Support for Human Specimen Banking in NCI-Sponsored Clinical Trials-(CGB)

对 NCI 资助的临床试验中的人体样本库的支持 - (CGB)

• 批准号: 8516416
• 负责人: NILSA DEL CARMEN RAMIREZ MILAN
• 金额: $ 168.49万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-03 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8516416
• 关键词: Acute Lymphocytic Leukemia; Acute Myelocytic Leukemia; Adolescent; Basic Science; Biological; Cancer Patient; Cancer Therapy Evaluation Program; Child; Childhood; Childhood Cancer Survivor Study; Children' s Oncology Group; Client; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Collection; Conduct Clinical Trials; Cooperative Human Tissue Network; Data; Emerging Technologies; Enrollment; Ensure; Fred Hutchinson Cancer Research Center; Funding; Grant; Gynecologic Oncology Group; Housing; Human; Laboratories; Link; Malignant Childhood Neoplasm; Malignant Neoplasms; Molecular; Molecular Profiling; Neuroblastoma; Ohio; Patients; Pediatric Hospitals; Play; Procedures; Protocols documentation; Quality Control; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Role; Rosa; Solid; Specimen; Survival Rate; Testing; Therapeutic; Tissue Banking; Tissue Banks; Translational Research; Treatment outcome; United States; Washington; Work; biobank; improved; mortality; patient population; population based; racial and ethnic; research clinical testing; research study; success; treatment trial

DESCRIPTION (provided by applicant): Over 90% of United States and Canadian children and adolescents with cancer are enrolled in Children's Oncology Group (COG) clinical trials with no racial, ethnic or geographic bias to registration, allowing for near- population-based clinical, translational and basic research. Clinical trials conducted by COG and its antecedent organizations have played a major role in these advances and will continue to drive the improvements projected to come in the next decade. The biospecimens collected during these clinical treatment trials are crucial to their success. These biospecimens are sent to centralized laboratories for clinical testing and banking for future research use. The Biopathology Center (BPC) is part of the Research Institute at Nationwide Children's Hospital in Columbus, Ohio and houses the COG Solid Tissue Bank as well as the COG ALL Molecular Reference Laboratory and Bank. The COG AML Reference Laboratory and Bank is located at the Fred Hutchinson Cancer Research Center Seattle, Washington. Currently, the BPC is federally funded to serve several clients (including the Pediatric Division of the Cooperative Human Tissue Network [pCHTN], and the biobanking efforts of the Gynecologic Oncology Group [GOG], the Childhood Cancer Survivor Study [CCSS], and the Cancer Therapy Evaluation Program [CTEP]). To accomplish this, the banks continue to work with the aims of the original grant submission in 2004. 1. Establish collection, storage and quality control procedures for tissue banking in pediatric cancer patients that are near-population-based. 2. Ensure proper storage and quality control procedures for pediatric tissue bank biospecimens that promote outstanding retrospective translational research. 3. Ensure proper administration of tissue bank resources to facilitate investigator access to biospecimens. 4. Promote linkage of tissue bank resources to existing demographic, clinical, and biological, treatment and outcome data. 5. Optimize utilization of finite tissue bank resources utilizing emerging technologies.

描述（由申请人提供）：超过90%的美国和加拿大儿童和青少年癌症患者参加了儿童肿瘤组（COG）临床试验，对注册没有种族，民族或地理偏见，允许近人群的临床，转化和基础研究。由COG及其前身组织进行的临床试验在这些进步中发挥了重要作用，并将继续推动预计在未来十年内实现的改进。在这些临床治疗试验期间收集的生物标本对其成功至关重要。这些生物样本被送往中心实验室进行临床检测和储存，以供未来研究使用。生物病理学中心（BPC）是位于俄亥俄州哥伦布的全国儿童医院研究所的一部分，设有COG固体组织库以及COG ALL分子参考实验室和库。COG AML参考实验室和库位于华盛顿西雅图的弗雷德哈钦森癌症研究中心。目前，BPC由联邦政府资助，为几个客户提供服务（包括合作人体组织网络[pCHTN]的儿科部门，妇科肿瘤组[GOG]的生物库工作，儿童癌症幸存者研究[CCSS]和癌症治疗评估计划[CTEP]）。为了实现这一目标，银行继续努力实现2004年最初赠款申请的目标。1.建立儿科癌症患者组织库的收集、储存和质量控制程序，以接近人群。2.确保儿科组织库生物标本的适当储存和质量控制程序，以促进杰出的回顾性转化研究。3.确保组织库资源的适当管理，以便于研究者访问生物标本。4.促进组织库资源与现有人口统计学、临床和生物学、治疗和结果数据的联系。5.利用新兴技术优化有限组织库资源的利用。