National Pediatric Rehabilitation Resource Center

项目概要（总体） 我们建议建立一个国家儿科康复资源中心（PedRehab Ctr）， 基础设施支持，以提高研究人员进行严格临床试验的能力， 儿科医学康复中的循证干预。我们的具体目标是：1）提供一个积极的 和存档的课程，研讨会，网络研讨会，并与设计，行为， 分析和报告高质量、高影响力的临床试验-包括复杂的、多组分的和 多阶段治疗（教学互动）; 2）支持跨学科研究合作，促进 创新和卓越的多中心临床试验（指导合作机会）; 3） 发展急需的测量和理解神经生物学机制的技术， 儿科医学康复的生物行为结果（技术开发）; 4）通过 与领先的国家组织建立伙伴关系，以产生数据，为竞争性NIH应用提供信息， 儿科医疗康复（试点研究）;和5）通过广告和 与主要协会协调，并准备一个急需的全面的，跨学科的参考 手册（在线和动态更新）解决儿科医疗康复研究中固有的问题 （促进中心的专业知识）。我们对儿科康复中的关键差距、障碍和机遇的分析 我们为实现这些目标而提出的战略是通过研究得出的。 PedRehab Ctr的行政组织和运营计划将实现效率， 资源，并通过与领先组织、研究网络和 特殊利益集团。PedRehab Ctr将召集一个由患者/家长代表组成的国家咨询小组 协助PedRehab Ctr活动的计划和评估。PedRehab Ctr提出了增加 儿科康复工作人员和研究的多样性。我们在弗吉尼亚理工大学的PedRehab中心核心团队， 俄亥俄州州立大学和全国儿童医院拥有深厚的专业知识和独特的实验室， 发育科学、神经影像学、小儿神经病学、职业治疗、物理治疗、医学 康复科学，生物工程，研究设计和法规，以及实施科学。PedRehab Ctr活动将建立在我们在NIH多中心随机对照试验（II期和III期）中的领导作用的基础上， 临床和转化科学奖（CTSA），NIH研究网络，NIH培训计划， 转化生物医学和实施科学以及国家组织。总的来说，PedRehab Ctr 有可能增加科学上严格、富有成效和高影响力的临床试验的数量， 儿科医疗康复反过来，扩大和有效实施科学发现， 这些试验可能会在功能结局、健康和 受儿童期发病的疾病和残疾影响的个人的生产力。

Project Summary (Overall) We propose a National Pediatric Rehabilitation Resource Center (PedRehab Ctr) to offer research infrastructure supports to improve investigators' capacity to conduct rigorous clinical trials to test and implement evidence-based interventions in pediatric medical rehabilitation. Our specific aims are: 1) to provide an active and archived program of courses, workshops, webinars, and demonstrations related to the design, conduct, analysis, and reporting of high-quality, high-impact clinical trials - including complex, multicomponent, and multiphase treatments (Didactic Interactions); 2) to support interdisciplinary research collaborations that promote innovation and excellence in conducting multi-site clinical trials (Mentored Collaborative Opportunities); 3) to develop critically needed techniques in measurement and understanding of neurobiological mechanisms and biobehavioral outcomes in pediatric medical rehabilitation (Techniques Development); 4) to fund pilot studies via partnerships with leading national organizations to yield data for informing competitive NIH applications in pediatric medical rehabilitation (Pilot Studies); and 5) to promote PedRehab Ctr expertise by advertising and coordinating with major associations and to prepare a much-needed comprehensive, interdisciplinary reference manual (online and dynamically updated) addressing issues inherent in pediatric medical rehabilitation research (Promoting Center Expertise). Our analysis of critical gaps, obstacles, and opportunities in pediatric rehabilitation research informs the strategies we propose to achieve these aims. The administrative organization and operational plan for PedRehab Ctr will realize efficiencies, leverage resources, and ensure broad outreach through partnerships with leading organizations, research networks, and special interest groups. PedRehab Ctr will convene a National Advisory Group with patient/parent representation to assist in plans for and evaluation of PedRehab Ctr activities. PedRehab Ctr proposes approaches to increase diversity in the pediatric rehabilitation workforce and research. Our PedRehab Ctr core team at Virginia Tech, The Ohio State University, and Nationwide Children's Hospital has deep expertise and unique labs that support developmental science, neuroimaging, pediatric neurology, occupational therapy, physical therapy, medical rehabilitation science, bioengineering, research design and regulations, and Implementation Science. PedRehab Ctr activities will build on our leadership roles in NIH multisite randomized controlled trials (Phase II and III), our Clinical and Translational Science Awards (CTSAs), NIH research networks, NIH training programs in translational biomedical and implementation science, and national organizations. Collectively, PedRehab Ctr has the potential to increase the number of scientifically rigorous, productive, and high-impact clinical trials in pediatric medical rehabilitation. In turn, the expansion and effective implementation of scientific findings from these trials will likely produce widespread and enduring improvements in functional outcomes, health, and productivity of individuals affected by childhood-onset disorders and disabilities.