SC COBRE for TranslationalResearch Improving MusculoskeletalHealth (SC-TRIMH)

摘要 南卡罗来纳州改善肌肉骨骼健康的翻译研究中心的总体目标 (SC-TRIMH)的目的是通过加强 并扩大克莱姆森大学的生物医学研究能力。第一阶段SC-TRIMH成功 建立并实施了用于翻译的虚拟人试验(VTH)的新科学范式 研究。虚拟人体试验由强大的计算建模和量化相结合组成 功能验证和体内评估，以加快新疗法、干预和 用于肌肉骨骼健康的设备。SC-TRIMH第二阶段的总体方法是继续推动 卓越的多学科和协作研究，使用这一新范式改善患者护理。SC- TRIMH是一个多学科的互动中心，促进肌肉骨骼健康的转化研究 这为初级研究人员提供支持，提高他们的研究竞争力。具体目标是：1) 通过实施以下措施，扩大进行肌肉骨骼研究的资助研究人员的临界数量 VHT的概念，用于开发肌肉骨骼的新设备、干预和治疗 2)加强支持和推进肌肉骨骼研究的创新科学核心，以提供 SC-TRIMH研究人员获得最好的支持，将他们的研究推进到患者护理；以及3)推动 持续发展独立的、可持续的、多学科的专题方案，通过促进 通过在利基领域建立绩效指标团队，在机构层面规划计划项目和中心赠款， 通过与克莱姆森的合作建立技术转移和商业化的平台 大学研究基金会和南卡罗来纳州研究机构为学术初创企业，并开发 一项管理基础设施和回收SC-TRIMH资源的财务战略。该中心由以下人员领导 一个拥有多学科专业知识的领导团队，将克莱姆森大学的资源和学科结合在一起 卫生研究学院(CUSHR)及其临床合作伙伴PRISMA卫生系统(PHS)。科学核心 包括：1)多尺度计算建模核心，提供集群计算、生物工程、生物信息学、 和系统生物学专业知识，在身体、组织和组织中为患者/标本特定的肌肉骨骼系统建模 用于开发新技术的单元级；2)先进的制造和测试核心以生成、 利用先进的微细加工和宏观加工，精炼和优化技术的功能和性能 技术；以及，3)临床前评估核心，提供动物测试和人体身体分析，以 评估新设备、干预和疗法的体内功能。这些核心将支持第二阶段 研究项目负责人(RPL)，以促进肌肉骨骼健康并促进他们在 国家研究奖。广泛的机构支持，包括灵活的资金和三个新的终身教职轨道 教师职位将有助于该中心的长期成功和生存能力。

SUMMARY The overall goal of the South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) is to advance our understanding of musculoskeletal diseases and their management by enhancing and expanding the biomedical research capacity at Clemson University. Phase I SC-TRIMH successfully established and implemented the new scientific paradigm of Virtual Human Trials (VTH) for translational research. Virtual Human Trials consists of powerful computational modeling combined with quantitative functional validation and in vivo assessment to expedite the development of new therapeutics, interventions, and devices for musculoskeletal health. The overarching SC-TRIMH Phase II approach is to continue promoting outstanding multidisciplinary and collaborative research to improve patient care using this new paradigm. SC- TRIMH is a multidisciplinary and interactive center promoting translational research for musculoskeletal health which supports junior investigators and enhances their research competitiveness. The specific aims are to: 1) expand the critical mass of funded investigators conducting musculoskeletal research by implementing the concept of VHT for the development of new devices, interventions, and therapeutics for musculoskeletal disorders; 2) strengthen innovative scientific cores that support and advance musculoskeletal research to provide SC-TRIMH researchers with the best support to move their research forward to patient care; and 3) advance the ongoing development of an independent, sustainable, multidisciplinary thematic program by promoting the planning of program project and center grants at the institution level by building teams of PIs in niche areas, establishing a platform for technology transfer and commercialization through collaborations with Clemson University Research Foundation and the South Carolina Research Authority for academic startups, and develop a strategy for administrative infrastructure and financial recovery for SC-TRIMH resources. The Center is led by a leadership team with multidisciplinary expertise coalescing resources and disciplines from Clemson University School of Health Research (CUSHR) and its clinical partner, PRISMA Health System (PHS). The scientific cores include: 1) Multi-scale Computational Modeling Core providing cluster computing, bioengineering, bioinformatics, and systems biology expertise to model patient/specimen specific musculoskeletal system at body, tissue, and cellular levels for the development of novel technology; 2) Advanced Fabrication and Testing Core to generate, refine, and optimize the function and performance of technology using the advanced micro and macro fabrication technologies; and, 3) Preclinical Assessment Core to provide animal testing and human cadaver analysis to assess the in vivo function of novel devices, interventions, and therapeutics. These cores will support Phase II Research Project Leaders (RPLs) to advance musculoskeletal health and facilitate their competitiveness for national research awards. Extensive institutional support including flexible funds and three new tenure-track faculty positions will contribute to the Center's long-term success and viability.