Research Supplement for Kennelia Mellanson
肯尼莉亚·梅兰森的研究增刊
基本信息
- 批准号:10382622
- 负责人:
- 金额:$ 5.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-09-15 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAgingAlzheimer&aposs DiseaseAnimal ModelBrainBrain MassCerebral VentriclesCerebrospinal FluidComplexDevelopmentFosteringGrantHomeostasisLaboratoriesManuscriptsMentorshipNervous system structureResearchResearch PersonnelStructureSystemTechniquesTimeLineVentricularWritingaquaporin 4brain healthbrain tissuecareercerebrospinal fluid flowglymphatic systemgraduate studentimprovedmeetingsmouse modelnovelresponseskillssoluteventricular systemwasting
项目摘要
ABSTRACT
Here we apply for a research supplement to our R01 grant from the NIA, submitting it in response to
PA-21-071 which is directed at fostering diversity in scientific research workforce and developing the
careers of eligible investigators. We present a detailed plan to advance the professional career of
Kennelia Mellanson, a graduate student in the laboratory. Kennelia’s current project focuses on novel
quantitative approaches to determine the key components of the ventricular and glymphatic system of
transport in the brain – the ciliary beat, the directional flow of the cerebrospinal fluid (CSF), and the
structure of the brain ependymal layer – features that are critical for the efficient ventricular transport of
the CSF, and the structure of the aquaporin 4 (AQP4) channels, which serve as the key components of
the glymphatic system of transport.
Our proposal is in full alignment with the original R01 grant from the NIA “Glymphatic and CSF systems
in aging and Alzheimer’s disease”, which focuses on the mechanisms of the brain tissue homeostasis
and clearance in Alzheimer's. We now propose using our new techniques and findings on the ventricular
and glymphatic transport to determine the changes accompany aging and progression of the
Alzheimer's disease in a mouse model and to use this project as a platform for helping and directing
Kennelia Mellanson in developing her career as a researcher and a scholar. We present a detailed
plan for Kennelia’s professional development, including a detailed plan and timeline for mentorship,
manuscript and grant writing, didactic activities, improving the presentation skills, participation in
meetings and courses, and networking. Furthermore, we present a research plan for studying the key
components of the transport systems that may be compromised by aging and by Alzheimer's disease.
摘要
项目成果
期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Spatiotemporal 3D image registration for mesoscale studies of brain development.
时空3D图像登记,用于脑发育中尺度研究。
- DOI:10.1038/s41598-022-06871-8
- 发表时间:2022-03-07
- 期刊:
- 影响因子:4.6
- 作者:Shuvaev S;Lazutkin A;Kiryanov R;Anokhin K;Enikolopov G;Koulakov AA
- 通讯作者:Koulakov AA
The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum.
- DOI:10.1007/s00418-021-02048-y
- 发表时间:2022-02
- 期刊:
- 影响因子:2.3
- 作者:Maltsev, Dmitry I.;Mellanson, Kennelia A.;Belousov, Vsevolod V.;Enikolopov, Grigori N.;Podgorny, Oleg V.
- 通讯作者:Podgorny, Oleg V.
Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain.
- DOI:10.1152/physiol.00015.2022
- 发表时间:2022-11-01
- 期刊:
- 影响因子:0
- 作者:Zhao, Lucy;Tannenbaum, Allen;Benveniste, Helene
- 通讯作者:Benveniste, Helene
Age-related decline in cognitive flexibility is associated with the levels of hippocampal neurogenesis.
- DOI:10.3389/fnins.2023.1232670
- 发表时间:2023
- 期刊:
- 影响因子:4.3
- 作者:Amelchenko, Evgeny M.;Bezriadnov, Dmitri V.;Chekhov, Olga A.;Anokhin, Konstantin V.;Lazutkin, Alexander A.;Enikolopov, Grigori
- 通讯作者:Enikolopov, Grigori
NTnC-like genetically encoded calcium indicator with a positive and enhanced response and fast kinetics.
- DOI:10.1038/s41598-018-33613-6
- 发表时间:2018-10-15
- 期刊:
- 影响因子:4.6
- 作者:Barykina NV;Doronin DA;Subach OM;Sotskov VP;Plusnin VV;Ivleva OA;Gruzdeva AM;Kunitsyna TA;Ivashkina OI;Lazutkin AA;Malyshev AY;Smirnov IV;Varizhuk AM;Pozmogova GE;Piatkevich KD;Anokhin KV;Enikolopov G;Subach FV
- 通讯作者:Subach FV
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{{ truncateString('Helene D Benveniste', 18)}}的其他基金
Chronic Alcohol, Dementia, and CNS Fluid Homeostasis
慢性酒精、痴呆和中枢神经系统液体稳态
- 批准号:
10467520 - 财政年份:2022
- 资助金额:
$ 5.71万 - 项目类别:
Chronic Alcohol, Dementia, and CNS Fluid Homeostasis
慢性酒精、痴呆和中枢神经系统液体稳态
- 批准号:
10706469 - 财政年份:2022
- 资助金额:
$ 5.71万 - 项目类别:
Novel Knock in Mutation Rat Model for CARASIL
CARASIL 突变大鼠模型的新颖敲击
- 批准号:
10518554 - 财政年份:2022
- 资助金额:
$ 5.71万 - 项目类别:
Lymphatics-Glymphatics in CNS Fluid Homeostasis
CNS 液体稳态中的淋巴管-类淋巴管
- 批准号:
10371201 - 财政年份:2021
- 资助金额:
$ 5.71万 - 项目类别:
Robust workflow software for MRI tracking of glymphatic-lymphatic coupling
用于 MRI 跟踪类淋巴耦合的强大工作流程软件
- 批准号:
10609195 - 财政年份:2021
- 资助金额:
$ 5.71万 - 项目类别:
Lymphatics-Glymphatics in CNS Fluid Homeostasis
CNS 液体稳态中的淋巴管-类淋巴管
- 批准号:
10212759 - 财政年份:2021
- 资助金额:
$ 5.71万 - 项目类别:
Lymphatics-Glymphatics in CNS Fluid Homeostasis
CNS 液体稳态中的淋巴管-类淋巴管
- 批准号:
10595682 - 财政年份:2021
- 资助金额:
$ 5.71万 - 项目类别:
Nitric oxide-mediated changes in glymphatic and CSF systems in aging and Alzheimer's disease
一氧化氮介导的类淋巴和脑脊液系统在衰老和阿尔茨海默病中的变化
- 批准号:
10177549 - 财政年份:2017
- 资助金额:
$ 5.71万 - 项目类别:
Characterizing the glymphatic peri-vascular connectome and its disruption in AD
AD 中类淋巴血管周围连接组的特征及其破坏
- 批准号:
9452462 - 财政年份:2017
- 资助金额:
$ 5.71万 - 项目类别:
Characterizing the glymphatic peri-vascular connectome and its disruption in AD
AD 中类淋巴血管周围连接组的特征及其破坏
- 批准号:
9193854 - 财政年份:2016
- 资助金额:
$ 5.71万 - 项目类别:
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