Support for Human Specimen Banking in NCI-Sponsored Clinical Trials-(CGB)

对 NCI 资助的临床试验中的人体样本库的支持 - (CGB)

• 批准号: 7991591
• 负责人: NILSA DEL CARMEN RAMIREZ MILAN
• 金额: $ 81.71万
• 依托单位: NATIONAL CHILDHOOD CANCER FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-03 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7991591
• 关键词: Acute Lymphocytic Leukemia; Acute Myelocytic Leukemia; Adolescent; Basic Science; Biological; Cancer Patient; Cancer Therapy Evaluation Program; Child; Childhood; Childhood Cancer Survivor Study; Children' s Oncology Group; Client; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Collection; Conduct Clinical Trials; Cooperative Human Tissue Network; Data; Emerging Technologies; Enrollment; Ensure; Fred Hutchinson Cancer Research Center; Funding; Grant; Gynecologic Oncology Group; Housing; Human; Laboratories; Malignant Childhood Neoplasm; Malignant Neoplasms; Molecular; Neuroblastoma; Ohio; Patients; Pediatric Hospitals; Play; Procedures; Quality Control; Research; Research Institute; Research Personnel; Resources; Role; Rosa; Solid; Specimen; Survival Rate; Tissue Banking; Tissue Banks; Translational Research; Treatment outcome; United States; Washington; Work; biobank; improved; mortality; population based; racial and ethnic; research clinical testing; success; treatment trial

DESCRIPTION (provided by applicant): Over 90% of United States and Canadian children and adolescents with cancer are enrolled in Children's Oncology Group (COG) clinical trials with no racial, ethnic or geographic bias to registration, allowing for near- population-based clinical, translational and basic research. Clinical trials conducted by COG and its antecedent organizations have played a major role in these advances and will continue to drive the improvements projected to come in the next decade. The biospecimens collected during these clinical treatment trials are crucial to their success. These biospecimens are sent to centralized laboratories for clinical testing and banking for future research use. The Biopathology Center (BPC) is part of the Research Institute at Nationwide Children's Hospital in Columbus, Ohio and houses the COG Solid Tissue Bank as well as the COG ALL Molecular Reference Laboratory and Bank. The COG AML Reference Laboratory and Bank is located at the Fred Hutchinson Cancer Research Center Seattle, Washington. Currently, the BPC is federally funded to serve several clients (including the Pediatric Division of the Cooperative Human Tissue Network [pCHTN], and the biobanking efforts of the Gynecologic Oncology Group [GOG], the Childhood Cancer Survivor Study [CCSS], and the Cancer Therapy Evaluation Program [CTEP]). To accomplish this, the banks continue to work with the aims of the original grant submission in 2004. 1. Establish collection, storage and quality control procedures for tissue banking in pediatric cancer patients that are near-population-based. 2. Ensure proper storage and quality control procedures for pediatric tissue bank biospecimens that promote outstanding retrospective translational research. 3. Ensure proper administration of tissue bank resources to facilitate investigator access to biospecimens. 4. Promote linkage of tissue bank resources to existing demographic, clinical, and biological, treatment and outcome data. 5. Optimize utilization of finite tissue bank resources utilizing emerging technologies. RELEVANCE: Today, over 80% of children with cancer are expected to be cured, with an approximately 50% decrease in mortality rate between 1975 and 2006. Five-year survival rates for acute myeloid leukemia (AML) and neuroblastoma have seen vast improvements. AML survival increased from under 50% to 60% and neuroblastoma survival rose from 65% to 75%. The higher survival rates of patients with acute lymphoblastic leukemia (ALL) improved from 86.8% to 89.0%. COG research has played a major role in improvements.

描述（由申请人提供）：超过 90% 的美国和加拿大患有癌症的儿童和青少年都参加了儿童肿瘤学组 (COG) 临床试验，注册时没有种族、民族或地理偏见，允许进行近人群临床、转化和基础研究。 COG 及其前身组织进行的临床试验在这些进步中发挥了重要作用，并将继续推动未来十年预计的改进。在这些临床治疗试验期间收集的生物样本对于其成功至关重要。这些生物样本被送往集中实验室进行临床测试并储存以供将来的研究使用。生物病理学中心 (BPC) 是俄亥俄州哥伦布市全国儿童医院研究所的一部分，拥有 COG 固体组织库以及 COG ALL 分子参考实验室和库。 COG AML 参考实验室和银行位于华盛顿州西雅图 Fred Hutchinson 癌症研究中心。目前，BPC 由联邦政府资助为多个客户提供服务（包括人体组织合作网络 [pCHTN] 的儿科部门、妇科肿瘤小组 [GOG] 的生物样本库工作、儿童癌症幸存者研究 [CCSS] 和癌症治疗评估计划 [CTEP]）。为了实现这一目标，银行继续努力实现 2004 年最初提交的赠款目标。 1. 为接近人群的儿科癌症患者的组织库建立收集、储存和质量控制程序。 2. 确保儿科组织库生物样本的适当储存和质量控制程序，以促进杰出的回顾性转化研究。 3. 确保组织库资源的适当管理，以方便研究者获取生物样本。 4. 促进组织库资源与现有人口、临床、生物、治疗和结果数据的联系。 5. 利用新兴技术优化有限组织库资源的利用。 相关性：如今，超过 80% 的癌症儿童有望得到治愈，1975 年至 2006 年间死亡率下降了约 50%。急性髓系白血病 (AML) 和神经母细胞瘤的五年生存率已大幅提高。 AML 存活率从 50% 以下提高到 60%，神经母细胞瘤存活率从 65% 提高到 75%。急性淋巴细胞白血病（ALL）患者的生存率从 86.8% 提高到 89.0%。 COG 研究在改进方面发挥了重要作用。