Low cost retinal optical coherence tomography for point of care use

用于护理点使用的低成本视网膜光学相干断层扫描

• 批准号: 9515362
• 负责人: William Brown
• 金额: $ 2.5万
• 依托单位: LUMEDICA, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9515362
• 关键词: Android; Antirrhinum; Architecture; Caring; Clinic; Clinical; Collimator; Computer Systems; Computer software; Cornea; Custom; Dermatologic; Dermatology; Detection; Developing Countries; Devices; Diabetic Retinopathy; Diagnostic; Environment; Eye; Gastroenterology; Glaucoma; Goals; Humidity; Image; Liquid substance; Macular degeneration; Mechanics; Monitor; Neurology; Ophthalmologist; Ophthalmology; Optical Coherence Tomography; Optics; Output; Patients; Performance; Phase; Phonation; Physicians; Point-of-Care Systems; Price; Process; Provider; Pupil; Research; Retina; Retinal; Retinopathy of Prematurity; Risk; Sampling; Scanning; Shock; Signal Transduction; Small Business Innovation Research Grant; Speed; Standardization; Structure; System; Tablets; Telephone; Temperature; Testing; arm; base; clinical application; conditioning; cost; design; eye center; fovea centralis; imaging capabilities; imaging system; innovation; instrument; laptop; lens; medical specialties; novel; oncology; optical imaging; point of care; portability; prototype; public health relevance; signal processing; solid state; system architecture; tissue phantom; tool; vibration

 DESCRIPTION (provided by applicant): The objective of this research is to create a clinical prototype of a new optical coherence tomography (OCT) system for use in point of care settings. The target system price will be one third the price of currently available research OCT system while providing system performance comparable to other entry level OCT imaging systems. By breaking the $10,000 system barrier we will provide an incisive tool that will be disruptive to the market by making OCT accessible to most clinics. We have spoken with ophthalmologists who confirm the need for this system in the detection and monitoring of diabetic retinopathy, glaucoma, retinopathy of prematurity, and macular degeneration. Ophthalmology is the first clinical target but we have talked to users from other specialties including, ENT, oncology, dermatology, neurology, and gastroenterology. By significantly reducing instrument cost, this OCT system will be affordable for use at the point of care and in a wide range of research applications. This price point also opens markets in developing countries where the value of clinical OCT is understood, but currently clinical systems are too expensive. The research plan, proposed here, will create a prototype of the low cost instrument that utilizes an innovative system architecture based on newly available components while delivering all the imaging capabilities of OCT. We propose to achieve the following milestones: (1) Implement sub-systems as portable components, (2) Integrate sub-systems and software, and (3) Validate and test the complete portable system using an OCT eye phantom.

 描述（由适用提供）：这项研究的目的是创建新的光学相干断层扫描（OCT）系统的临床原型，以便在护理环境中使用。目标系统价格将是当前可用研究OCT系统价格的三分之一，同时提供与其他入门级OCT成像系统相当的系统性能。通过打破10,000美元的系统障碍，我们将提供一种尖锐的工具，通过使大多数诊所的OCT可以使用，该工具将破坏市场。我们已经与眼科医生进行了交谈，他们在检测和监测糖尿病性视网膜病，青光眼，早产性视网膜病和黄斑变性时确认了该系统的需求。眼科是第一个临床目标，但我们已经与其他专业的用户进行了交谈，包括ENT，肿瘤学，皮肤病学，神经病学和胃肠病学。通过大大降低仪器成本，该OCT系统将在护理点和广泛的研究应用中负担得起。这个价格点也在了解临床OCT价值的发展中国家开放，但目前临床系统太昂贵。这里提出的研究计划将创建低成本工具的原型，该原型利用基于新可用组件的创新系统体系结构，同时提供OCT的所有成像功能。我们建议实现以下里程碑：（1）将子系统作为便携式组件，（2）集成子系统和软件，以及（3）使用OCT EYE PHANTOM验证和测试完整的便携式系统。