Neurocognitive Mechanisms underlying Episodic Memory Functioning in children with Autism Spectrum Disorder

自闭症谱系障碍儿童情景记忆功能的神经认知机制

• 批准号: 10394714
• 负责人: Lindsey Mooney
• 金额: $ 3.92万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10394714
• 关键词: Adolescence; Adolescent; Affect; Area; Behavioral; Centers for Disease Control and Prevention (U.S.); Child; Color; Complex; Control Groups; Cues; Data Analyses; Data Collection; Development; Dorsal; Episodic memory; Event; Exhibits; Experimental Designs; Fellowship; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Hippocampus (Brain); Imaging Techniques; Impairment; Individual; Infant; Intervention; Knowledge; Language; Learning; Location; Memory; Memory impairment; Mental Health; Methodology; Nature; Neuroanatomy; Neurocognitive; Neurodevelopmental Disorder; Neurophysiology - biologic function; Neurosciences Research; Parietal; Performance; Process; Research; Retrieval; Shapes; Social Change; Stream; Structure; Symptoms; Testing; Time; Training; United States; adolescent with autism spectrum disorder; autism spectrum disorder; autistic children; behavioral study; central coherence; cognitive ability; cognitive change; cognitive function; cognitive neuroscience; design; episodic memory impairment; experience; experimental study; individuals with autism spectrum disorder; information processing; insight; memory process; neural correlate; preservation; recruit; skills; spatial memory; spatiotemporal; stem; theories; training opportunity; translational applications; translational potential; visual processing

Project Summary Children and adolescents with Autism Spectrum Disorder (ASD) show deficits in episodic memory, even when they perform within the typical range in assessments of general intellectual functioning. However, no unifying theory has been able to fully capture the nature of these deficits. Most of the currently available accounts emphasize difficulties with complex cognitive abilities suggesting that fragmentary knowledge structures about the self and the world may not provide sufficient foundation for children and adolescents with ASD to retain detailed episodic memories. However, some of these memory difficulties may stem from altered visual processing of basic features of events (e.g., information about event location). The proposed research plan seeks to bridge the gap between the fields of episodic memory and visual processing in ASD, which are believed to be atypical. The proposed application is centered around testing the hypothesis that altered processing in the dorsal visual processing stream is responsible for documented episodic retention for spatial information (Aim 1) and that the behavioral consequences extend to temporal information, but do not extend to event features (e.g., event color or shape) (Aim 2). The pursuit of these aims will provide the opportunity for training in functional Magnetic Resonance Imaging (fMRI) techniques, experimental designs utilized in developmental cognitive neuroscience research, atypical neuroanatomy, neural function in ASD, and potential translational applications of the expected research findings. Relevance for Mental Health. Adolescence is a time of significant cognitive and social change and it is important to establish how those with ASD fare during this period since some evidence suggests that symptoms intensify while other evidence suggests that they may subside. In this context, identifying areas of impaired versus preserved cognitive functioning may be important to recognize aspects of vulnerability and relative strength with implications for adaptive functioning.

项目摘要 患有自闭症谱系障碍（ASD）的儿童和青少年表现出情景记忆的缺陷，即使在 他们在一般智力功能评估中的表现在典型范围内。然而，没有统一 理论已经能够完全捕捉到这些赤字的性质。目前可用的大多数帐户 强调复杂认知能力的困难，这表明关于 自我和世界可能无法为ASD儿童和青少年提供足够的基础， 详细的情节记忆然而，其中一些记忆困难可能源于视觉改变， 事件的基本特征的处理（例如，关于活动地点的信息）。拟议的研究计划 旨在弥合ASD中情景记忆和视觉处理领域之间的差距， 被认为是非典型的。 拟议的应用程序是围绕测试的假设，改变了处理在背视觉 处理流负责记录空间信息的情景保留（目标1）， 行为后果扩展到时间信息，但不扩展到事件特征（例如，事件颜色 或形状）（目标2）。追求这些目标将提供机会，培训功能磁 共振成像（fMRI）技术，用于发展认知神经科学的实验设计 研究，非典型神经解剖学，ASD中的神经功能，以及 预期的研究结果。 与心理健康相关。青春期是认知和社会发生重大变化的时期， 重要的是要确定ASD患者在此期间的表现，因为一些证据表明， 症状加剧，而其他证据表明，他们可能会消退。在这方面， 受损与保留的认知功能可能对认识脆弱性的各个方面很重要， 相对强度与适应功能的影响。