An integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition

基于单神经元、群体、局部网络和刺激的人类社会认知的综合前额叶研究

• 批准号: 10396104
• 负责人: Ziv Williams
• 金额: $ 82.79万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10396104
• 关键词: Acute; Address; Affect; Amygdaloid structure; Animal Model; Anterior; Area; Behavior; Behavioral; Belief; Bipolar Disorder; Brain; Cognitive; Communities; Complex; Computer Models; Data; Disease; Dorsal; Electrodes; Elements; Emotional; Evaluation; Event; FDA approved; Goals; Growth; Hippocampus (Brain); Human; Individual; Institutional Review Boards; Investigation; Judgment; Lesion; Mental Depression; Mind; Modality; Network-based; Neurons; Participant; Pattern; Performance; Play; Population; Population Analysis; Prefrontal Cortex; Process; Research; Resolution; Role; Schizophrenia; Sensory; Social Behavior; Social Processes; Stroke; Structure; Techniques; Testing; Time; Trauma; Work; autism spectrum disorder; base; cingulate cortex; cognitive function; cognitive process; design; experience; frontal lobe cortex; imaging study; innovation; insight; memory process; microstimulation; novel; prospective; psychosocial; recruit; relating to nervous system; social; social cognition; social neuroscience; theories

An integrated single-neuronal, population-, local network- and stimulation-based prefrontal investigation of human social cognition This proposal aims to undertake a comprehensive single-cellular, population-, local circuit- and stimulation- based evaluation of the role that the dorsal prefrontal cortex plays in human social cognition. Despite ongoing progress in our understanding of basic elements of social behavior through animal models, astonishingly little is known about the single-neuronal and causal mechanisms that underlie human social cognition. A core network of areas comprising the dorsomedial prefrontal, dorsolateral prefrontal and anterior cingulate cortex of the frontal lobe has been suggested to play a critical role in human social behavior; sub-serving processes that include emotional judgment, social reasoning and theory of mind. Unlike more basic sensorimotor processes, these social processes require individuals not only to represent the observed behavior or actions of others but to also infer their hidden internal states and beliefs which are inherently unobservable and unknown. These higher-order social processes play a central role in human ontogeny and are broadly affected in psychosocial conditions such as schizophrenia, depression and autism spectrum disorder. Yet, despite their importance, extraordinarily little is known about how the activities of neurons in the human brain give rise to these diverse social cognitive functions or what precise role specific prefrontal areas play. Building on our groups unique combined experience in acute single-neuronal recordings from the these dorsal prefrontal areas, social neuroscience and theory, population analyses, computational modeling and real-time stimulation techniques and by using a novel structured multi-set social task, this proposal aims to address, for the first time, vital questions about how social information is processed in humans at the cellular level, what specific cognitive processes are engaged across cortical areas, whether these processes are dissociable from more generalized cognitive mechanisms, how these key computations interrelate and, crucially, what causal contribution do neural activities in these prefrontal areas play in human social cognition at the behavioral level. Together, this systematic cross-modal, inter-disciplinary, multi-institutional collaborative effort promises to provide unprecedented new insights into human social cognition at the cellular level and offer an innovative new framework by which to investigate the prospective contribution of the dorsal prefrontal cortex to psychosocial conditions such as autism spectrum disorder.

基于单神经元、群体、局部网络和刺激的集成 人类社会认知的前额叶研究 该提案旨在进行全面的单细胞、群体、局部电路和刺激 基于背侧前额叶皮层在人类社会认知中所起作用的评估。尽管正在进行 我们通过动物模型对社会行为基本要素的理解取得的进展少得惊人 众所周知，人类社会认知的单神经元和因果机制。一个核心 包括背内侧前额叶、背外侧前额叶和前扣带皮层的区域网络 额叶被认为在人类社会行为中发挥着关键作用；子服务流程 包括情感判断、社会推理和心理理论。与更基本的感觉运动过程不同， 这些社会过程要求个人不仅代表他人观察到的行为或行动，而且 还可以推断出他们隐藏的内在状态和信念，这些状态和信念本质上是不可观察和未知的。这些 高阶社会过程在人类个体发育中发挥着核心作用，并广泛影响社会心理 精神分裂症、抑郁症和自闭症谱系障碍等疾病。然而，尽管它们很重要， 关于人脑神经元的活动如何产生这些不同的信息，人们知之甚少。 社会认知功能或特定前额区域发挥的确切作用。以我们团队的独特性为基础 来自这些背侧前额叶区域的急性单神经元记录的综合经验，社会 神经科学和理论、群体分析、计算建模和实时刺激技术 通过使用新颖的结构化多组社会任务，该提案旨在首次解决重要的问题 关于人类如何在细胞水平上处理社会信息的问题，具体的认知是什么？ 过程跨皮层区域参与，这些过程是否与更广义的过程分离 认知机制，这些关键计算如何相互关联，最重要的是，因果贡献是什么 这些前额叶区域的神经活动在行为层面上影响人类的社会认知。在一起，这个 系统性的跨模式、跨学科、多机构协作努力有望提供 在细胞水平上对人类社会认知史无前例的新见解，并提供了一种创新的新方法 调查背侧前额叶皮层对社会心理的预期贡献的框架 自闭症谱系障碍等疾病。