Noninvasive modulation of perception and cognition with flicker induced response modulation.

项目摘要 这个项目调查了重复视觉刺激作为改善视觉认知的工具的使用。令人惊讶的是， 重复呈现简单的视觉模式可以导致长期的可塑性，这反映在神经功能的增加上 反应，但在持续数小时甚至数天的行为改善方面也是如此。在使用RVS的当前方法中， 然而，这些改进仅限于特定的、重复的模式；这限制了实际用途 RVS。拟议的项目建立在非人类灵长类动物的最新发现基础上，表明了广泛的和 重复呈现正弦分布的均匀灰屏后神经反应的普遍增加 调制亮度。第一个目标是用脑电波显示，神经反应的这种持久的增加 也存在于人脑中。第二个目标是确定视觉认知的哪些方面得到了改善 通过这种神经反应的增强。该项目将评估低水平视觉方面的改进，如检测 和视觉敏锐度，以及更高级别的视觉过程，如视觉空间注意和视觉工作 记忆。试点数据已经显示了人脑中广泛的神经变化和实质性的行为 例如，在视觉敏锐度方面的改善。一个成功的改善视觉认知的工具将具有重要的 影响，因为它可用于治疗低视力状况(例如弱视)，但也可用于老年人或 健康的人体受试者，以提供性能提升。

Project Summary This project investigates the use of repetitive visual stimulation as a tool to improve visual cognition. Surprisingly, the repeated presentation of simple visual patterns can result in long-term plasticity, reflected in increased neural responses, but also in behavioral improvements that last for hours, even days. In current approaches using RVS, however, these improvements are limited to the specific, repeated patterns; this limits the practical usefulness of RVS. The proposed project builds on recent findings in the nonhuman primate demonstrating widespread and general increases in neural responses after the repeated presentation of a uniform grey screen with sinusoidally modulated luminance. The first aim is to show, using EEG, that such long-lasting increases in neural responses also occur in the human brain. The second aim is to determine which aspects of visual cognition are improved by this boost in neural responses. The project will assess improvements in low-level vision such as detection and visual acuity, but also higher-level visual processes such as visuospatial attention, and visual working memory. The pilot data already show widespread neural changes in the human brain and substantial behavioral improvements in, for instance, visual acuity. A successful tool to improve visual cognition would have a significant impact, as it could be used therapeutically in low vision conditions (e.g., amblyopia), but also in the elderly or healthy human subjects, to deliver a boost in performance.