means to improve diagnosis. To achieve this goal, we propose the following specific aims: 1) Instrument development: We will implement a new OCT instrument for examination of colorectal polyps with potential for commercial translation to clinical use. The instrument will include a low cost OCT engine, upgraded to enable spectroscopic OCT measurements and a novel probe design that is sufficiently inexpensive to be single use. The probe design will be different from previous OCT efforts, using an approach which fits into the endoscopic workflow by avoiding the need to insert and retract the probe for measurements. 2) SOCT tissue studies: The new SOCT instrument will be applied to examination of resected colon polyps to identify optical spectroscopic signatures of pre-malignancy or adenomas. The probe will be also be applied during endoscopic procedures to validate its ability to interface with the colonic mucosa while also permitting a collocated biopsy to be acquired. Achieving these specific aims will demonstrate feasibility of low cost SOCT for evaluating colorectal epithelial tissues and provide justification for further commercial development.

项目摘要 本研究项目的总体目标是开发一种低成本的光谱光学实现， 相干断层扫描（SOCT），用于在结肠镜检查期间评价结肠息肉或组织 程序.根据目前的护理标准，结肠息肉由内窥镜医生切除，然后 固定、染色和切片，然后由病理学家进行诊断。在这里，我们建议使用SOCT来允许 医生可以在内窥镜检查过程中更好地识别潜在的癌前息肉或组织。 为了实现这一目标，我们建议创建一个适合在结肠镜检查过程中使用的OCT系统， Lumedica专有的OCT引擎技术。Lumedica的OCT系统旨在提供高质量的 性能低成本，而且还可以轻松配置参数，如成像速度，成像速度， 分辨率和深度。对于该项目，将设计一种新型扫描探头， 结肠镜检查，并且还足够便宜以是单次使用的，即一次性的。探测器还将被设计成 以适应内窥镜检查的标准工作流程。代替需要使用活检装置的活检通道， 低成本OCT GI探头将固定在内窥镜的外壳上， 医生检查感兴趣的区域，然后获取活组织检查或在不去除息肉的情况下去除息肉。 OCT探头。最后，我们将通过扩展低成本OCT系统的光谱范围来扩展临床实用性 允许使用SOCT通过定量分析散射和吸收来获得功能信息 组织的特性作为改善诊断的手段。为实现这一目标，我们提出以下具体建议： 目的：1）仪器开发：我们将实施一种新的OCT仪器，用于检查结直肠息肉 具有商业转化为临床应用的潜力。该仪器将包括一个低成本的OCT引擎， 升级以实现光谱OCT测量和足够便宜的新颖探针设计 为一次性使用。探头设计将与之前的OCT工作不同，使用适合 通过避免插入和缩回探头进行测量的需要，简化了内窥镜工作流程。2)SOCT组织 研究：新的SOCT仪器将应用于检查切除的结肠息肉，以识别光学 癌前病变或腺瘤的光谱特征。该探头也将在内窥镜检查期间应用 验证其与结肠粘膜接触的能力，同时还允许进行同位活检， 被收购。实现这些具体目标将证明低成本SOCT用于评价结直肠癌的可行性 上皮组织，并为进一步的商业开发提供依据。

项目成果

Spectroscopic optical coherence tomography for classification of colorectal cancer in a mouse model.

光谱光学相干断层扫描用于小鼠模型中结直肠癌的分类。

• DOI: 10.1002/jbio.202100387
• 发表时间: 2022
• 期刊: Journal of biophotonics
• 影响因子: 2.8
• 作者: Kendall,WesleyY;Bordas,Julianna;Mirminachi,Seyedbabak;Joseph,Abel;Roper,Jatin;Wax,Adam
• 通讯作者: Wax,Adam