Partners Healthcare Training Program in Precision and Genomic Medicine

精准和基因组医学合作伙伴培训计划旨在提供严格的、 翻译基因组、临床和计算领域博士后科学家的跨学科培训 这些科学正在推动精准和基因组医学的新时代。我们的提案汇集了三个 打造世界一流的基因组医学培训计划的优秀组成部分：1)国际- 公认的经验丰富的导师队伍，在精确度和基因组医学方面拥有广泛的专业知识 学科范围，2)连接临床、基因组和数据科学的杰出机构资源，以及3) 深度参与区域、国家和国际层面的前沿协作计划，以 提供丰富的培训经验。该计划将特别强调四个领域的精度和 参与的机构和教员已成为全国性和国际性的基因组医学 领导：1)医学遗传学/基因组学；2)数据科学；3)分子医学；4)实施科学。 该计划首先在相关的实验室和临床环境中进行“嵌入式轮换”，然后提供 有组织但灵活的教学课程、案例会议、期刊俱乐部、研讨会和务虚会 涵盖科学基础、职业发展的基本技能、团队科学和RCR培训。一个 培训计划的核心要素是有指导的研究体验，其中包括有指导的研究 项目和职业发展指导。我们已经组建了一个由43名资深人士组成的团队 合作伙伴医疗系统(包括马萨诸塞州综合医院)的协作式教师导师 医院和布里格姆妇女医院)以及哈佛医学院、麻省理工学院、布罗德研究所和 波士顿儿童医院。学员将与一个由一名初级导师组成的导师团队密切合作(在 他们感兴趣的主要领域)、一个次要导师(在次要领域中)和两个计划总监。 将与指导团队一起制定和监测个性化培训计划。 学员还将受益于我们教员拥有的广泛的数据网络和资源 发挥了领导作用，包括Emerge网络、TOPmed、我们所有人研究计划、合作伙伴 生物库、gnoMAD/ExAC、常见病遗传学中心、孟德尔疾病中心 基因组学、未诊断疾病网络和其他。计划监督将包括来自 资深教师导师指导委员会和全国知名的 横跨精准和基因组医学研究四个领域的领导者。这项计划是适当的。 面向内科科学家以及博士或同等级别的科学家，希望在精密或机械领域发展事业 基因组医学研究。学员将获得为期两年的支持，该计划将从两年开始 1年级的研究员人数，到4年级及以后增加到6人。在完成这一奖学金后，受训人员将 为开展基因组医学的独立研究事业做好充分准备。

The Partners Training Program in Precision & Genomic Medicine is designed to provide rigorous, interdisciplinary training of postdoctoral scientists in the translational genomic, clinical and computational sciences that are driving a new era of precision and genomic medicine. Our proposal brings together three outstanding components to build a world-class training program genomic medicine: 1) an internationally- recognized faculty of experienced mentors with expertise in precision and genomic medicine across a broad range of disciplines, 2) outstanding institutional resources bridging clinical, genomic, and data sciences, and 3) deep engagement with cutting edge, collaborative initiatives at the regional, national, and international levels to provide rich training experiences. The program will have a particular emphasis in four domains of precision and genomic medicine in which the participating institutions and faculty have become national and international leaders: 1) medical genetics/genomics; 2) data science; 3) molecular medicine; and 4) implementation science. The program begins with “embedded rotations” in relevant laboratory and clinical settings and then provides a structured but flexible curriculum of didactic courses, case conferences, journal clubs, seminars, and retreats covering scientific foundations, essential skills for career development, team science, and RCR training. A core element of the training program is a mentored research experience that will include mentored research projects and career development guidance. We have assembled a group of 43 established and highly collaborative faculty mentors across the Partners Healthcare System (including Massachusetts General Hospital and Brigham and Women’s Hospital) as well as Harvard Medical School, MIT, the Broad Institute, and Boston Children’s Hospital. Trainees will work closely with a mentorship team comprising a Primary Mentor (in their primary domain of interest), a Secondary Mentor (in a secondary domain), and the two Program Directors. An individualized training program will be developed and monitored in conjunction with the mentorship team. Trainees will also benefit from access to extensive data networks and resources in which our faculty have played leading roles including the eMERGE network, TOPmed, the All of Us Research Program, the Partners Biobank, gnoMAD/ExAC, the Center for Common Disease Genetics, the Center for Mendelian Disease Genomics, the Undiagnosed Diseases Network, and others. Program oversight will include guidance from a Steering Committee of senior faculty mentors and an External Advisory Committee of nationally-renowned leaders spanning the four domains of precision and genomic medicine research. The program is geared toward physician-scientists as well as PhD or equivalent scientists intending to develop careers in precision or genomic medicine research. Trainees will be supported for two years and the program will begin with two fellows in Year 1, increasing to six by Year 4 and beyond. At the completion of this fellowship, trainees will be well-prepared to launch independent research careers in genomic medicine.