SC COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH)

项目摘要 南卡罗来纳州的COBRE转化研究改善肌肉骨骼健康（SC-TRIMH）旨在 提高和扩大生物医学研究能力在克莱姆森大学，以促进优秀的 骨与关节疾病的多学科、协作和转化研究。作为其组成部分 SC-TRIMH，先进制造和测试（AFT）核心已经建立，作为集中的 三维设计，快速原型和先进的测试资源，为TRIMH研究人员执行他们的 肌肉骨骼转化研究在过去的四年里，AFT核心在微观领域建立了强大的能力， 以及使用通用非生物材料的设备和测试模型的宏观制造和快速原型制作 例如金属、玻璃、陶瓷和聚合物。我们的实验室配备了最先进的激光- 基于增材、减材加工系统，这些系统需要丰富的经验和专业知识， 操作并且具有有限的容量以用于高容量吞吐量。AFL LaserMaster LZM 125+系统是一种 全自动光纤和玻璃加工系统，使用CO2激光热源进行拼接， 玻璃直径从5 µ m到10 µ m的锥形、透镜化、连接、微结构化和其他玻璃成型操作 该玻璃加工系统可以编程以制造光纤微传感器， 用于各种医疗应用的微型器件，包括SC执行的当前和未来研究项目， TRIMH研究人员。具体来说，新系统将允许我们制造1）光纤尖端透镜，2）光纤光栅，3） 光纤锥，4）光纤接头，5）光纤干涉仪，6）光纤束，7）光纤微结构，8）光纤谐振器， 9)光纤螺旋和10）其它新的光纤装置。这些设备是用于验证 由SC-TIRMH投资者研发的肌肉骨骼模型。制造协议将是 由核心人员开发和优化，然后目标教师及其受训人员将接受操作培训 设备的制造。在克莱姆森大学或任何地方都没有这种能力 克莱姆森主校区方圆125英里。增加的设备将使SC-TRIMH调查人员能够 制造新的智能传感器，以改善诊断和治疗患者患有 肌肉骨骼健康疾病。我们要求资金购买全自动光纤和玻璃 处理系统（特别是AFL LaserMaster LZM125+系统），以增强AFT核心和我们的 能够直接制造用于体内和体外分析系统的智能传感器。总造价 二十四万一千七百八十九块七毛五

Project Summary The South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) aims to enhance and expand the Biomedical Research capacity at Clemson University to promote outstanding multidisciplinary, collaborative, and translational research in bone and joint diseases. As an integral part of the SC-TRIMH, the Advanced Fabrication and Testing (AFT) Core has been established as the centralized resources of 3D design, rapid prototyping and advanced testing for the TRIMH investigators to perform their translational musculoskeletal research. In the past four years, the AFT core has built strong capacities in micro and macro fabrication and rapid prototyping of devices and test models using general-purpose, non-biomaterials such as metal, glass, ceramics, and polymers. While our laboratories are outfitted with state-of-the-art laser- based additive, subtractive machining systems, these systems require significant experience and expertise to operate and have a limited capacity for high volume throughput. The AFL LaserMaster LZM125+ system is a fully automated optical fiber and glass processing system that uses a CO2 laser heat source to perform splicing, tapering, lensing, joining, micro-structuring, and other glass shaping operations with glass diameters from 5µm to 2.0 mm. This glass processing system can be programed to fabricate optical fiber microsensors and microdevices for various medical applications including current and future research projects performed by SC- TRIMH researchers. Specifically, the new system will allow us to fabricate 1) fiber tip lenses, 2) fiber gratings, 3) fiber tapers, 4) fiber joints, 5) fiber interferometers, 6) fiber bundles, 7) fiber microstructures, 8) fiber resonators, 9) fiber spirals, and 10) other new fiber devices. These devices make perfect sensors for validating the musculoskeletal models researched and developed by the SC-TIRMH investors. Fabrication protocols will be developed and optimized by Core personnel, then targeted faculty and their trainees will be trained to operate the manufacturing of the devices. There is no such capability available at Clemson University or anywhere within 125 miles radius of Clemson main campus. The added equipment will allow the SC-TRIMH investigators to fabricate new smart sensors to improve diagnosis and therapeutic treatment in patients suffering from musculoskeletal health disease. We request funding to purchase a fully automated optical fiber and glass processing system (specifically an AFL LaserMaster LZM125+ system) to enhance the AFT Core and our capability to directly fabricate smart sensors for in vivo and in vitro analysis systems. The total cost is $241,789.75.