An integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition

基于单神经元、群体、局部网络和刺激的人类社会认知的综合前额叶研究

• 批准号: 10396104
• 负责人: Ziv Williams
• 金额: $ 82.79万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10396104
• 关键词: Acute; Address; Affect; Amygdaloid structure; Animal Model; Anterior; Area; Behavior; Behavioral; Belief; Bipolar Disorder; Brain; Cognitive; Communities; Complex; Computer Models; Data; Disease; Dorsal; Electrodes; Elements; Emotional; Evaluation; Event; FDA approved; Goals; Growth; Hippocampus (Brain); Human; Individual; Institutional Review Boards; Investigation; Judgment; Lesion; Mental Depression; Mind; Modality; Network-based; Neurons; Participant; Pattern; Performance; Play; Population; Population Analysis; Prefrontal Cortex; Process; Research; Resolution; Role; Schizophrenia; Sensory; Social Behavior; Social Processes; Stroke; Structure; Techniques; Testing; Time; Trauma; Work; autism spectrum disorder; base; cingulate cortex; cognitive function; cognitive process; design; experience; frontal lobe cortex; imaging study; innovation; insight; memory process; microstimulation; novel; prospective; psychosocial; recruit; relating to nervous system; social; social cognition; social neuroscience; theories

An integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition This proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation- based evaluation of the role that the dorsal prefrontal cortex plays in human social cognition. Despite ongoing progress in our understanding of basic elements of social behavior through animal models, astonishingly little is known about the single-neuronal and causal mechanisms that underlie human social cognition. A core network of areas comprising the dorsomedial prefrontal, dorsolateral prefrontal and anterior cingulate cortex of the frontal lobe has been suggested to play a critical role in human social behavior; sub-serving processes that include emotional judgment, social reasoning and theory of mind. Unlike more basic sensorimotor processes, these social processes require individuals not only to represent the observed behavior or actions of others but to also infer their hidden internal states and beliefs which are inherently unobservable and unknown. These higher-order social processes play a central role in human ontogeny and are broadly affected in psychosocial conditions such as schizophrenia, depression and autism spectrum disorder. Yet, despite their importance, extraordinarily little is known about how the activities of neurons in the human brain give rise to these diverse social cognitive functions or what precise role specific prefrontal areas play. Building on our groups unique combined experience in acute single-neuronal recordings from the these dorsal prefrontal areas, social neuroscience and theory, population analyses, computational modeling and real-time stimulation techniques and by using a novel structured multi-set social task, this proposal aims to address, for the first time, vital questions about how social information is processed in humans at the cellular level, what specific cognitive processes are engaged across cortical areas, whether these processes are dissociable from more generalized cognitive mechanisms, how these key computations interrelate and, crucially, what causal contribution do neural activities in these prefrontal areas play in human social cognition at the behavioral level. Together, this systematic cross-modal, inter-disciplinary, multi-institutional collaborative effort promises to provide unprecedented new insights into human social cognition at the cellular level and offer an innovative new framework by which to investigate the prospective contribution of the dorsal prefrontal cortex to psychosocial conditions such as autism spectrum disorder.

基于综合的单神经元，种群，本地网络和基于刺激 人类社会认知的前额叶调查 该提案旨在进行全面的单细胞，人口，局部电路和刺激 - 基于对背额额叶皮层在人类社会认知中起作用的作用的评估。尽管正在进行 在我们通过动物模型对社会行为基本要素的理解中的进步，几乎没有 关于人类社会认知基础的单神经元和因果机制已知。核心 包括背部前额叶，背外侧前额叶和前扣带回皮质的区域网络 有人建议额叶在人类的社会行为中发挥关键作用。子服务过程 包括情感判断，社会推理和心理理论。与更多基本的感觉运动过程不同， 这些社会过程不仅要求个人不仅代表他人的行为或行为，还要求个人 还推断出他们隐藏的内部状态和信念，这些状态本质上是不可观察和未知的。这些 高阶社会过程在人体个体中起着核心作用，在心理社会中受到广泛影响 精神分裂症，抑郁和自闭症谱系障碍等疾病。然而，尽管它们的重要性 关于人脑中神经元的活动如何引起这些多样的多样性 社会认知功能或特定前额叶领域的何种精确作用。以我们的团体为基础 从这些背侧前额叶区域的急性单神经元录音中的综合经验，社会 神经科学与理论，人群分析，计算建模和实时刺激技术 通过使用新颖的结构化多集社交任务，该提案旨在首次解决至关重要的问题 关于在细胞层面人类中如何处理社会信息的问题，什么特定的认知 这些过程是否可以与更广泛的流程分离 认知机制，这些关键计算如何相互关联以及至关重要的因果贡献 这些前额叶地区的神经活动在行为层面上以人类的社会认知发挥作用。一起，这个 系统的跨模式，跨学科的多机构合作努力有望提供 在细胞层面上对人类社会认知的空前新见解，并提供创新的新 框架来研究背前皮层对心理心理的前瞻性贡献 自闭症谱系障碍等疾病。