Administrative Core

总结 该ADMIN核心的使命是负责领导、整合和成功 为南卡罗来纳州转化研究实施COBRE，改善肌肉骨骼健康 （SC-TRIMH）。ADMIN核心主管是姚海博士。Martine LaBerge博士副主任; 温莎谢里尔博士和迈克尔克恩博士执行委员会（EC）4名成员。一个 内部咨询委员会由9名机构高级领导人组成，外部咨询委员会由3-5人组成 杰出的科学家将提供客观的监督，评估和战略互动，以优化该中心的 冲击由7名医生组成的临床咨询委员会将深入了解临床问题， 初级研究员（JI）的研究，加上帮助推进创新，并给予机械的理解， 转化/临床获益。管理核心的目标是：（1）提供有效的领导， （2）通过建立一个严格的 该计划采用“360°风格”评估流程，使导师和学员都受益，（3）启动试点 以SC-TRIMH为主题的项目计划，以吸引新的和/或已建立的调查人员，使他们能够 通过访问科学核心、指导和所有其他方案资源生成初步数据， 获得校外竞争性研究奖的目标，（4）制定和实施一个综合的，长期的， 长期评估计划，形成性和总结性的方法，以评估整体中心及其 零部件该管理核心的创新功能包括：（1）虚拟人体试验（VHT）， 通过（i）计算机模拟，（ii）器械制造的迭代过程， 和/或传感器植入，（iii）与动物或人尸体中的体内评估相结合。(2)利用 工程专业知识，原则和实践的优势，以实现转化生物医学效益。 (3)指导团队：每个联合执行将有一名初级和二级指导员，所有SC-TRIMH成员将 成为加强和帮助这种指导的资源。(4)指导计划：指导计划将培训， 教育和发展导师和学员，使用六西格玛和360°形成性评估 迭代改进的评估方法。(5)技术进步：预计 COBRE以其工程重点和设备制造，应该能够推动边界， 肌肉骨骼设备，特别是与我们的技术转让连接（CUBEInC）。(6)评估计划： SC-TRIMH COBRE的所有组件都将使用六西格玛和360°评估方法来改进 每个方面。(7)临床医生和工程师之间的接口：学科之间的接口是最好的 创新的地方，从而促进不同的专业知识，培训和科学学科之间的互动 这对生物医学的进步有着最大的潜力。

SUMMARY The mission of this ADMIN core is to be responsible for the leadership, integration and successful implementation of the COBRE for South Carolina Translational Research Improving Musculoskeletal Health (SC-TRIMH). The ADMIN Core director is Hai Yao, Ph.D. with Martine LaBerge, Ph.D. as Associate Director; Windsor Sherrill, PhD. and Michael Kern, Ph.D. complete the 4 member Executive Committee (EC). An Internal Advisory Committee of 9 senior institutional leaders and an External Advisory Committee of 3-5 eminent scientists will provide objective oversight, evaluation and strategic interactions to optimize the Center's impact. A Clinical Advisory Committee of 7 physicians will give insight into clinical problems that will focus junior investigator (JI) research, plus help advance innovation and give mechanistic understanding into translational/clinical benefits. The aims of the ADMIN Core are to: (1) Provide effective Leadership and Management to the SC-TRIMH, (2) Enhance Mentoring and Faculty Development by establishing a rigorous program that uses a “360° style” evaluation process to benefit both mentor and mentee, (3) Initiate a Pilot Projects Program with the SC-TRIMH themes to attract new and/or established investigators, enabling them to generate preliminary data via access to scientific cores, mentoring and all other programmatic resources with a goal of obtaining extramural competitive research awards, and (4) Develop and implement an integrated, long- term evaluation plan, with formative and summative methodologies, to assess the overall Center and its component parts. Innovative features of this ADMIN Core include: (1) Virtual Human Trials (VHT), bridging the gap between benchtop and clinics, via the iterative process of (i) computer simulation, (ii) device fabrication and/or sensor implantation, (iii) combined with in vivo assessment in animal or human cadavers. (2) Utilizing the strengths of engineering expertise, principles, and practices to achieve translational biomedical benefits. (3) Mentoring Team: each JI will have a primary and secondary mentor and all the SC-TRIMH members will be a resource to enhance and aid this mentoring. (4) Mentoring program: The mentoring program will train, educate and develop both mentors and mentees, using formative assessment with Six Sigma and 360° evaluation approaches for iterative improvement. (5) Technological advancements: It is anticipated that this COBRE with its engineering focus and device fabrication, should be able to push boundaries in musculoskeletal devices, especially with our technology transfer connection (CUBEInC). (6) Evaluation Plan: All components of the SC-TRIMH COBRE will use Six Sigma and 360° Evaluation approaches to improve every aspect. (7) Interface between clinicians and engineers: The interface between disciplines is the best place for innovations, thus facilitating interactions between diverse expertise, training, and scientific disciplines which has the greatest potential for biomedical advances.