Noninvasive modulation of perception and cognition with flicker induced response modulation.

通过闪烁引起的响应调制对感知和认知进行无创调制。

• 批准号: 10398962
• 负责人: Bart Krekelberg
• 金额: $ 38.07万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398962
• 关键词: Amblyopia; Area; Attention; Behavioral; Brain; Chemosensitization; Cognition; Cognitive deficits; Computer Models; Contrast Sensitivity; Data; Detection; Elderly; Electroencephalography; Frequencies; Goals; Health; Hour; Human; Human Volunteers; Laboratories; Lead; Methods; Modeling; Neurons; Occipital lobe; Parietal; Patients; Pattern; Perception; Performance; Photic Stimulation; Research; Rodent; Short-Term Memory; Specificity; Techniques; Testing; Therapeutic Uses; V1 neuron; Vision; Visual; Visual Acuity; Visual Cortex; Visual impairment; Visuospatial; base; clinically relevant; density; experimental study; extracellular; human subject; improved; insight; luminance; neuropsychiatric disorder; neuropsychiatry; neuroregulation; nonhuman primate; recruit; recurrent neural network; relating to nervous system; response; spatial integration; tool; visual cognition; visual process; visual processing; visual stimulus

Project Summary This project investigates the use of repetitive visual stimulation as a tool to improve visual cognition. Surprisingly, the repeated presentation of simple visual patterns can result in long-term plasticity, reflected in increased neural responses, but also in behavioral improvements that last for hours, even days. In current approaches using RVS, however, these improvements are limited to the specific, repeated patterns; this limits the practical usefulness of RVS. The proposed project builds on recent findings in the nonhuman primate demonstrating widespread and general increases in neural responses after the repeated presentation of a uniform grey screen with sinusoidally modulated luminance. The first aim is to show, using EEG, that such long-lasting increases in neural responses also occur in the human brain. The second aim is to determine which aspects of visual cognition are improved by this boost in neural responses. The project will assess improvements in low-level vision such as detection and visual acuity, but also higher-level visual processes such as visuospatial attention, and visual working memory. The pilot data already show widespread neural changes in the human brain and substantial behavioral improvements in, for instance, visual acuity. A successful tool to improve visual cognition would have a significant impact, as it could be used therapeutically in low vision conditions (e.g., amblyopia), but also in the elderly or healthy human subjects, to deliver a boost in performance.

项目总结