Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate (IPP) in rats (after perinatal exposure)

该项目的目标是为国家毒理学规划司（DNTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。本项目涉及通过给药饲料暴露在大鼠体内的异丙基苯酚磷酸（IPP）的毒性研究；暴露发生在妊娠期和哺乳期以及断奶后三个月。IPP是一种芳香型有机磷酸盐阻燃剂。由于这类阻燃剂正在取代其他类别的阻燃剂，预计会增加使用。一般人群通过其在消费品和环境中的存在而暴露于IPP。该项目的数据将用于制定关于IPP潜在毒性的合理科学结论，并最终支持DNTP的使命和目标以及其他联邦机构的风险评估活动。

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of isopropylated phenol phosphate (IPP) in rats, following exposure via dosed feed; exposures occur during gestation and lactation and for three months after weaning. IPP is an aromatic organo phosphate flame retardant. Increased use is anticipated as this class is replacing other classes of flame retardants. Exposure to IPP occurs in the general population via its presence in consumer products and in the environment. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of IPP and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. Keywords: toxicity, isopropylated phenol phosphate, dosed feed, flame retardant