National Pediatric Rehabilitation Resource Center

项目总结(总体) 我们建议建立一个国家儿科康复资源中心(PedRehab Ctr)来提供研究 基础设施支持，以提高研究人员进行严格临床试验的能力，以测试和实施 儿科医疗康复中的循证干预。我们的具体目标是：1)提供积极的 课程、研讨会、网络研讨会和演示的存档计划，涉及设计、实施、 分析和报告高质量、高影响的临床试验-包括复杂、多组分和 多阶段治疗(教学互动)；2)支持跨学科研究合作，促进 在进行多地点临床试验方面的创新和卓越(指导合作机会)；3) 在测量和理解神经生物学机制方面开发急需的技术 儿科医疗康复中的生物行为结果(技术开发)；4)通过以下方式资助先导研究 与领先的国家组织建立伙伴关系，为美国国立卫生研究院的竞争性申请提供数据 儿科医疗康复(试点研究)；以及5)通过广告和宣传促进儿科康复中心的专业知识 与主要协会协调，编写急需的跨学科综合参考 手册(在线和动态更新)解决儿科医疗康复研究中固有的问题 (促进中心专业知识)。我们对儿科康复中的关键差距、障碍和机会的分析 研究为我们提出的实现这些目标的战略提供了信息。 PedRehab Ctr的行政组织和业务计划将实现效率、杠杆 资源，并通过与领先组织、研究网络和 特殊利益集团。PedRehab Ctr将召集一个由患者/家长代表组成的全国咨询小组 协助PedRehab CTR活动的计划和评估。PedRehab Ctr提出增加 儿科康复劳动力和研究的多样性。我们弗吉尼亚理工大学的PedRehab Ctr核心团队， 俄亥俄州立大学和全国儿童医院拥有深厚的专业知识和独特的实验室，支持 发展科学，神经成像，儿童神经学，职业治疗，物理治疗，医学 康复科学、生物工程、研究设计与法规、实施科学。儿童康复中心 CTR活动将建立在我们在NIH多点随机对照试验(第二阶段和第三阶段)中的领导作用的基础上，我们的 临床和翻译科学奖(CTSA)，NIH研究网络，NIH培训计划 转译生物医学和实施科学，以及国家组织。总体而言，PedRehab Ctr拥有 增加科学严谨、高效和高影响的临床试验数量的潜力 儿科医疗康复。反过来，科学发现的扩展和有效实施 这些试验可能会在功能结果、健康和 受儿童期发病障碍和残疾影响的个人的生产力。

Project Summary (Overall) We propose a National Pediatric Rehabilitation Resource Center (PedRehab Ctr) to offer research infrastructure supports to improve investigators' capacity to conduct rigorous clinical trials to test and implement evidence-based interventions in pediatric medical rehabilitation. Our specific aims are: 1) to provide an active and archived program of courses, workshops, webinars, and demonstrations related to the design, conduct, analysis, and reporting of high-quality, high-impact clinical trials - including complex, multicomponent, and multiphase treatments (Didactic Interactions); 2) to support interdisciplinary research collaborations that promote innovation and excellence in conducting multi-site clinical trials (Mentored Collaborative Opportunities); 3) to develop critically needed techniques in measurement and understanding of neurobiological mechanisms and biobehavioral outcomes in pediatric medical rehabilitation (Techniques Development); 4) to fund pilot studies via partnerships with leading national organizations to yield data for informing competitive NIH applications in pediatric medical rehabilitation (Pilot Studies); and 5) to promote PedRehab Ctr expertise by advertising and coordinating with major associations and to prepare a much-needed comprehensive, interdisciplinary reference manual (online and dynamically updated) addressing issues inherent in pediatric medical rehabilitation research (Promoting Center Expertise). Our analysis of critical gaps, obstacles, and opportunities in pediatric rehabilitation research informs the strategies we propose to achieve these aims. The administrative organization and operational plan for PedRehab Ctr will realize efficiencies, leverage resources, and ensure broad outreach through partnerships with leading organizations, research networks, and special interest groups. PedRehab Ctr will convene a National Advisory Group with patient/parent representation to assist in plans for and evaluation of PedRehab Ctr activities. PedRehab Ctr proposes approaches to increase diversity in the pediatric rehabilitation workforce and research. Our PedRehab Ctr core team at Virginia Tech, The Ohio State University, and Nationwide Children's Hospital has deep expertise and unique labs that support developmental science, neuroimaging, pediatric neurology, occupational therapy, physical therapy, medical rehabilitation science, bioengineering, research design and regulations, and Implementation Science. PedRehab Ctr activities will build on our leadership roles in NIH multisite randomized controlled trials (Phase II and III), our Clinical and Translational Science Awards (CTSAs), NIH research networks, NIH training programs in translational biomedical and implementation science, and national organizations. Collectively, PedRehab Ctr has the potential to increase the number of scientifically rigorous, productive, and high-impact clinical trials in pediatric medical rehabilitation. In turn, the expansion and effective implementation of scientific findings from these trials will likely produce widespread and enduring improvements in functional outcomes, health, and productivity of individuals affected by childhood-onset disorders and disabilities.