Cooperative Human Tissue Network (CHTN)

项目总结/摘要 合作人类组织网络（CHTN）是作为一个机制，提供科学的 为癌症研究提供高质量的人体组织生物标本。CHTN允许调查人员 获取他们进行尖端研究所需的生物标本，包括基础和早期转化研究， 癌症研究和分析开发。 作为六个CHTN部门之一，CHTN儿科部门（pCHTN）将接收，处理和分发 从儿童、青少年和年轻人中收集的科学相关生物标本。这些 生物样本可以包括恶性的、良性的、患病的和未涉及的生物样本。pCHTN旨在 直接促进和支持慢性病诊断和治疗方面的前沿研究， 通过追求以下具体目标来治疗癌症： 1.为了利用与儿童肿瘤学小组的关系，除了全国儿童 医院，从各种癌症中获得广泛的注释良好的生物标本，包括 来自罕见肿瘤类型和非癌性疾病的生物样本。 2.通过向批准的研究者分发高质量的生物标本来支持尖端研究。 3.为了最大限度地利用有限的生物标本资源，并通过执行额外的 生物样本的处理（例如核酸提取、组织微阵列、染色的数字图像） 组织载玻片等） 4.保持可靠和稳健的质量管理计划，以监测生物标本的各个方面 收集、处理、储存和分发，以不断评估和改进我们的 运营能力，评估最佳实践，确保调查者满意度，保护隐私， 生物标本和数据的获取者的保密性。 5.通过参与和合作跨网络互动，积极为CHTN做出贡献， 特别是在满足高度定制或非标准的要求，参与协作网络 活动，并协调或制定新的战略，以确保CHTN仍然响应 调查人员的需要。

PROJECT SUMMARY / ABSTRACT The Cooperative Human Tissue Network (CHTN) was established as a mechanism to provide the scientific community with high quality human tissue biospecimens for cancer research. The CHTN allows investigators to access the biospecimens they need to perform cutting-edge research, including basic and early translational cancer research, and assay development. As one of six CHTN Divisions, the Pediatric Division of the CHTN (pCHTN) will receive, process, and distribute scientifically-relevant biospecimens collected from children, adolescents, and young adults. These biospecimens can include malignant, benign, diseased, and uninvolved biospecimens. The pCHTN seeks to directly promote and support cutting-edge research in the diagnosis and treatment of chronic disease and cancer by pursuing the following specific aims: 1. To leverage the relationship with the Children’s Oncology Group, in addition to Nationwide Children’s Hospital, to procure a wide range of well-annotated biospecimens from a variety of cancers, including biospecimens from rare tumor types, and non-cancerous conditions. 2. To support cutting-edge research by distributing high-quality biospecimens to approved investigators. 3. To maximize limited biospecimen resources and provide economies of scale by performing additional processing of biospecimens (e.g. nucleic acid extraction, tissue microarrays, digital images of stained tissue slides, etc.) 4. To maintain a reliable and robust Quality Management Program that monitors all aspects of biospecimen collection, processing, storage, and distribution in an effort to constantly evaluate and improve our operational capabilities, assess best practices, ensure investigator satisfaction, and protect the privacy and confidentiality of those individuals from whom the biospecimens and data were obtained. 5. To actively contribute to the CHTN by participation and collaboration in trans-Network interactions, particularly in fulfilling highly-customized or non-standard requests, participating in collaborative Network activities, and coordinating or developing new strategies to ensure that the CHTN remains responsive to investigators’ needs.