ChicAgo Center for Health and EnvironmenT (CACHET)

1.总体摘要 这是一份新的意见书，旨在建立“芝加哥健康与环境中心(CACHET)”--第一个 位于芝加哥地区的NIH P30环境健康科学核心中心与 芝加哥大学(UofC)-全国领先的私立大学和伊利诺伊大学芝加哥分校 (UIC)-伊利诺伊州领先的公立大学。纪念章将由来自18个国家的69名成员组成 这两所互补的合作大学的7个学院/研究所的系。威望将促进 临床医生、实验室和人群之间的多学科环境健康协同研究 科学家将评估、描绘并最终缩小居民之间与环境健康有关的差距 芝加哥和更远的地方。在芝加哥需要一个专门的环境健康研究中心是 突出表现为在多种疾病和结果中观察到的不成比例的种族/族裔健康不平衡。 在这种情况下，声望使命是“阐明生物、社会和经济基础。 相关的城市环境暴露与人类疾病之间的关系，并将研究结果转化为 减少我们社区内的健康不平等现象。因此，我们的主旋律是“减轻 环境健康方面的差距。“为了完成我们的任务，Cachet将组织五个 多学科重点小组：空气、水和土壤污染--解决与恶劣的空气、土壤和/或 水质.暴露、敏感性和风险的生物标记物.阐明环境暴露如何 由于个体遗传和表观遗传差异而增加疾病风险；环境致癌 阐明环境效应物质促进癌症的具体机制；内分泌和代谢 疾病-确定环境暴露如何在易感窗口起作用，以推动 内分泌和代谢动态平衡；环境影响的经济和社会决定因素 政策--在评估减少和减少接触时考虑经济影响和社会因素 告知政策。这一结构将允许开发交叉的综合研究主题 重点群体，特别强调城市问题和种族/族裔健康失衡。纪念碑 多学科研究将通过四个设施核心来支持，这些核心将利用专业知识和 来自这两个机构的设施。这包括所需的社区外展和参与核心 (COEC)和综合健康科学设施核心(IHSFC)与生物标记物核心(BC)和 为响应威望的研究需求而创建的统计与建模工具核心(SMFC) 调查人员。Cachet将通过资助试点项目和促进职业发展来建设EHS的能力 在环境研究方面。总体而言，由威望策划的研究将为政策决策提供信息 并减少芝加哥及其他地区的健康差距。

1. OVERALL ABSTRACT This is a new submission to establish the “ChicAgo Center for Health and EnvironmenT (CACHET)” – the first NIH P30 Environmental Health Sciences Core Center in the Chicago area and a partnership between the University of Chicago (UofC) – a leading private university in the nation and the University of Illinois at Chicago (UIC) – the leading public university in Illinois. CACHET will be comprised of 69 members from 18 Departments across 7 colleges/institutes at the two complementary partner Universities. CACHET will promote synergistic, multidisciplinary environmental health research between the clinician, laboratory and population scientists to evaluate, delineate and ultimately reduce environmental health related disparities among residents of Chicago and beyond. The need for a dedicated environmental health research center in Chicago is highlighted by a disproportionate racial/ethnic health imbalance observed for multiple diseases and outcomes. In this context, the CACHET mission is to “elucidate the biological, social and economic underpinnings between relevant urban environmental exposures and human disease and translate the findings to reduce health inequities within our communities.” As such, our overarching theme is “Mitigating Disparities in Environmental Health.” To accomplish our mission, CACHET will organize five multidisciplinary focus groups: Air, Water & Soil Pollution- to address diseases related to poor air, soil and/or water quality; Biomarkers of Exposure, Susceptibility and Risk- to elucidate how environmental exposures confer risk for disease due to individual genetic and epigenetic differences; Environmental Carcinogenesis- to elucidate specific mechanisms of environmental effectors that promote cancer; Endocrine and Metabolic Diseases- to determine how environmental exposures act at windows of susceptibility to drive disequilibrium in endocrine and metabolic homeostasis; and Economic and Social Determinants of Environmental Effects and Policy- such that the economic impacts and social factors are considered in assessing exposure mitigation and informing policy. This structure will permit the development of integrated research themes that cut across focus groups, with a particular emphasis on urban issues and racial/ethnic health imbalances. CACHET multidisciplinary research will be supported through four facility cores that will leverage the expertise and facilities from the two institutions. This includes the required Community Outreach and Engagement Core (COEC) and Integrated Health Sciences Facility Core (IHSFC) combined with the Biomarkers Core (BC) and the Statistics & Modeling Facility Core (SMFC) created in response to the research needs of CACHET investigators. CACHET will build capacity in EHS by funding pilot projects and promoting career development in environmental research. Overall, research orchestrated by CACHET will inform the decisions of policy makers and reduce health disparities in Chicago and beyond.