Conduct of studies to evaluate the subchronic and developmental neurotoxicity of triphenyl phosphate (TPHP) in rats (after perinatal exposure)

本项目的目标是为转化毒理学（DTT）部门的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及通过定量饲料接触磷酸三苯酯（TPHP）后在大鼠体内进行毒性研究;接触发生在妊娠期和哺乳期以及断奶后三个月。TPHP是一种芳香族有机磷酸酯阻燃剂。随着此类阻燃剂取代其他类别的阻燃剂，预计使用量将增加。 一般人群通过消费品和环境中的TPHP暴露于TPHP。该项目的数据将用于制定关于TPHP潜在毒性的合理科学结论，并最终支持DTT的使命和目标以及其他联邦机构的风险评估活动。 关键词：毒性，磷酸三苯酯，投料，阻燃剂

The goal of this project is to provide support of Division of Translational Toxicology (DTT) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity studies of triphenyl phosphate (TPHP)in rats, following exposure via dosed feed; exposures occur during gestation and lactation and for three months after weaning. TPHP is an aromatic organo phosphate flame retardant. Increased use is anticipated as this class is replacing other classes of flame retardants. Exposure to TPHP occurs in the general population via its presence in consumer products and in the environment. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity of TPHP and ultimately supports the mission and goals of DTT and risk assessment activities by other federal agencies. Keywords: toxicity, triphenyl phosphate, dosed feed, flame retardant