SC COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH)

摘要 南卡罗来纳州改善肌肉骨骼健康的翻译研究中心的总体目标 (SC-TRIMH)是为了增强和扩大克莱姆森大学的生物医学研究能力，以促进 在骨骼和关节疾病方面有出色的多学科、协作和转化性研究。一种新的 翻译研究的科学理念，即虚拟人试验，将通过强大的 计算建模与定量功能验证和评估相结合，以加快 从概念开发到可交付的新疗法、干预措施和设备的过程 肌肉骨骼健康。一个多学科的互动中心，以促进翻译研究 肌肉骨骼健康将通过支持初级研究人员和加强他们的研究来发展 竞争力。具体目标是：1)培训和指导一名最初的五名目标初级干部 研究人员将在NIH资助的肌肉骨骼健康研究方面发展独立的研究生涯；2) 发展和加强研究基础设施的关键领域，通过开发新的核心和 加强现有的，作为平台，增加目标教员的潜力，以 成功竞争NIH资金并与全州范围内的调查人员建立合作关系 研究兴趣；3)通过技术转让促进SC-TRIMH的长期生存能力 严格的评估和改进策略。该中心由一个多学科团队领导，具有以下专业知识 物理学、材料科学、计算机、生物工程、公共卫生、生物学和医学，从而将 来自克莱姆森大学健康研究学院(CUSHR)的资源和学科，并与 格林维尔卫生系统(GHS)。科学核心包括：1)多尺度计算建模核心 利用集群计算、生物信息学和系统生物学为特定患者/样本建模 身体、组织和细胞水平的肌肉骨骼系统，用于开发新的骨骼设备， 精准医学的干预和治疗；2)先进的制造和测试核心，以产生， 使用改进和优化设备、干预和治疗的功能和性能 先进的微观和宏观制造技术；3)提供动物试验的临床前评估核心 和人体身体分析，以评估新设备、干预和治疗方法的体内功能。 这些核心将使最初的5个初级调查员项目能够实施虚拟人的新概念 促进肌肉骨骼健康和促进其国家研究奖竞争力的试验。 广泛的机构支持--包括灵活的资金、新的教员招聘和主要设备 购买-将为中心的长期成功和生存能力提供保障。这一举措充分利用了 克莱姆森大学的现有基础设施，CUSHR，以及它在GHS的创新中心。

SUMMARY The overall goal of the South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) is to enhance and expand the Biomedical Research capacity at Clemson University to promote outstanding multidisciplinary, collaborative, and translational research in bone and joint diseases. A new scientific concept for translational research, i.e. Virtual Human Trials, is to be implemented through powerful computational modeling combined with quantitative functional validation and assessment to expedite the process from concept development to deliverable new therapeutics, interventions, and devices for musculoskeletal health. A multidisciplinary and interactive center to promote translational research for musculoskeletal health is to be developed by supporting junior investigators and enhancing their research competitiveness. The specific aims are to: 1) train and mentor an initial cadre of five targeted junior investigators to develop independent NIH funded research careers in musculoskeletal health research; 2) develop and enhance key areas of research infrastructure through the development of novel cores and enhancement of existing ones, which serve as platforms to increase the potential of the targeted faculty to compete successfully for NIH funding and forge collaborative ties with investigators statewide with relevant research interests; 3) promote the long-term viability of SC-TRIMH through technology transfer as well as rigorous evaluation and improvement strategies. The Center is led by a multidisciplinary team with expertise in physics, material science, computing, bioengineering, public health, biology, and medicine, thereby coalescing resources and disciplines from Clemson University School of Health Research (CUSHR) and allied with Greenville Health System (GHS). Scientific cores include: 1) Multi-scale Computational Modeling Core to utilize cluster computing, bioinformatics, and systems biology to model patient/specimen specific musculoskeletal system at body, tissue, and cellular levels for the development of novel skeletal devices, interventions, and therapeutics for precision medicine; 2) Advanced Fabrication and Testing Core to generate, refine, and optimize the function and performance of devices, interventions, and therapeutics using the advanced micro and macro fabrication technologies; 3) Preclinical Assessment Core to provide animal testing and human cadaver analysis to assess the in vivo function of novel devices, interventions, and therapeutics. These cores will enable the initial 5 junior investigator projects to implement the new concept of Virtual Human Trials to advance musculoskeletal health and facilitate their competitiveness for national research awards. Extensive institutional support – including flexible funds, new faculty recruitment and major equipment purchase – will underwrite the Center's long-term success and viability. This initiative capitalizes on the existing infrastructure at Clemson University, CUSHR, and its innovation hub at GHS.