SWOG Biospecimen Bank to Support NCI NCTN

SWOG 生物样本库将支持 NCI NCTN

• 批准号: 10249355
• 负责人: NILSA DEL CARMEN RAMIREZ MILAN
• 金额: $ 335.98万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-23 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10249355
• 关键词: Address; Adult; Biological Specimen Banks; Breast; Cancer Patient; Clinical; Clinical Data; Clinical Medicine; Clinical Research; Clinical Treatment; Clinical Trials; Clinical Trials Information for Patients; Clinical trial protocol document; Collection; Colon; Component of the National Cancer Institute; Coupled; Data; Data Reporting; Diagnostic; Disease; Enrollment; Ensure; Epidemiology; Goals; Guidelines; Health; Human; Immunologic Monitoring; Laboratories; Link; Lung; Lymphoma; Malignant Neoplasms; Marketing; Molecular Biology; Molecular Profiling; Multiple Myeloma; National Cancer Institute; National Clinical Trials Network; Operative Surgical Procedures; Participant; Pathologic; Patients; Pediatric Hospitals; Policies; Procedures; Process; Prostate; Protocols documentation; Quality Control; Reporting; Research; Research Institute; Research Personnel; Residual state; Resources; Sampling; Services; Site; Southwest Oncology Group; System; Technology; Therapeutic; Translational Research; Treatment Protocols; Work; anticancer research; base; biobank; cancer clinical trial; cancer prevention; cancer type; data management; data sharing; design; experience; follow-up; improved; improved outcome; innovative technologies; laboratory equipment; leukemia; melanoma; operation; programs; targeted treatment; therapy outcome; translational medicine; tumor

Project Summary SWOG is an adult clinical trials cancer group within the National Clinical Trials Network (NCTN) of the National Cancer Institute (NCI). SWOG clinical trials include a range of cancer types (e.g., breast, lung, colon, prostate, leukemia, melanoma, lymphoma, and multiple myeloma). The SWOG Biospecimen Bank (Biobank), located in the Biopathology Center (part of the Abigail Wexner Research Institute of Nationwide Children's Hospital), was designed to procure, process, bank, and distribute biospecimens collected as a major component of NCI- sponsored clinical trials. These biospecimens are linked to demographic information, surgical and pathological reports, and treatment and follow-up data of study participants enrolled on SWOG protocols. Upon review and approval, biospecimens are prioritized for distribution to the specific SWOG investigators defined in the clinical trial protocols. After the needs of the planned research have been addressed, residual (legacy) banked biospecimens can be distributed to other investigators within and outside SWOG via the NCTN Navigator. The SWOG Group and Biobank Concierges can also facilitate access to SWOG legacy biospecimens that are not currently uploaded in Navigator. This process has been designed to mirror the process for legacy biospecimens on the Navigator system and includes a feasibility assessment by the SWOG Biobank and the SWOG Statistical and Data Management Center prior to proposal submission. The Biobank is a functioning and viable part of SWOG's clinical and translational medicine program, and focuses on the integration of diagnostic, therapeutic, laboratory, and clinical data to answer questions in clinical and translational research. The SWOG Biobank works under the hypothesis that banking of high quality, clinically-annotated and cancer- related human biospecimens, linked to molecular signatures/markers, will significantly facilitate and further advance clinical cancer research. To support this effort, the SWOG Biobank manages these biospecimens under strict guidelines and standard operating procedures based on current Best Practices for biorepositories and the latest laboratory technologies. The Biobank's experience, coupled with a firm commitment to quality and integrity operations, makes it uniquely able to provide an accurate and effective resource of tumor and normal samples with associated clinical, epidemiologic, and protected health information. The SWOG Biobank aims to harmonize and expand general banking practices and innovative technologies, which will continue to facilitate molecular biology research and increase investigator participation in clinical research trials via the NCI-sponsored Group Banking Committee (GBC). The SWOG Biobank also plans to support the processing, banking, and distribution of biospecimens to the Cancer Immune Monitoring and Analysis Centers (CIMACs).

项目摘要 SWOG是美国国家临床试验网络（NCTN）内的一个成人临床试验癌症小组。 癌症研究所（NCI）。SWOG临床试验包括一系列癌症类型（例如，乳腺，肺，结肠，前列腺 白血病、黑素瘤、淋巴瘤和多发性骨髓瘤）。SWOG生物样本库（Biobank），位于 生物病理学中心（全国儿童医院阿比盖尔韦克斯纳研究所的一部分），是 旨在采购、处理、储存和分发作为NCI主要组成部分收集的生物标本- 赞助的临床试验。这些生物样本与人口统计学信息、手术和病理信息相关联， 报告，以及根据SWOG方案登记的研究参与者的治疗和随访数据。审阅和 批准后，生物标本优先分发给临床试验中定义的特定SWOG研究者 试验方案。在计划研究的需求得到满足后， 生物样本可以通过NCTN Navigator分发给SWOG内外的其他研究者。的 SWOG Group和Biobank Concierges还可以方便地访问未被保存的SWOG遗留生物标本。 目前已在导航器中加载。此流程旨在反映传统流程 导航系统上的生物标本，包括SWOG生物库和 SWOG统计和数据管理中心在提交提案之前。生物库是一个功能正常的 和可行的一部分，SWOG的临床和转化医学计划，并侧重于整合 诊断、治疗、实验室和临床数据，以回答临床和转化研究中的问题。 SWOG生物库的工作假设是，高质量的，临床注释和癌症- 与分子特征/标记相关的人类生物标本，将大大促进和进一步 推进临床癌症研究。为了支持这项工作，SWOG生物库管理这些生物标本， 在严格的指导方针和标准操作程序下，根据当前生物储存库的最佳实践 最新的实验室技术。生物库的经验，加上对质量的坚定承诺， 和完整的操作，使其能够独特地提供准确和有效的肿瘤资源， 正常样本与相关的临床，流行病学和受保护的健康信息。SWOG生物银行 旨在协调和扩大一般银行业务和创新技术，这将继续 促进分子生物学研究，并通过 NCI赞助的集团银行委员会（GBC）。SWOG生物银行也计划支持处理， 将生物样本储存和分发到癌症免疫监测和分析中心（CIMAC）。