Conduct of studies to evaluate the toxic and carcinogenic potential of alpha-pinene in laboratory animals

该项目的目标是为国家毒理学计划(DNTP)危险识别活动提供支持，旨在预防因环境暴露于化学或物理制剂而导致的疾病或不良影响。毒性测试是公共卫生研究的一个重要方面，因为它用于识别对人类健康有害的化学品。需要适当地进行毒理学研究，以确保结果数据是可靠的。该项目涉及对大鼠和小鼠的毒性和致癌性研究，通过全身吸入暴露。α-蒎烯存在于松节油、调味品和香水中。人类可能通过呼吸空气、使用个人护理和清洁产品以及在木材加工和建筑活动中接触到空气。该项目的数据将用于就α-蒎烯对大鼠和小鼠的潜在毒性和致癌性得出合理的科学结论，并最终支持dNTP的使命和目标以及其他联邦机构的风险评估活动。此外，公众还可以充分了解因接触α-蒎烯而产生的危险因素。 关键词：毒性、致癌性、吸入、α-蒎烯、肺

The goal of this project is to provide support of the Division of the National Toxicology Program (DNTP) hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents. Toxicity testing is an important aspect of public health research in that it serves to identify chemicals that are hazardous to human health. Proper conduct of toxicology studies is required to ensure that the resulting data are reliable. This project involves the conduct of toxicity and carcinogenicity studies of alpha-pinene in rats and mice, with exposure by whole-body inhalation. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed via the air they breathe, through use of personal care and cleaning products as well as in lumber processing and building activities. The data from this project will be used in the development of sound, scientific conclusions about the potential toxicity and carcinogenicity of alpha-pinene in rats and mice and ultimately supports the mission and goals of DNTP and risk assessment activities of other federal agencies. In addition, the public can be adequately informed about risk factors arising from exposure to alpha-pinene. Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene, lung