Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene in laboratory animals

该项目的目标是为国家毒理学规划司（DNTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理剂而引起的疾病或不利影响。毒性试验是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要进行适当的毒理学研究，以确保得出的数据可靠。本项目涉及对大鼠和小鼠进行全身吸入暴露的-蒎烯的毒性和致癌性研究。-蒎烯存在于松节油和香料中。人类可能通过呼吸的空气、使用个人护理和清洁产品以及木材加工和建筑活动接触到这种物质。该项目的数据将用于对-蒎烯在大鼠和小鼠体内的潜在毒性和致癌性得出合理的科学结论，并最终支持DNTP的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解暴露于-蒎烯所产生的风险因素。

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies of alpha-pinene in rats and mice, with exposure by whole-body inhalation. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed via the air they breathe, through use of personal care and cleaning products as well as in lumber processing and building activities. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of alpha-pinene in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to alpha-pinene. Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene, lung