Cooperative Human Tissue Network (CHTN)

项目概要/摘要 人体组织合作网络（CHTN）的建立是为了提供科学的 拥有用于癌症研究的高质量人体组织生物样本的社区。 CHTN 允许调查人员 获取进行前沿研究（包括基础和早期转化）所需的生物样本 癌症研究和检测开发。 作为 CHTN 的六个部门之一，CHTN 儿科部门 (pCHTN) 将接收、处理和分发 从儿童、青少年和年轻人身上收集的与科学相关的生物样本。这些 生物样本可包括恶性的、良性的、患病的和未受累的生物样本。 pCHTN 旨在 直接促进和支持慢性病诊断和治疗的前沿研究 癌症通过追求以下具体目标： 1. 除了全国儿童肿瘤中心之外，还利用与儿童肿瘤中心的关系 医院，从各种癌症中获取各种注释良好的生物样本，包括 来自罕见肿瘤类型和非癌性疾病的生物样本。 2. 通过向经批准的研究人员分发高质量的生物样本来支持前沿研究。 3. 最大限度地利用有限的生物样本资源并通过执行额外的操作来提供规模经济 生物样本的处理（例如核酸提取、组织微阵列、染色数字图像） 组织载玻片等） 4. 维持可靠、稳健的质量管理计划，监控生物样本的各个方面 收集、处理、储存和分发，以不断评估和改进我们的 运营能力，评估最佳实践，确保调查员满意度，并保护隐私和 对获取生物样本和数据的个人保密。 5. 通过跨网络互动的参与和协作，积极为CHTN做出贡献， 特别是在满足高度定制或非标准请求、参与协作网络方面 活动，并协调或制定新的战略，以确保 CHTN 始终响应 调查人员的需求。

PROJECT SUMMARY / ABSTRACT The Cooperative Human Tissue Network (CHTN) was established as a mechanism to provide the scientific community with high quality human tissue biospecimens for cancer research. The CHTN allows investigators to access the biospecimens they need to perform cutting-edge research, including basic and early translational cancer research, and assay development. As one of six CHTN Divisions, the Pediatric Division of the CHTN (pCHTN) will receive, process, and distribute scientifically-relevant biospecimens collected from children, adolescents, and young adults. These biospecimens can include malignant, benign, diseased, and uninvolved biospecimens. The pCHTN seeks to directly promote and support cutting-edge research in the diagnosis and treatment of chronic disease and cancer by pursuing the following specific aims: 1. To leverage the relationship with the Children’s Oncology Group, in addition to Nationwide Children’s Hospital, to procure a wide range of well-annotated biospecimens from a variety of cancers, including biospecimens from rare tumor types, and non-cancerous conditions. 2. To support cutting-edge research by distributing high-quality biospecimens to approved investigators. 3. To maximize limited biospecimen resources and provide economies of scale by performing additional processing of biospecimens (e.g. nucleic acid extraction, tissue microarrays, digital images of stained tissue slides, etc.) 4. To maintain a reliable and robust Quality Management Program that monitors all aspects of biospecimen collection, processing, storage, and distribution in an effort to constantly evaluate and improve our operational capabilities, assess best practices, ensure investigator satisfaction, and protect the privacy and confidentiality of those individuals from whom the biospecimens and data were obtained. 5. To actively contribute to the CHTN by participation and collaboration in trans-Network interactions, particularly in fulfilling highly-customized or non-standard requests, participating in collaborative Network activities, and coordinating or developing new strategies to ensure that the CHTN remains responsive to investigators’ needs.