Low Cost Spectroscopic OCT for GI Applications

项目摘要 该研究项目的总体目标是开发一种低成本的光谱光学实现 相干断层扫描(SOCT)在结肠镜检查中评估结肠息肉或组织的价值 程序。根据目前的护理标准，结肠息肉由内窥镜医生切除，然后 固定，染色和切片，然后由病理学家诊断。在这里，我们建议使用SOCT来允许 内科医生在内窥镜手术期间更好地识别潜在的癌前息肉或组织。 为了达到这一目标，我们建议创建一种适合在结肠镜检查中使用的OCT系统，基于 Lumedica拥有专利的OCT发动机技术。Lumedica的OCT系统旨在提供高性能 低成本的性能，还支持轻松配置的参数，如成像速度、成像 分辨率和深度。对于这个项目，将设计一种新型的扫描探头，可以在 结肠镜检查，但便宜到可以一次性使用，即一次性使用。探测器也将被设计成 以适应内窥镜检查的标准工作流程。而不是要求使用 为了接近结肠镜，低成本的OCT GI探头将被固定在内窥镜的外壳上，允许 医生检查感兴趣的区域，然后进行活检或在不切除息肉的情况下切除息肉 OCT探测器。最后，我们将通过扩大低成本OCT系统的光谱范围来扩大临床应用 允许使用SOCT通过定量分析散射和吸收来获得功能信息 组织的特性作为提高诊断的一种手段。为了实现这一目标，我们提出了以下具体建议 目标：1)仪器开发：我们将实施一种新的OCT大肠息肉检查仪器 具有商业转化为临床应用的潜力。该仪器将包括一个低成本的OCT发动机， 升级以支持光谱OCT测量和足够便宜的新型探头设计 一次性使用。探测器的设计将不同于之前的OCT努力，使用一种适合于 通过避免插入和收回探头以进行测量，从而简化了内窥镜工作流程。2)SOCT组织 研究：新的SOCT仪器将应用于切除的结肠息肉的检查，以识别光学 癌前病变或腺瘤的光谱征象。该探头也将在内窥镜检查过程中使用 验证其与结肠粘膜对接能力的程序，同时还允许并置活检以 被收购。这些具体目标的实现将证明低成本SOCT用于评估结直肠的可行性 并为进一步的商业开发提供了理由。

Project Summary The overall objective of this research project is to develop a low cost implementation of spectroscopic optical coherence tomography (SOCT) for the purpose of evaluating colonic polyps or tissues during colonoscopy procedures. According to current standard of care, colonic polyps are removed by the endoscopist, and then fixed, stained and sectioned before being diagnosed by a pathologist. Here we propose to use SOCT to allow the physician to better identify potentially precancerous polyps or tissues during the endoscopic procedure. To meet this objective, we propose to create an OCT system suitable for use during colonoscopy based on Lumedica’s proprietary OCT engine technology. Lumedica’s OCT systems are designed to provide high performance at low cost but also enable easily configurable parameters, such as imaging speed, imaging resolution and depth. For this project a novel scanning probe will be designed that can be deployed during colonoscopy, and yet is inexpensive enough to be single-use, i.e. disposable. The probe will also be designed to fit in with the standard workflow of endoscopy. Instead of requiring the use of the biopsy channel of the colonoscope for access, the low cost OCT GI probe will be affixed to the outer housing of the endoscope, allowing the physician to examine regions of interest and then acquire a biopsy or remove a polyp without removing the OCT probe. Finally, we will extend clinical utility by expanding the spectral range of the low cost OCT system to permit use of SOCT to obtain functional information by quantitatively analyzing the scattering and absorption properties of the tissue as a means to improve diagnosis. To achieve this goal, we propose the following specific aims: 1) Instrument development: We will implement a new OCT instrument for examination of colorectal polyps with potential for commercial translation to clinical use. The instrument will include a low cost OCT engine, upgraded to enable spectroscopic OCT measurements and a novel probe design that is sufficiently inexpensive to be single use. The probe design will be different from previous OCT efforts, using an approach which fits into the endoscopic workflow by avoiding the need to insert and retract the probe for measurements. 2) SOCT tissue studies: The new SOCT instrument will be applied to examination of resected colon polyps to identify optical spectroscopic signatures of pre-malignancy or adenomas. The probe will be also be applied during endoscopic procedures to validate its ability to interface with the colonic mucosa while also permitting a collocated biopsy to be acquired. Achieving these specific aims will demonstrate feasibility of low cost SOCT for evaluating colorectal epithelial tissues and provide justification for further commercial development.