SC COBRE for TranslationalResearch Improving MusculoskeletalHealth (SC-TRIMH)

SC COBRE 改善肌肉骨骼健康转化研究 (SC-TRIMH)

• 批准号: 10714162
• 负责人: Hai Yao
• 金额: $ 225.52万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10714162
• 关键词: 3-Dimensional; Adult; Affect; American; Animal Testing; Animals; Area; Artificial Intelligence; Authorization documentation; Award; Big Data; Bioinformatics; Biomedical Engineering; Biomedical Research; Biosensor; Bone Diseases; Cadaver; Cell Nucleus; Centers of Research Excellence; Clinical; Clinical Research; Collaborations; Computer Models; Computing Methodologies; Conceptions; Development; Devices; Discipline; Evaluation; Exposure to; Extramural Activities; Faculty; Foundations; Funding; Generations; Goals; Grant; Growth; Health; Health Resources; Health system; Healthcare; Human; Infrastructure; Institution; International; Intervention; Leadership; Machine Learning; Mentors; Microfabrication; Modeling; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Outcome; Patient Care; Patients; Performance; Persons; Phase; Positioning Attribute; Process; Program Development; Publishing; Recovery; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Role; Schools; Science; Source; South Carolina; Specimen; Speed; Stretching; Systems Biology; Talents; Techniques; Technology; Technology Transfer; Testing; Therapeutic; Time; Tissue Model; Tissues; Translational Research; Translational trial; Translations; United States National Institutes of Health; Universities; Validation; Veterinary Medicine; Wages; Woman; Work; aging population; arthropathies; authority; biomarker development; bioprinting; career development; clinical practice; cluster computing; college; commercialization; cost; cost estimate; digital; disability; experience; fabrication; flexibility; forging; imaging modality; improved; in silico; in vivo; innovation; interest; manufacturing technology; member; multi-scale modeling; multidisciplinary; new technology; novel; novel therapeutics; pre-clinical assessment; programs; randomized, clinical trials; recruit; sensor technology; skills; success; technology platform; tenure track; training opportunity; trend; veterinary science; virtual human

SUMMARY The overall goal of the South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) is to advance our understanding of musculoskeletal diseases and their management by enhancing and expanding the biomedical research capacity at Clemson University. Phase I SC-TRIMH successfully established and implemented the new scientific paradigm of Virtual Human Trials (VTH) for translational research. Virtual Human Trials consists of powerful computational modeling combined with quantitative functional validation and in vivo assessment to expedite the development of new therapeutics, interventions, and devices for musculoskeletal health. The overarching SC-TRIMH Phase II approach is to continue promoting outstanding multidisciplinary and collaborative research to improve patient care using this new paradigm. SC- TRIMH is a multidisciplinary and interactive center promoting translational research for musculoskeletal health which supports junior investigators and enhances their research competitiveness. The specific aims are to: 1) expand the critical mass of funded investigators conducting musculoskeletal research by implementing the concept of VHT for the development of new devices, interventions, and therapeutics for musculoskeletal disorders; 2) strengthen innovative scientific cores that support and advance musculoskeletal research to provide SC-TRIMH researchers with the best support to move their research forward to patient care; and 3) advance the ongoing development of an independent, sustainable, multidisciplinary thematic program by promoting the planning of program project and center grants at the institution level by building teams of PIs in niche areas, establishing a platform for technology transfer and commercialization through collaborations with Clemson University Research Foundation and the South Carolina Research Authority for academic startups, and develop a strategy for administrative infrastructure and financial recovery for SC-TRIMH resources. The Center is led by a leadership team with multidisciplinary expertise coalescing resources and disciplines from Clemson University School of Health Research (CUSHR) and its clinical partner, PRISMA Health System (PHS). The scientific cores include: 1) Multi-scale Computational Modeling Core providing cluster computing, bioengineering, bioinformatics, and systems biology expertise to model patient/specimen specific musculoskeletal system at body, tissue, and cellular levels for the development of novel technology; 2) Advanced Fabrication and Testing Core to generate, refine, and optimize the function and performance of technology using the advanced micro and macro fabrication technologies; and, 3) Preclinical Assessment Core to provide animal testing and human cadaver analysis to assess the in vivo function of novel devices, interventions, and therapeutics. These cores will support Phase II Research Project Leaders (RPLs) to advance musculoskeletal health and facilitate their competitiveness for national research awards. Extensive institutional support including flexible funds and three new tenure-track faculty positions will contribute to the Center's long-term success and viability.

总结 南卡罗来纳州COBRE改善肌肉骨骼健康转化研究的总体目标 （SC-TRIMH）是通过加强我们对肌肉骨骼疾病及其管理的了解， 并扩大了克莱姆森大学的生物医学研究能力。第一阶段SC-TRIMH成功 建立并实施了虚拟人体试验（VTH）的新科学范式， research.虚拟人体试验由强大的计算建模与定量分析相结合组成。 功能验证和体内评估，以加快新疗法、干预措施和 用于肌肉骨骼健康的设备。SC-TRIMH第二阶段的总体方法是继续促进 杰出的多学科和合作研究，以改善病人护理使用这一新的范例。系统控制器- TRIMH是一个多学科和互动中心，促进肌肉骨骼健康的转化研究 支持初级研究人员，提高他们的研究竞争力。具体目标是：1） 通过实施 VHT概念，用于开发肌肉骨骼疾病的新器械、干预和治疗 2）加强支持和推进肌肉骨骼研究的创新科学核心， SC-TRIMH研究人员获得最好的支持，将他们的研究推向患者护理; 3）推进 持续发展一个独立的，可持续的，多学科的主题方案，通过促进 通过在适当领域建立项目研究员团队，在机构一级规划项目和中心赠款， 通过与克莱姆森的合作，建立技术转让和商业化平台 大学研究基金会和南卡罗来纳州研究管理局的学术创业，并开发 为SC-TRIMH资源制定行政基础设施和财政回收战略。该中心由 一个具有多学科专业知识的领导团队，整合了克莱姆森大学的资源和学科 健康研究学院（CHARHR）及其临床合作伙伴PRISMA健康系统（PHS）。科学核心 包括：1）提供集群计算、生物工程、生物信息学 和系统生物学专业知识，在身体，组织和 用于开发新技术的细胞水平; 2）高级制造和测试核心，以产生， 使用先进的微观和宏观制造技术， 技术;以及，3）临床前评估核心，提供动物试验和人类尸体分析， 评估新器械、干预和治疗的体内功能。这些核心将支持第二阶段 研究项目领导者（RPLs），以促进肌肉骨骼健康，并促进他们的竞争力， 国家研究奖。广泛的机构支持，包括灵活的基金和三个新的任期轨道 教师职位将有助于该中心的长期成功和可行性。