ChicAgo Center for Health and EnvironmenT (CACHET)

1.总体：摘要 这是《芝加哥卫生与健康中心》第一份竞争性更新提案的修订版 环境(威望)“--位于芝加哥的第一个NIH P30环境健康科学核心中心 芝加哥大学(UofC)和芝加哥大学于2017年建立平等合作伙伴关系 伊利诺伊州大学芝加哥分校(UIC)。两所大学之间的协同伙伴关系具有互补性 优势，威望促进临床医生、实验室和人群中的多学科EHS研究 科学家将评估、描绘并最终减少居民之间与环境健康有关的差距 芝加哥和更远的地方。芝加哥专门的EHS研究中心的继续存在是有深度的- 根深蒂固的环境和社会不平等及其相关的人口健康后果 组。在这种背景下，威望的使命是阐明生物、社会和行为 相关的城市环境暴露与人类疾病之间的基础，并将 以减少我们社区内的健康不平等现象。我们的总体目标是减轻环境污染 芝加哥及其他地区居民与健康有关的差距。虽然有一些EHS研究 在建立Cachet之前在这两个机构；在过去3.5年中，Cachet整合了这一点 研究，将研究人员聚集在一起，正式确定并指导机构内和机构间的合作，以及 显著增强的EHS研究支持芝加哥地区的基础设施。具体地说，Cachet有 建立生物标志物和微生物核心、动态试点项目计划(PPP)、充满活力的社区 项目核心(CEC)和高度可转换的综合健康科学设施核心(IHSFC)-所有这些都是新的 芝加哥地区。在这很短的时间内，尽管新冠肺炎大流行，但Cachet已经取得了 对跨学科和机构间合作、多部门伙伴关系产生积极影响 社区/城市/州机构和翻译的EHS发现。充分利用我们的进步和经验教训 到目前为止，为了回应评审员对我们第一次重新提交的批评，我们正在通过以下方式向前迈进：i)精简 Cachet焦点小组结构，以改善互动、协同和翻译，ii)更好地利用UofC- UIC的互补性和体制基础设施，以最大限度地提高声望效率，三)回应P30 RFA对翻译性EHS研究的新强调，三)处理NIEHS战略任务，以及，四)处理 跨国家卫生研究院关于EHS研究中结构性种族主义的倡议。我们已经用新的领导层改革了CEC 和一个以社区为中心的议程；我们通过将 以前的‘Biomarkers’和Microbiome‘核心具有更好的访问其他机构Omics核心(非 由Cachet提供资金)；我们改进了IHSFC，以增强其服务，以获得和利用大量队列 由威望成员建立和领导；我们在芝加哥增强了EH研究能力的多样性 通过试点项目和量身定做的职业发展。

1. OVERALL: ABSTRACT This is the revised submission of the first competing renewal proposal for the “ChicAgo Center for Health and EnvironmenT (CACHET)” – the first NIH P30 Environmental Health Sciences (EHS) Core Center in the Chicago area established in 2017 with an equal partnership between the University of Chicago (UofC) and the University of Illinois at Chicago (UIC). With synergistic partnership between the two universities with complementary strengths, CACHET promotes multidisciplinary EHS research among clinician, laboratory, and population scientists to evaluate, delineate, and ultimately reduce environmental health related disparities among residents of Chicago and beyond. The continuation of a dedicated EHS research center in Chicago is warranted by deep- rooted environmental and social inequalities and their associated health outcomes across population sub- groups. In this context, the CACHET mission is to elucidate biological, social, and behavioral underpinnings between relevant urban environmental exposures and human disease and translate the findings to reduce health inequities within our communities. Our overall goal is to mitigate environmental health-related disparities among residents of Chicago and beyond. While there was some EHS research at both institutions prior to the establishment of CACHET; over the past 3.5 years, CACHET has integrated this research, brought researchers together, formalized and steered intra- and inter-institutional collaborations, and significantly enhanced EHS research support infrastructure in the Chicago area. Specifically, CACHET has established Biomarkers and Microbiome Cores, a dynamic Pilot Project Program (PPP), a vibrant Community Engagement Core (CEC), and a highly translational Integrated Health Sciences Facility Core (IHSFC) – all new to the Chicago area. Within this short time frame, and despite the COVID-19 pandemic, CACHET has made positive impacts on interdisciplinary and inter-institutional collaborations, multi-sectorial partnerships among community/city/state agencies, and translational EHS discoveries. Leveraging our progress and lessons learned so far, and responding to reviewers’ critique of our first resubmission, we are moving forward by i) streamlining CACHET focus group structure to improve interactions, synergy, and translation, ii) better leveraging the UofC- UIC complementarity and institutional infrastructure to maximize CACHET efficiency, iii) responding to the P30 RFA new emphasis on translational EHS research, iii) addressing NIEHS strategic mission, and, iv) addressing the trans-NIH initiative on structural racism on EHS research. We have revamped the CEC with new leadership and a community-focused agenda; we formed a “Environmental Biomarkers Core (EBC)” by merging the previous ‘Biomarkers’ and Microbiome’ Cores with enhanced access to other institutional Omics Cores (not funded by CACHET); we refined the IHSFC to augment its services to access and leverage large cohorts established and led by CACHET members; and we have enhanced diversity in EH research capacity in Chicago through pilot projects and tailored career development.