Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene in laboratory animals

进行研究以评估α-蒎烯对实验动物的毒性和致癌潜力

• 批准号: 10388052
• 负责人: BARNEY SPARROW
• 金额: $ 56.35万
• 依托单位: BATTELLE MEMORIAL INSTITU
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2022-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388052
• 关键词: Adverse effects; Air; Chemicals; Data; Development; Ensure; Environmental Exposure; Evaluation; Exposure to; Flavoring; Goals; Hazard Identification; Hazardous Chemicals; Health; Human; Inhalation; Laboratory Animals; Lung; Mammary gland; Mission; Mus; National Toxicology Program; Pathology; Peer Review; Phase; Rattus; Reporting; Risk Assessment; Risk Factors; Self Care; Toxic effect; Toxicity Tests; Toxicology; Turpentine; carcinogenicity; disorder prevention; public health research; reproductive; sound

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies of alpha-pinene in rats and mice, with exposure by whole-body inhalation. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed via the air they breathe, through use of personal care and cleaning products as well as in lumber processing and building activities. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of alpha-pinene in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to alpha-pinene. Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene, lung

该项目的目标是为国家毒理学规划司（DNTP）的危害识别活动提供支持，这些活动旨在预防因环境暴露于化学或物理制剂而引起的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它有助于确定对人类健康有害的化学品。需要适当进行毒理学研究，以确保所得数据可靠。该项目涉及在大鼠和小鼠体内进行α-蒎烯的毒性和致癌性研究，并通过全身吸入进行接触。α-蒎烯存在于松节油、调味品和香水中。人类可能通过呼吸的空气、使用个人护理和清洁产品以及木材加工和建筑活动而接触。该项目的数据将用于制定关于α-蒎烯在大鼠和小鼠中的潜在毒性和致癌性的合理科学结论，并最终支持DNTP的使命和目标以及其他联邦机构的风险评估活动。此外，公众可以充分了解接触α-蒎烯引起的风险因素。 关键词：毒性，致癌性，吸入，α-蒎烯，肺