Conduct of studies to evaluate the subchronic and developmental neurotoxicity of isopropylated phenol phosphate (IPP) and triphenyl phosphate (TPHP)in rats (after perinatal exposure)

进行研究以评估异丙基磷酸苯酚 (IPP) 和磷酸三苯酯 (TPHP) 对大鼠的亚慢性和发育神经毒性（围产期暴露后）

• 批准号: 10788075
• 负责人: Barney Sparrow
• 金额: $ 198.5万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2023-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788075
• 关键词: Adverse effects; Chemicals; Data; Development; Dose; Environment; Environmental Exposure; Evaluation; Exposure to; Flame Retardants; General Population; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Lactation; Mission; Perinatal Exposure; Phenols; Pregnancy; Rattus; Risk Assessment; Toxic effect; Toxicity Tests; Toxicology; Weaning; consumer product; design; developmental neurotoxicity; developmental toxicity; disorder prevention; inorganic phosphate; public health research; sound

The goal of this project is to provide support of the Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of isopropylated phenol phosphate (IPP) and triphenyl phosphate (TPHP) in rats, following exposure via dosed feed; exposures occur during gestation and lactation and for three months after weaning. IPP and TPHP are aromatic organo phosphate flame retardants. Increased use is anticipated as this class is replacing other classes of flame retardants. Exposure to IPP and TPHP occurs in the general population via its presence in consumer products and in the environment. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of IPP and TPHP and ultimately supports the mission and goals of DTT and risk assessment activities of other federal agencies. Keywords: toxicity, isopropylated phenol phosphate, dosed feed, flame retardant

本项目的目标是为转化毒理学司（DTT）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及在大鼠通过定量饲料接触异丙基苯酚磷酸盐（IPP）和磷酸三苯酯（TPHP）后进行毒性研究;接触发生在妊娠期和哺乳期以及断奶后三个月。IPP和TPHP是芳香族有机磷酸酯阻燃剂。随着此类阻燃剂取代其他类别的阻燃剂，预计使用量将增加。 通过消费品和环境中的IPP和TPHP，一般人群会暴露于IPP和TPHP。该项目的数据将用于制定关于IPP和TPHP潜在毒性的合理科学结论，并最终支持DTT的使命和目标以及其他联邦机构的风险评估活动。 关键词：毒性、异丙基苯酚磷酸酯、投料、阻燃剂