Partners Healthcare Training Program in Precision and Genomic Medicine

精准与基因组医学合作伙伴医疗保健培训计划

• 批准号: 10394807
• 负责人: HEIDI L REHM
• 金额: $ 50.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-22 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10394807
• 关键词: Healthcare; Training Programs; precision genomic medicine

The Partners Training Program in Precision & Genomic Medicine is designed to provide rigorous, interdisciplinary training of postdoctoral scientists in the translational genomic, clinical and computational sciences that are driving a new era of precision and genomic medicine. Our proposal brings together three outstanding components to build a world-class training program genomic medicine: 1) an internationally- recognized faculty of experienced mentors with expertise in precision and genomic medicine across a broad range of disciplines, 2) outstanding institutional resources bridging clinical, genomic, and data sciences, and 3) deep engagement with cutting edge, collaborative initiatives at the regional, national, and international levels to provide rich training experiences. The program will have a particular emphasis in four domains of precision and genomic medicine in which the participating institutions and faculty have become national and international leaders: 1) medical genetics/genomics; 2) data science; 3) molecular medicine; and 4) implementation science. The program begins with “embedded rotations” in relevant laboratory and clinical settings and then provides a structured but flexible curriculum of didactic courses, case conferences, journal clubs, seminars, and retreats covering scientific foundations, essential skills for career development, team science, and RCR training. A core element of the training program is a mentored research experience that will include mentored research projects and career development guidance. We have assembled a group of 43 established and highly collaborative faculty mentors across the Partners Healthcare System (including Massachusetts General Hospital and Brigham and Women’s Hospital) as well as Harvard Medical School, MIT, the Broad Institute, and Boston Children’s Hospital. Trainees will work closely with a mentorship team comprising a Primary Mentor (in their primary domain of interest), a Secondary Mentor (in a secondary domain), and the two Program Directors. An individualized training program will be developed and monitored in conjunction with the mentorship team. Trainees will also benefit from access to extensive data networks and resources in which our faculty have played leading roles including the eMERGE network, TOPmed, the All of Us Research Program, the Partners Biobank, gnoMAD/ExAC, the Center for Common Disease Genetics, the Center for Mendelian Disease Genomics, the Undiagnosed Diseases Network, and others. Program oversight will include guidance from a Steering Committee of senior faculty mentors and an External Advisory Committee of nationally-renowned leaders spanning the four domains of precision and genomic medicine research. The program is geared toward physician-scientists as well as PhD or equivalent scientists intending to develop careers in precision or genomic medicine research. Trainees will be supported for two years and the program will begin with two fellows in Year 1, increasing to six by Year 4 and beyond. At the completion of this fellowship, trainees will be well-prepared to launch independent research careers in genomic medicine.

精准与基因组医学合作伙伴培训计划旨在提供严格的， 博士后科学家在翻译基因组学，临床和计算的跨学科培训 这些科学正在推动精确和基因组医学的新时代。我们的建议汇集了三个 优秀的组成部分，以建立一个世界一流的培训计划基因组医学：1）一个国际- 公认的教师经验丰富的导师与专业知识，在精密和基因组医学在广泛的 学科范围，2）连接临床，基因组学和数据科学的优秀机构资源，以及3） 深入参与区域、国家和国际层面的前沿合作倡议， 丰富的培训经验。该计划将特别强调精度和 基因组医学，其中参与机构和教师已成为国家和国际 领导者：1）医学遗传学/基因组学; 2）数据科学; 3）分子医学; 4）实施科学。 该计划开始与“嵌入式旋转”在相关的实验室和临床设置，然后提供了一个 结构化但灵活的教学课程，案例会议，期刊俱乐部，研讨会和务虚会 涵盖科学基础、职业发展的基本技能、团队科学和RCR培训。一 培训计划的核心要素是指导研究经验，其中包括指导研究 项目和职业发展指导。我们召集了一个43人的小组， 合作伙伴医疗保健系统（包括马萨诸塞州综合医院）的协作教师导师 医院和布里格姆妇女医院）以及哈佛医学院、麻省理工学院、布罗德研究所和 波士顿儿童医院学员将与一个由一名小学导师（ 他们感兴趣的主要领域），一个二级导师（在二级领域），和两个计划主任。 一个个性化的培训计划将与指导团队一起开发和监测。 学员还将受益于访问广泛的数据网络和资源，其中我们的教师有 发挥了领导作用，包括eMERGE网络，TOPmed，我们所有的研究计划，合作伙伴 生物库，gnoMAD/ExAC，常见疾病遗传学中心，孟德尔疾病中心 基因组学，未诊断疾病网络，以及其他。计划监督将包括来自 高级教师指导委员会和全国知名的外部咨询委员会 领导者横跨精密和基因组医学研究的四个领域。该计划是面向 对医生科学家以及博士或同等科学家打算发展事业的精度或 基因组医学研究。学员将获得两年的支持，该计划将开始两年 研究员在第一年，增加到六年4及以后。在完成这项研究后，受训人员将 为在基因组医学领域开展独立研究事业做好了充分准备。