Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
基本信息
- 批准号:10392478
- 负责人:
- 金额:$ 73.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-13 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescenceAdolescent and Young AdultAgeAlabamaAspirate substanceBacteriaBehaviorBehavioralBiological FactorsCarbohydratesCaringCariogenic DietCaucasiansCessation of lifeChronicClinicalCystic FibrosisDataDentalDental HygieneDental PlaqueDental cariesDentistryDentistsDiagnosticDiseaseEnrollmentEnvironmentEpidemiologyEvidence based interventionGeneral PopulationGingivitisHealthHealth behaviorImpairmentIncidenceIntakeInterventionLifeLife ExpectancyLinkLungLung diseasesMeasuresMechanical ventilationMedicalMethodsMicrobiologyModelingModernizationMouth DiseasesMucociliary ClearanceNorth CarolinaObstructive Lung DiseasesOralOral cavityOral healthOutcomePathogenicityPathway interactionsPatientsPediatric HospitalsPneumoniaPopulationPrevalencePreventionPreventivePreventive dental carePulmonary Cystic FibrosisPulmonary Function Test/Forced Expiratory Volume 1Quality of lifeRandomized Clinical TrialsRefluxRespiratory Tract InfectionsRiskRisk FactorsSalivaSiteSourceSputumStandardizationStomachStreptococcus mutansTimeUniversitiesVisitWeightage groupbasechildren with cystic fibrosiscohortcystic fibrosis patientsdisorder preventiondysbiosisearly adolescencefunctional declinehigh riskimprovedloss of functionlung injurylung microbiomemicrobiomemicrobiome analysisoral bacteriaoral microbiomepathogenic bacteriapeerprematurepreventpreventive interventionprospectivepulmonary functionpulmonary function declinerespiratoryrespiratory health
项目摘要
Abstract
Cystic fibrosis (CF) is the most common life-limiting autosomal recessive disease in Caucasians. Impaired
mucociliary clearance predisposes individuals with CF to chronic respiratory infections, resulting in progressive
lung damage and premature death. We and others have shown that oral bacteria infect the lungs in individuals
with CF at high concentrations. Caries and gingivitis are associated with an increased abundance of
pathogenic and often proinflammatory intraoral bacteria that can be aspirated. Dental plaque flora can cause
pneumonia, for example in mechanically-ventilated patients. Given the broader evidence of oral-respiratory
links, it is surprising that the association between oral diseases and respiratory health in CF has never been
evaluated, even though there is a plausible microbiological mechanism. The overall hypothesis of this proposal
is that oral diseases, defined as caries and gingivitis, are potentially modifiable contributors to lung disease in
CF. In this 5-year observational U01, we will enroll 210 adolescents and young adults with CF ages 12 to 30
years at 3 sites: Seattle Children’s Hospital, the University of North Carolina Chapel Hill, and the University of
Alabama at Birmingham. The study will involve 3 study visits over 24 months. We will obtain quantitative and
qualitative data on risk factors for oral diseases; perform a standardized assessment of caries and gingivitis;
evaluate respiratory health outcomes; and collect sputum, saliva, and plaque for microbiome analyses. The
Aims are to: (1) Describe the prevalence and incidence of oral diseases in adolescents and young
adults with CF and identify corresponding risk factors with an emphasis on how to improve key oral
health behaviors; (2) Evaluate cross-sectional and longitudinal associations between oral diseases and
respiratory outcomes; and (3) Explore microbiome pathways that link oral and respiratory health. The
proposed study will be the largest and first longitudinal CF oral health study to date, and the first to evaluate
respiratory outcomes associated with oral diseases in CF. Our long-term objective is to develop behavioral
randomized clinical trials for adolescents and young adults with CF to prevent oral diseases and protect
respiratory health. We also seek to elucidate mechanisms that explain the systemic health consequences of
oral diseases. More broadly, our approach provides a framework for improving the oral health of medically
compromised populations through critical epidemiologic inquiry and evidence-based interventions.
摘要
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Donald Leslie Chi其他文献
Donald Leslie Chi的其他文献
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{{ truncateString('Donald Leslie Chi', 18)}}的其他基金
Testing a Mobile App to Improve Toothbrushing Skills and Habits in Teens with Autism.
测试移动应用程序以提高自闭症青少年的刷牙技能和习惯。
- 批准号:
10738080 - 财政年份:2023
- 资助金额:
$ 73.35万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
- 批准号:
10181640 - 财政年份:2021
- 资助金额:
$ 73.35万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
- 批准号:
10772418 - 财政年份:2021
- 资助金额:
$ 73.35万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions.
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施。
- 批准号:
10664785 - 财政年份:2021
- 资助金额:
$ 73.35万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
- 批准号:
10571699 - 财政年份:2021
- 资助金额:
$ 73.35万 - 项目类别:
Reducing Sugared Fruit Drinks in Alaska Native Children
减少阿拉斯加原住民儿童的含糖水果饮料
- 批准号:
10115247 - 财政年份:2020
- 资助金额:
$ 73.35万 - 项目类别:
Reducing Sugared Fruit Drinks in Alaska Native Children
减少阿拉斯加原住民儿童的含糖水果饮料
- 批准号:
9924503 - 财政年份:2019
- 资助金额:
$ 73.35万 - 项目类别:
Reducing Sugared Fruit Drinks in Alaska Native Children
减少阿拉斯加原住民儿童的含糖水果饮料
- 批准号:
10192501 - 财政年份:2019
- 资助金额:
$ 73.35万 - 项目类别:
Developing Topical Fluoride Hesitancy Measures for Causal Modeling and Intervention Research
为因果建模和干预研究制定局部氟化物犹豫措施
- 批准号:
10237416 - 财政年份:2018
- 资助金额:
$ 73.35万 - 项目类别:
Developing Topical Fluoride Hesitancy Measures for Causal Modeling and Intervention Research
为因果建模和干预研究制定局部氟化物犹豫措施
- 批准号:
9768993 - 财政年份:2018
- 资助金额:
$ 73.35万 - 项目类别:
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