ChicAgo Center for Health and EnvironmenT (CACHET)

1.总体：摘要 这是修改后的提交的第一个竞争性的更新建议的“芝加哥卫生和健康中心”， EnvironmentT（CACHET）”--芝加哥首个NIH P30环境健康科学（EHS）核心中心 该地区成立于2017年，芝加哥大学（UofC）和大学之间建立了平等的合作关系 伊利诺伊州芝加哥（UIC）。两所大学之间的协同合作具有互补性 CACHET在临床医生、实验室和人群中促进多学科的EHS研究 科学家评估，划定，并最终减少居民之间的环境健康相关的差距 芝加哥和更远的地方。继续在芝加哥设立专门的EHS研究中心是有理由的， 根深蒂固的环境和社会不平等及其相关的健康结果， 组在这种背景下，CACHET的使命是阐明生物学、社会学和行为学 相关城市环境暴露与人类疾病之间的联系， 减少我们社区内的卫生不公平现象。我们的总体目标是减轻环境 芝加哥及其他地区居民之间与健康相关的差异。虽然有一些EHS研究 在建立CACHET之前，这两个机构都有;在过去的3.5年里，CACHET已经整合了这一点， 研究，将研究人员聚集在一起，正式化并指导机构内和机构间的合作， 显著增强了芝加哥地区的EHS研究支持基础设施。具体而言，CACHET 建立了生物标志物和微生物组核心，一个充满活力的试点项目计划（PPP），一个充满活力的社区 参与核心（CEC）和高度转化的综合健康科学设施核心（IHSFC）-全部是新的 到芝加哥地区。在这短短的时间内，尽管COVID-19大流行，CACHET已经取得了 对跨学科和机构间合作、跨部门伙伴关系以及 社区/城市/国家机构，以及翻译EHS发现。利用我们的进展和经验教训 到目前为止，为了回应评审员对我们第一次重新提交的批评，我们正在通过i）精简来向前迈进 CACHET焦点小组结构，以改善互动，协同作用和翻译，ii）更好地利用UofC- UIC的互补性和机构基础设施，以最大限度地提高CACHET的效率，iii）响应P30 RFA新的重点是转化EHS研究，iii）解决NIEHS战略使命，iv）解决 关于EHS研究的结构性种族主义的跨NIH倡议。我们用新的领导层对CEC进行了改组 和一个以社区为中心的议程;我们通过合并 先前的“生物标志物”和微生物组“核心，增强了对其他机构组学核心的访问（不 由CACHET资助）;我们改进了IHSFC，以增强其服务，从而访问和利用大型队列 由CACHET成员建立和领导;我们增强了芝加哥EH研究能力的多样性 通过试点项目和有针对性的职业发展。

1. OVERALL: ABSTRACT This is the revised submission of the first competing renewal proposal for the “ChicAgo Center for Health and EnvironmenT (CACHET)” – the first NIH P30 Environmental Health Sciences (EHS) Core Center in the Chicago area established in 2017 with an equal partnership between the University of Chicago (UofC) and the University of Illinois at Chicago (UIC). With synergistic partnership between the two universities with complementary strengths, CACHET promotes multidisciplinary EHS research among clinician, laboratory, and population scientists to evaluate, delineate, and ultimately reduce environmental health related disparities among residents of Chicago and beyond. The continuation of a dedicated EHS research center in Chicago is warranted by deep- rooted environmental and social inequalities and their associated health outcomes across population sub- groups. In this context, the CACHET mission is to elucidate biological, social, and behavioral underpinnings between relevant urban environmental exposures and human disease and translate the findings to reduce health inequities within our communities. Our overall goal is to mitigate environmental health-related disparities among residents of Chicago and beyond. While there was some EHS research at both institutions prior to the establishment of CACHET; over the past 3.5 years, CACHET has integrated this research, brought researchers together, formalized and steered intra- and inter-institutional collaborations, and significantly enhanced EHS research support infrastructure in the Chicago area. Specifically, CACHET has established Biomarkers and Microbiome Cores, a dynamic Pilot Project Program (PPP), a vibrant Community Engagement Core (CEC), and a highly translational Integrated Health Sciences Facility Core (IHSFC) – all new to the Chicago area. Within this short time frame, and despite the COVID-19 pandemic, CACHET has made positive impacts on interdisciplinary and inter-institutional collaborations, multi-sectorial partnerships among community/city/state agencies, and translational EHS discoveries. Leveraging our progress and lessons learned so far, and responding to reviewers’ critique of our first resubmission, we are moving forward by i) streamlining CACHET focus group structure to improve interactions, synergy, and translation, ii) better leveraging the UofC- UIC complementarity and institutional infrastructure to maximize CACHET efficiency, iii) responding to the P30 RFA new emphasis on translational EHS research, iii) addressing NIEHS strategic mission, and, iv) addressing the trans-NIH initiative on structural racism on EHS research. We have revamped the CEC with new leadership and a community-focused agenda; we formed a “Environmental Biomarkers Core (EBC)” by merging the previous ‘Biomarkers’ and Microbiome’ Cores with enhanced access to other institutional Omics Cores (not funded by CACHET); we refined the IHSFC to augment its services to access and leverage large cohorts established and led by CACHET members; and we have enhanced diversity in EH research capacity in Chicago through pilot projects and tailored career development.