CRCNS: MOVE!-MOdeling of fast Movement for Enhancement via neuroprosthetics

跟踪快速不可预测的动作是一项宝贵的技能，适用于许多情况。在动物身上 在《王国》中，上下文包括捕食者在高处追逐其正在奔跑和躲避的猎物的行为 速度，就像猎豹追赶瞪羚。感应器运动控制系统(Scs)负责这样做。 动作及其性能显然取决于神经元的计算能力，大脑和大脑之间的延迟 肌肉，以及所涉及的肌肉的动力学。尽管这些明显的因素限制了 动物可以跟踪运动物体，SCS的跟踪性能及其对神经的依赖 计算、延迟和肌肉动力学还没有被明确量化。在这个项目中，我们将构建 基于使用反馈控制原理开发的新理论和适当简化的模型 SCS来确定神经计算、延迟和肌肉在产生快速动作时是如何相互作用的。 因此，如果一个组件受损，我们可以利用其他组件进行恢复 辅助性神经假体装置的运动表现。 该计划的目标是首先对限制快速运动的主要因素(大脑和身体)进行参数化 并推导出这些参数必须如何相互作用以实现对SCS中的快速移动的跟踪。然后, 参数化和量化的相互作用将在受试者身上进行实验测试，通过 操纵(I)神经计算能力，(Ii)传输延迟，和(Iii)肌肉动力学。如果 实验和理论之间出现了差异，将对SCS模型和理论进行修改以解释 观测数据。最后，给出了实现快速运动跟踪所需的交互作用理论模型 将被利用来应用补偿，以通过“提升”其他参数来解释某些参数的退化。 更具体地说，我们将为神经受损的受试者设计辅助神经假体设备 房地产恢复快速走势表现。例如，如果初级运动皮质受损 由于疾病或损伤，我们可以通过增加必要的补偿来操纵肌肉动力学 恢复运动性能的力量，更重要的是恢复快速和敏捷的动作。只有一个人 应赔付将由我们的SCS模型和理论来通知。

Tracking fast unpredictable movements is a valuable skill, applicable in many situations. In the animal kingdom, the context includes the action of a predator chasing its prey that is running and dodging at high speeds, like a cheetah chasing a gazelle. The sensorimotor control system (SCS) is responsible for such actions and its performance clearly depends on the computing power of neurons, delays between brain and muscles, and the dynamics of muscles involved. Despite these obvious factors that set the limits on how fast an animal can track a moving object, tracking performance of the SCS and its dependence on neural computing, delays, and muscle dynamics have not been explicitly quantified. In this program, we will build upon new theory developed using feedback control principles and an appropriately simplified model of the SCS to identify how neural computing, delays, and muscles interact during the generation of fast movements. Therefore if one component is compromised, we can take advantage of the other components to restore motor performance with assistive neuroprosthetic devices. The program objectives are to first parameterize the major factors (brain and body) limiting fast movements and to derive how these parameters must interact to achieve tracking of fast movements in the SCS. Then, the parameterization and quantified interactions will be tested experimentally in subjects through manipulation of (i) neural computing power, (ii) transmission delays, and (iii) muscle dynamics. If discrepancies emerge between experiments and theory, the SCS model and theory will be modified to explain observation data. Finally, the theoretical model of interactions required to achieve tracking of fast movements will be exploited to apply compensation to account for degradation of some parameters by "boosting" others. More specifically, we will design assistive neuroprosthetic devices for subjects having compromised neural real estate to restore performance of fast movements. For example, if primary motor cortex is compromised due to disease or damage, we can manipulate muscle dynamics by adding the necessary compensatory forces to restore motor performance, and more importantly restore fast and agile movements. Just how one should compensate will be informed by our SCS model and theory.