Noninvasive modulation of perception and cognition with flicker induced response modulation.

通过闪烁引起的响应调制对感知和认知进行无创调制。

• 批准号: 10617694
• 负责人: Bart Krekelberg
• 金额: $ 39.25万
• 依托单位: RUTGERS THE STATE UNIV OF NJ NEWARK
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617694
• 关键词: Amblyopia; Area; Attention; Behavioral; Brain; Chemosensitization; Cognition; Cognitive deficits; Computer Models; Contrast Sensitivity; Data; Detection; Elderly; Electroencephalography; Frequencies; Goals; Health; Hour; Human; Human Volunteers; Laboratories; Methods; Modeling; Neural Network Simulation; Neurons; Occipital lobe; Parietal; Patients; Pattern; Perception; Performance; Photic Stimulation; Research; Rodent; Short-Term Memory; Specificity; Techniques; Testing; Therapeutic Uses; V1 neuron; Vision; Visual; Visual Acuity; Visual Cortex; Visual impairment; Visuospatial; clinically relevant; density; experimental study; extracellular; human subject; improved; insight; luminance; neural; neuropsychiatric disorder; neuropsychiatry; neuroregulation; nonhuman primate; recruit; recurrent neural network; response; spatial integration; tool; visual cognition; visual process; visual processing; visual stimulus

Project Summary This project investigates the use of repetitive visual stimulation as a tool to improve visual cognition. Surprisingly, the repeated presentation of simple visual patterns can result in long-term plasticity, reflected in increased neural responses, but also in behavioral improvements that last for hours, even days. In current approaches using RVS, however, these improvements are limited to the specific, repeated patterns; this limits the practical usefulness of RVS. The proposed project builds on recent findings in the nonhuman primate demonstrating widespread and general increases in neural responses after the repeated presentation of a uniform grey screen with sinusoidally modulated luminance. The first aim is to show, using EEG, that such long-lasting increases in neural responses also occur in the human brain. The second aim is to determine which aspects of visual cognition are improved by this boost in neural responses. The project will assess improvements in low-level vision such as detection and visual acuity, but also higher-level visual processes such as visuospatial attention, and visual working memory. The pilot data already show widespread neural changes in the human brain and substantial behavioral improvements in, for instance, visual acuity. A successful tool to improve visual cognition would have a significant impact, as it could be used therapeutically in low vision conditions (e.g., amblyopia), but also in the elderly or healthy human subjects, to deliver a boost in performance.

项目摘要 本项目研究使用重复视觉刺激作为改善视觉认知的工具。令人惊奇的是， 重复呈现简单的视觉模式可以导致长期的可塑性，反映在增加的神经 反应，但也在持续数小时，甚至数天的行为改善。在使用RVS的当前方法中， 然而，这些改进仅限于特定的、重复的模式;这限制了其实际用途 的RVS。拟议的项目建立在最近在非人类灵长类动物中的发现的基础上， 在重复呈现具有正弦曲线的均匀灰色屏幕后，神经反应的普遍增加 调制亮度第一个目的是用脑电图来证明，这种神经反应的长期增加， 也发生在人脑中。第二个目的是确定视觉认知的哪些方面得到了改善 神经反应的增强。该项目将评估低水平视力的改善，如检测 和视觉敏锐度，但也有更高层次的视觉过程，如视觉空间注意，和视觉工作 记忆试验数据已经显示了人类大脑中广泛的神经变化和大量的行为变化。 例如，视力的改善。一个成功的工具，以提高视觉认知将有显着的 影响，因为它可以在治疗上用于低视力状况（例如，弱视），但也在老年人或 健康的人类受试者，以提高表现。