Core B- Biospecimen Core

核心B--Biospecimen核心：摘要/摘要： 这个LMS孢子的项目将使用平滑肌肉瘤(LMS)生物样本进行翻译研究。一把钥匙 这一核心的功能将是确保LMS诊断的准确性。为此，杰森·霍尼克博士，医学博士， 作为肉瘤病理学家的专家，将与Nilsa Ramirez医学博士共同指导Biospecimen Core，Nilsa Ramirez是 生物信息库和银行业务。Biosecimen核心的功能将包括病理学审查， 从参与LMS孢子临床研究的机构采购Biospecimen，基础和 专门处理、管理与生物检疫有关的数据，并将生物检疫和数据分配给 项目调查员。为该LMS孢子收集的生物检疫剂将优先分配给LMS 已确定项目的孢子调查员。在解决了计划研究的需求之后， 利用已建立的现有机制，可将储存的残留物分发给其他研究人员。 这个LMS孢子的行政核心/MPI。 Biospecimen核心将提供最新的基于生物库的技术创新和最佳实践， 导致业务能力的不断提高，调查人员获得生物武器，以及 对这些宝贵资源的管理。尼尔萨·拉米雷斯博士，他在管理方面有丰富的经验 负责生物样品质量控制、加工和储存的部门将监督生物样品核心的所有活动和 将就生物检疫最佳做法向项目负责人提供指导。霍尼克博士将监督 回顾病理和组织学评估，以确认所有LMS病例的诊断，并将作为仲裁者 在诊断不一致的情况下。 Biosecimen核心将与管理核心和项目领导密切合作，以确保 计划中的研究取得成功。这种LMS孢子的协作性对于研究这一现象是必要的 罕见恶性肿瘤的亚型，只有多机构合作才能促进获得足够的 生物质学家资源对取得进展至关重要。储存在生物谱系核心中的生物谱系将提供 对于LMS孢子团队以及未来的调查人员来说，这是一个必不可少的资源。

Core B – Biospecimen Core: Summary/Abstract: The projects of this LMS SPORE will use leiomyosarcoma (LMS) biospecimens for translational research. A key function of this Core will be ensuring the accuracy of diagnosis of LMS. To that end, Jason Hornick, MD, PhD, an expert sarcoma pathologist, will Co-Direct the Biospecimen Core along with Nilsa Ramirez, MD, an expert in biospecimen repositories and banking. The functions of the Biospecimen Core will include pathology review, biospecimen procurement from the institutions participating in the LMS SPORE clinical studies, basic and specialized processing, management of biospecimen-related data, and distribution of biospecimens and data to project investigators. Biospecimens collected for this LMS SPORE will be prioritized to distribute to the LMS SPORE investigators for the defined projects. After the needs of the planned research have been addressed, residual banked biospecimens can be distributed to other investigators using existing mechanisms established by the Administrative Core/MPI of this LMS SPORE. The Biospecimen Core will provide the latest biorepository-based technological innovations and best practices, resulting in constant improvements in operational capabilities, investigator access to biospecimens, and the stewardship of these precious resources. Dr. Nilsa Ramirez, who has extensive experience in the management of biospecimen quality control, processing, and banking, will oversee all activities of the Biospecimen Core and will provide guidance to the Project leaders regarding biospecimen best practices. Dr. Hornick will oversee the review of pathology and histology assessments to confirm diagnosis of all cases of LMS and will be the arbiter in case of discrepancy in the diagnosis. The Biospecimen Core will work closely with the Administrative Core and the project leadership to ensure the success of the planned research. The collaborative nature of this LMS SPORE is necessary for the study of this subtype of rare malignancies, where only multi-institutional cooperation can facilitate the acquisition of sufficient biospecimen resources vital to make progress. The biospecimens banked in the Biospecimen Core will provide an essential resource for the LMS SPORE team as well as future investigators.