SC COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH)

项目摘要 南卡罗来纳州改善肌肉骨骼健康翻译研究中心(SC-TRIMH)旨在 加强和扩大克莱姆森大学的生物医学研究能力，促进卓越 骨和关节疾病的多学科、协作和转化性研究。作为该计划的组成部分 SC-TRIMH，先进制造和测试(AFT)核心已被建立为集中式 为TRIMH调查人员提供3D设计、快速原型制作和高级测试的资源 翻译肌肉骨骼研究。在过去的四年里，AFT的核心在微观方面建立了强大的能力 以及使用通用、非生物材料的设备和测试模型的宏观制造和快速原型制作 例如金属、玻璃、陶瓷和聚合物。虽然我们的实验室配备了最先进的激光- 基于加法、减法加工系统，这些系统需要丰富的经验和专业知识 操作并具有有限的容量，以实现高容量吞吐量。AFL LaserMaster LZM125系统是 使用CO2激光热源进行拼接的全自动光纤和玻璃加工系统， 玻璃直径为5微米的锥形、透镜、连接、微结构和其他玻璃成型操作 至2.0毫米。该玻璃加工系统可编程制造光纤微传感器和 用于各种医疗应用的微型设备，包括SC- TRIMH的研究人员。具体地说，新系统将允许我们制造1)光纤尖端透镜，2)光纤光栅，3) 光纤锥形，4)光纤接头，5)光纤干涉仪，6)光纤束，7)光纤微结构，8)光纤谐振器， 9)光纤螺旋线，以及其他新的光纤设备。这些设备是验证 由SC-TIRMH投资者研发的肌肉骨骼模型。制造协议将是 由核心人员开发和优化，然后对目标教师及其受训人员进行操作培训 这些设备的制造。克莱姆森大学或任何地方都没有这样的能力 克莱姆森主校区方圆125英里。增加的设备将使SC-TRIMH调查人员能够 制造新的智能传感器以改善患者的诊断和治疗 肌肉骨骼健康疾病。我们请求资金购买全自动光纤和玻璃 处理系统(特别是AFL LaserMaster LZM125系统)，以增强AFT核心和我们的 能够直接制造用于体内和体外分析系统的智能传感器。总成本是 241,789.75美元。

Project Summary The South Carolina COBRE for Translational Research Improving Musculoskeletal Health (SC-TRIMH) aims to enhance and expand the Biomedical Research capacity at Clemson University to promote outstanding multidisciplinary, collaborative, and translational research in bone and joint diseases. As an integral part of the SC-TRIMH, the Advanced Fabrication and Testing (AFT) Core has been established as the centralized resources of 3D design, rapid prototyping and advanced testing for the TRIMH investigators to perform their translational musculoskeletal research. In the past four years, the AFT core has built strong capacities in micro and macro fabrication and rapid prototyping of devices and test models using general-purpose, non-biomaterials such as metal, glass, ceramics, and polymers. While our laboratories are outfitted with state-of-the-art laser- based additive, subtractive machining systems, these systems require significant experience and expertise to operate and have a limited capacity for high volume throughput. The AFL LaserMaster LZM125+ system is a fully automated optical fiber and glass processing system that uses a CO2 laser heat source to perform splicing, tapering, lensing, joining, micro-structuring, and other glass shaping operations with glass diameters from 5µm to 2.0 mm. This glass processing system can be programed to fabricate optical fiber microsensors and microdevices for various medical applications including current and future research projects performed by SC- TRIMH researchers. Specifically, the new system will allow us to fabricate 1) fiber tip lenses, 2) fiber gratings, 3) fiber tapers, 4) fiber joints, 5) fiber interferometers, 6) fiber bundles, 7) fiber microstructures, 8) fiber resonators, 9) fiber spirals, and 10) other new fiber devices. These devices make perfect sensors for validating the musculoskeletal models researched and developed by the SC-TIRMH investors. Fabrication protocols will be developed and optimized by Core personnel, then targeted faculty and their trainees will be trained to operate the manufacturing of the devices. There is no such capability available at Clemson University or anywhere within 125 miles radius of Clemson main campus. The added equipment will allow the SC-TRIMH investigators to fabricate new smart sensors to improve diagnosis and therapeutic treatment in patients suffering from musculoskeletal health disease. We request funding to purchase a fully automated optical fiber and glass processing system (specifically an AFL LaserMaster LZM125+ system) to enhance the AFT Core and our capability to directly fabricate smart sensors for in vivo and in vitro analysis systems. The total cost is $241,789.75.