Cooperative Human Tissue Network (CHTN)

项目摘要/摘要 合作的人类组织网络(CHTN)是为了提供科学的 为癌症研究提供高质量的人体组织生物标本的社区。CHTN允许调查人员 为了获得生物制品，他们需要进行尖端研究，包括基础和早期翻译 癌症研究和化验发展。 作为CHTN的六个部门之一，CHTN儿科(PCHTN)将接收、处理和分发 从儿童、青少年和青壮年收集的具有科学意义的生物标本。这些 生物标本可以包括恶性的、良性的、患病的和非受累的生物标本。PCHTN寻求 直接推动和支持慢性疾病诊断和治疗方面的前沿研究 通过追求以下具体目标来治疗癌症： 1.利用与儿童肿瘤学组织的关系，以及全国儿童肿瘤组织 医院，从各种癌症中采购各种注释良好的生物标本，包括 来自罕见肿瘤类型和非癌症条件的生物标本。 2.向经批准的研究人员分发高质量的生物标本，以支持尖端研究。 3.最大限度地利用有限的生物菌种资源，并通过执行更多的 生物标本的处理(例如，核酸提取、组织微阵列、染色的数字图像 组织载玻片等) 4.维持一个可靠和稳健的质量管理计划，以监测生物检疫的各个方面 收集、处理、存储和分发，以不断评估和改进我们的 运营能力，评估最佳实践，确保调查人员满意度，并保护隐私和 对从其获得生物标本和数据的个人的机密性。 5.通过参与和协作跨网络互动，积极为CHTN做出贡献， 特别是在满足高度定制或非标准请求方面，参与协作网络 活动，并协调或制定新的战略，以确保卫生与环境卫生网络继续对 调查人员的需求。

PROJECT SUMMARY / ABSTRACT The Cooperative Human Tissue Network (CHTN) was established as a mechanism to provide the scientific community with high quality human tissue biospecimens for cancer research. The CHTN allows investigators to access the biospecimens they need to perform cutting-edge research, including basic and early translational cancer research, and assay development. As one of six CHTN Divisions, the Pediatric Division of the CHTN (pCHTN) will receive, process, and distribute scientifically-relevant biospecimens collected from children, adolescents, and young adults. These biospecimens can include malignant, benign, diseased, and uninvolved biospecimens. The pCHTN seeks to directly promote and support cutting-edge research in the diagnosis and treatment of chronic disease and cancer by pursuing the following specific aims: 1. To leverage the relationship with the Children’s Oncology Group, in addition to Nationwide Children’s Hospital, to procure a wide range of well-annotated biospecimens from a variety of cancers, including biospecimens from rare tumor types, and non-cancerous conditions. 2. To support cutting-edge research by distributing high-quality biospecimens to approved investigators. 3. To maximize limited biospecimen resources and provide economies of scale by performing additional processing of biospecimens (e.g. nucleic acid extraction, tissue microarrays, digital images of stained tissue slides, etc.) 4. To maintain a reliable and robust Quality Management Program that monitors all aspects of biospecimen collection, processing, storage, and distribution in an effort to constantly evaluate and improve our operational capabilities, assess best practices, ensure investigator satisfaction, and protect the privacy and confidentiality of those individuals from whom the biospecimens and data were obtained. 5. To actively contribute to the CHTN by participation and collaboration in trans-Network interactions, particularly in fulfilling highly-customized or non-standard requests, participating in collaborative Network activities, and coordinating or developing new strategies to ensure that the CHTN remains responsive to investigators’ needs.