ChicAgo Center for Health and EnvironmenT (CACHET)

1.总体摘要 这是一个新的提交，以建立“芝加哥健康与环境中心（CACHET）”-第一个 美国国立卫生研究院P30环境健康科学核心中心在芝加哥地区和之间的伙伴关系， 芝加哥大学（UofC）--美国领先的私立大学，伊利诺伊大学芝加哥分校 (UIC)- 伊利诺伊州领先的公立大学CACHET将由来自18个国家的69名成员组成 两所互补合作大学的7所学院/研究所的部门。CACHET将促进 临床医生，实验室和人群之间的协同，多学科环境卫生研究 科学家评估，描绘并最终减少居民之间与环境健康相关的差异 在芝加哥和其他地方。在芝加哥需要一个专门的环境健康研究中心， 在多种疾病和结果中观察到的不成比例的种族/民族健康不平衡突出了这一点。 在这方面，CACHET的使命是“阐明生物、社会和经济基础 相关城市环境暴露与人类疾病之间的关系，并将研究结果转化为 减少我们社区内的卫生不平等。”因此，我们的首要主题是“减轻 环境卫生的差异”。为了完成我们的使命，CACHET将组织五个 多学科重点小组：空气、水和土壤污染-解决与空气、土壤和/或 水质;暴露、易感性和风险的生物标志物-阐明环境暴露如何 由于个体遗传和表观遗传差异而赋予疾病风险;环境致癌作用- 阐明促进癌症的环境效应物的具体机制;内分泌和代谢 疾病-确定环境暴露如何在易感性窗口中发挥作用，以驱动 环境影响的经济和社会决定因素， 政策-以便在评估暴露缓解措施时考虑经济影响和社会因素， 通知政策。这一结构将允许开发跨学科的综合研究主题 重点小组，特别强调城市问题和种族/民族健康不平衡问题。纪念印 多学科研究将通过四个设施核心得到支持，这些设施将利用专业知识， 两个机构的设施。这包括所需的社区外展和参与核心 （COEC）和综合健康科学设施核心（IHSFC）结合生物标志物核心（BC）， 为响应CACHET的研究需求而创建的统计与建模设施核心（SMFC） investigators. CACHET将通过资助试点项目和促进职业发展来建设EHS能力 在环境研究中。总的来说，CACHET组织的研究将为政策决策提供信息。 制造商和减少健康差距在芝加哥和超越。

1. OVERALL ABSTRACT This is a new submission to establish the “ChicAgo Center for Health and EnvironmenT (CACHET)” – the first NIH P30 Environmental Health Sciences Core Center in the Chicago area and a partnership between the University of Chicago (UofC) – a leading private university in the nation and the University of Illinois at Chicago (UIC) – the leading public university in Illinois. CACHET will be comprised of 69 members from 18 Departments across 7 colleges/institutes at the two complementary partner Universities. CACHET will promote synergistic, multidisciplinary environmental health research between the clinician, laboratory and population scientists to evaluate, delineate and ultimately reduce environmental health related disparities among residents of Chicago and beyond. The need for a dedicated environmental health research center in Chicago is highlighted by a disproportionate racial/ethnic health imbalance observed for multiple diseases and outcomes. In this context, the CACHET mission is to “elucidate the biological, social and economic underpinnings between relevant urban environmental exposures and human disease and translate the findings to reduce health inequities within our communities.” As such, our overarching theme is “Mitigating Disparities in Environmental Health.” To accomplish our mission, CACHET will organize five multidisciplinary focus groups: Air, Water & Soil Pollution- to address diseases related to poor air, soil and/or water quality; Biomarkers of Exposure, Susceptibility and Risk- to elucidate how environmental exposures confer risk for disease due to individual genetic and epigenetic differences; Environmental Carcinogenesis- to elucidate specific mechanisms of environmental effectors that promote cancer; Endocrine and Metabolic Diseases- to determine how environmental exposures act at windows of susceptibility to drive disequilibrium in endocrine and metabolic homeostasis; and Economic and Social Determinants of Environmental Effects and Policy- such that the economic impacts and social factors are considered in assessing exposure mitigation and informing policy. This structure will permit the development of integrated research themes that cut across focus groups, with a particular emphasis on urban issues and racial/ethnic health imbalances. CACHET multidisciplinary research will be supported through four facility cores that will leverage the expertise and facilities from the two institutions. This includes the required Community Outreach and Engagement Core (COEC) and Integrated Health Sciences Facility Core (IHSFC) combined with the Biomarkers Core (BC) and the Statistics & Modeling Facility Core (SMFC) created in response to the research needs of CACHET investigators. CACHET will build capacity in EHS by funding pilot projects and promoting career development in environmental research. Overall, research orchestrated by CACHET will inform the decisions of policy makers and reduce health disparities in Chicago and beyond.