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Research Supplement for Kennelia Mellanson

肯尼莉亚·梅兰森的研究增刊

基本信息

批准号：
10382622
负责人：
Helene D Benveniste
金额：
$ 5.71万
依托单位：
STATE UNIVERSITY NEW YORK STONY BROOK
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2022-08-31
项目状态：
已结题

项目摘要

ABSTRACT Here we apply for a research supplement to our R01 grant from the NIA, submitting it in response to PA-21-071 which is directed at fostering diversity in scientific research workforce and developing the careers of eligible investigators. We present a detailed plan to advance the professional career of Kennelia Mellanson, a graduate student in the laboratory. Kennelia’s current project focuses on novel quantitative approaches to determine the key components of the ventricular and glymphatic system of transport in the brain – the ciliary beat, the directional flow of the cerebrospinal fluid (CSF), and the structure of the brain ependymal layer – features that are critical for the efficient ventricular transport of the CSF, and the structure of the aquaporin 4 (AQP4) channels, which serve as the key components of the glymphatic system of transport. Our proposal is in full alignment with the original R01 grant from the NIA “Glymphatic and CSF systems in aging and Alzheimer’s disease”, which focuses on the mechanisms of the brain tissue homeostasis and clearance in Alzheimer's. We now propose using our new techniques and findings on the ventricular and glymphatic transport to determine the changes accompany aging and progression of the Alzheimer's disease in a mouse model and to use this project as a platform for helping and directing Kennelia Mellanson in developing her career as a researcher and a scholar. We present a detailed plan for Kennelia’s professional development, including a detailed plan and timeline for mentorship, manuscript and grant writing, didactic activities, improving the presentation skills, participation in meetings and courses, and networking. Furthermore, we present a research plan for studying the key components of the transport systems that may be compromised by aging and by Alzheimer's disease.

摘要

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Spatiotemporal 3D image registration for mesoscale studies of brain development.

时空3D图像登记，用于脑发育中尺度研究。

DOI：
10.1038/s41598-022-06871-8
发表时间：
2022-03-07
期刊：
Scientific reports
影响因子：
4.6
作者：
Shuvaev S;Lazutkin A;Kiryanov R;Anokhin K;Enikolopov G;Koulakov AA
通讯作者：
Koulakov AA

The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum.

DOI：
10.1007/s00418-021-02048-y
发表时间：
2022-02
期刊：
HISTOCHEMISTRY AND CELL BIOLOGY
影响因子：
2.3
作者：
Maltsev, Dmitry I.;Mellanson, Kennelia A.;Belousov, Vsevolod V.;Enikolopov, Grigori N.;Podgorny, Oleg V.
通讯作者：
Podgorny, Oleg V.

Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain.

DOI：
10.1152/physiol.00015.2022
发表时间：
2022-11-01
期刊：
Physiology (Bethesda, Md.)
影响因子：
0
作者：
Zhao, Lucy;Tannenbaum, Allen;Benveniste, Helene
通讯作者：
Benveniste, Helene

DOI：
10.3389/fnins.2023.1232670
发表时间：
2023
期刊：
FRONTIERS IN NEUROSCIENCE
影响因子：
4.3
作者：
Amelchenko, Evgeny M.;Bezriadnov, Dmitri V.;Chekhov, Olga A.;Anokhin, Konstantin V.;Lazutkin, Alexander A.;Enikolopov, Grigori
通讯作者：
Enikolopov, Grigori

NTnC-like genetically encoded calcium indicator with a positive and enhanced response and fast kinetics.

DOI：
10.1038/s41598-018-33613-6
发表时间：
2018-10-15
期刊：
Scientific reports
影响因子：
4.6
作者：
Barykina NV;Doronin DA;Subach OM;Sotskov VP;Plusnin VV;Ivleva OA;Gruzdeva AM;Kunitsyna TA;Ivashkina OI;Lazutkin AA;Malyshev AY;Smirnov IV;Varizhuk AM;Pozmogova GE;Piatkevich KD;Anokhin KV;Enikolopov G;Subach FV
通讯作者：
Subach FV