Core B- Biospecimen Core

核心 B- 生物样本核心

• 批准号: 10493632
• 负责人: NILSA DEL CARMEN RAMIREZ MILAN
• 金额: $ 17.39万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493632
• 关键词: Address; Adult; Biological Assay; Biological Specimen Banks; Blood; Cancer Biology; Cells; Child; Clinical Research; Collection; Data; Databases; Dermis; Diagnosis; Doctor of Philosophy; Enrollment; Ensure; Future; Gastrointestinal tract structure; Genetic; Genomics; Guidelines; Heart; Histology; Hospitals; Human; Immunohistochemistry; Institution; Leadership; Limb structure; Malignant Neoplasms; Nature; Neoplasm Metastasis; Nucleic Acids; Organ; Pathologist; Pathology; Patients; Pediatric Hospitals; Physician Executives; Population; Procedures; Prognosis; Protocols documentation; Quality Control; Research; Research Institute; Research Personnel; Residual state; Resolution; Resources; Retroperitoneal Space; Sampling; Services; Slide; Smooth Muscle; Soft tissue sarcoma; Stains; Standardization; Surgical Pathology; Tissue Microarray; Tissues; Translational Research; Uterus; Veins; Woman; Work; accurate diagnosis; base; biobank; bone; diagnostic accuracy; digital imaging; experience; imaging system; improved; innovation; leiomyosarcoma; medical schools; novel strategies; professor; rare cancer; sarcoma; success; technological innovation; translational goal; tumor

Core B – Biospecimen Core: Summary/Abstract: The projects of this LMS SPORE will use leiomyosarcoma (LMS) biospecimens for translational research. A key function of this Core will be ensuring the accuracy of diagnosis of LMS. To that end, Jason Hornick, MD, PhD, an expert sarcoma pathologist, will Co-Direct the Biospecimen Core along with Nilsa Ramirez, MD, an expert in biospecimen repositories and banking. The functions of the Biospecimen Core will include pathology review, biospecimen procurement from the institutions participating in the LMS SPORE clinical studies, basic and specialized processing, management of biospecimen-related data, and distribution of biospecimens and data to project investigators. Biospecimens collected for this LMS SPORE will be prioritized to distribute to the LMS SPORE investigators for the defined projects. After the needs of the planned research have been addressed, residual banked biospecimens can be distributed to other investigators using existing mechanisms established by the Administrative Core/MPI of this LMS SPORE. The Biospecimen Core will provide the latest biorepository-based technological innovations and best practices, resulting in constant improvements in operational capabilities, investigator access to biospecimens, and the stewardship of these precious resources. Dr. Nilsa Ramirez, who has extensive experience in the management of biospecimen quality control, processing, and banking, will oversee all activities of the Biospecimen Core and will provide guidance to the Project leaders regarding biospecimen best practices. Dr. Hornick will oversee the review of pathology and histology assessments to confirm diagnosis of all cases of LMS and will be the arbiter in case of discrepancy in the diagnosis. The Biospecimen Core will work closely with the Administrative Core and the project leadership to ensure the success of the planned research. The collaborative nature of this LMS SPORE is necessary for the study of this subtype of rare malignancies, where only multi-institutional cooperation can facilitate the acquisition of sufficient biospecimen resources vital to make progress. The biospecimens banked in the Biospecimen Core will provide an essential resource for the LMS SPORE team as well as future investigators.

核心B -生物标本核心：总结/摘要： 这个LMS SPORE的项目将使用平滑肌肉瘤（LMS）生物标本进行转化研究。一个关键 该核心的功能将确保LMS诊断的准确性。为此，Jason Hornick，医学博士， 一位专家肉瘤病理学家，将共同指导生物标本核心沿着与尼尔萨拉米雷斯，医学博士，专家在 生物标本库和银行。生物样本核心的功能将包括病理学审查， 从参与LMS SPORE临床研究的机构采购生物标本，基础和 专门处理、管理生物样本相关数据，并将生物样本和数据分发给 项目调查员。为此LMS SPORE采集的生物标本将优先分发给LMS SPORE调查员对已定义的项目进行调查。在计划研究的需求得到解决后， 剩余的库存生物样本可以使用已建立的现有机制分发给其他研究者 由该LMS SPORE的管理核心/MPI执行。 生物样本核心将提供最新的生物实验室技术创新和最佳实践， 从而不断提高业务能力，调查人员获得生物标本， 保护这些宝贵的资源。Nilsa Ramirez博士在管理方面拥有丰富的经验， 生物样本质量控制、处理和库管理，将监督生物样本核心的所有活动， 将为项目负责人提供有关生物标本最佳实践的指导。霍尼克医生会监督 审查病理学和组织学评估，以确认所有LMS病例的诊断，并将作为仲裁者 以防诊断不一致 生物样本核心将与行政核心和项目领导密切合作，以确保 计划研究的成功。这个LMS孢子的协作性质是必要的研究， 罕见恶性肿瘤的亚型，只有多机构合作才能促进获得足够的 生物标本资源对取得进展至关重要。生物样本库中的生物样本将提供 LMS SPORE团队以及未来研究人员的重要资源。