Low Cost OCT Angiography with Spectroscopic Contrast

项目摘要 本研究计画的总体目标是开发一种低成本的光学相干实现方法 断层扫描血管造影术（OCTA）。为了实现这一目标，我们建议将几个新的OCT 组件和技术到一个新的OCTA仪器，可应用于研究，并提供 商业化和临床应用的途径。该成像系统将使用 我们的低成本OCT引擎，这使我们能够提供第一个商业OCT研究系统的销售， 价格低于10，000美元。对于这个项目，我们将实现更快的扫描，高达80 kHz的A扫描速率， 实现增强OCTA扫描采集效率并扩展 我们的OCT系统允许使用光谱信息来测量血氧。 OCTA作为荧光素血管造影的替代方法，在评估视网膜血管方面最受关注 (FA)因为它避免了对荧光造影剂的需要。低成本的OCTA可以扩大OCTA的应用范围， 在有症状的患者中进行视网膜疾病诊断之外的技术，包括更广泛的患者筛查。为 在这个项目中，我们特别感兴趣的是在眼科以外的领域开发OCTA的用例， 包括评估组织灌注和神经缺陷。我们试图证明一个低的可行性， 成本OCTA系统，适合商业化。为了实现这一目标，以下具体目标是 建议：1.开发低成本OCTA发动机和分析软件。2.添加光谱信息 OCTA和3。通过体内试验研究测试和验证OCTA系统。在这个项目完成后，我们将 已经证明了低成本OCTA用于血管网络结构和功能成像的可行性 并为进一步的商业开发提供了理由。

Project Summary The overall objective of this research project is to develop a low cost implementation of optical coherence tomography based angiography (OCTA). To meet this objective, we propose to incorporate several novel OCT components and techniques into a new OCTA instrument which can be applied in research studies and offers a pathway for commercialization and clinical use. This imaging system will use the agile design capabilities of our low cost OCT engine, which has enabled us to offer the first commercial OCT research system for sale at a price under $10,000. For this project we will implement faster scanning, up to A-scan rates of 80 kHz, implement scan patterns that enhance efficiency of OCTA scan acquisition and expand the spectral range of our OCT system to permit use of spectroscopic information to measure blood oxygenation. OCTA has seen the most interest in assessing retinal vasculature as an alternative to fluorescein angiography (FA) as it avoids the need for a fluorescent contrast agent. Low cost OCTA could expand application of the technique beyond diagnosis of retinal disease in patients with symptoms to include wider patient screening. For this project, we are particularly interested in developing use cases for OCTA in fields beyond ophthalmology, including assessing tissue perfusion and neurological defects. We seek to demonstrate the feasibility of a low cost OCTA system that is suitable for commercialization. To reach this goal, the following Specific Aims are proposed: 1. Development of low cost OCTA engine and analysis software. 2. Adding spectroscopic information to OCTA and 3. Test and validate OCTA system with in vivo pilot studies. Upon completion of this project we will have demonstrated the feasibility of a low cost OCTA for structural and functional imaging of vascular networks and provided justification for further commercial development.