NRSA Training Core

NRSA 培训核心

• 批准号: 10400208
• 负责人: Darrell N. Kotton
• 金额: $ 47.87万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-13 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10400208
• 关键词: Administrator; Area; Biomedical Engineering; Biomedical Research; Boston; Clinical; Cohort Studies; Competence; Complex; Congresses; Critical Thinking; Development; Discipline; Disease model; Ethics; Face; Faculty; Familiarity; Genes; Goals; Home; Human; In Vitro; Institution; Mentors; Mission; National Research Service Awards; Oral; Organoids; Patients; Pluripotent Stem Cells; Postdoctoral Fellow; Protocols documentation; Regenerative Medicine; Research; Resources; Risk; Science; Scientist; Student recruitment; TNFSF15 gene; Training; Training Programs; Translational Research; Universities; Writing; bench to bedside; cell repository; clinical practice; clinical translation; education research; experience; innovation; novel; open source; patient population; pre-doctoral; precision medicine; programs; regenerative; stem cell biology; stem cells

The objective of this proposal is to provide rigorous training in all aspects of translational research related to regenerative medicine. There is a bourgeoning need for creative, critical, and responsible transdisciplinary scientists as thought leaders and administrators who will spearhead national efforts to bring regenerative medicine into widespread clinical practice. This national need was demonstrated by Congress's 21st Century Cures Act that established regenerative medicine as one of four national research areas in desperate need of clinical translation. This proposal integrates Boston University's marquee programs in biomedical engineering, pluripotent stem cell biology, human organoid in vitro disease modeling, precision medicine, gene editing, stem cell banking, and computational biomedicine to produce an extraordinarily rigorous and comprehensive training program in the emerging, futuristic discipline known broadly as “regenerative medicine.” This proposed renewal of the already successful Regenerative Training Program (RMTP), now in its 4th year, is geared to expanding and maturing this nascent program into a clinically-focused training experience for 6 pre-doctoral and 2 post- doctoral trainees. The proposed RMTP renewal incorporates mentored cross-disciplinary research, exciting courses taught by the leaders of these marquee programs, and additional training in critical thinking, scientific writing, oral presenting, and familiarity with the complex ethics that will face tomorrow's national thought leaders as regenerative medicine research moves from bench to bedside. To prepare for tomorrow's challenges and augment diversity in the research workforce, this renewal includes an innovative, novel year-long Post- baccalaureate Research Education Program (PREP) that recruits students from backgrounds that are traditionally underrepresented in biomedical research. An additional, novel goal of this TL1 is to pioneer the development of regenerative medicine core competencies for the CTSA. These competencies will maintain rigor of training and equip scholars to become leaders in translational regenerative medicine research. Beyond training superb scholars, the many deliverables of this renewed RMTP will include shareable patient-specific stem cell repositories procured from at risk patient populations as well as from the entire Framingham Study cohort, sophisticated protocols that will allow any CTSA institution to prepare patient-derived organoids in vitro, and hands-on training courses or on line modules that will disseminate this expertise freely across the entire CTSA. This “open-source” approach to science is central to the mission of BU's Center for Regenerative Medicine, the physical home of many TL1 faculty, labs and resources.

该提案的目的是在与转化研究相关的各个方面提供严格的培训 再生医学。对创造性、批判性和负责任的跨学科人才的需求日益增长 科学家作为思想领袖和管理者，将带头推动国家努力实现再生 医学进入广泛的临床实践。国会的 21 世纪计划证明了这一国家需求 《治愈法案》将再生医学确立为急需的四个国家研究领域之一 临床翻译。该提案整合了波士顿大学在生物医学工程方面的特色项目， 多能干细胞生物学、人体类器官体外疾病模型、精准医学、基因编辑、干细胞 细胞库和计算生物医学提供极其严格和全面的培训 新兴的未来学科的项目被广泛称为“再生医学”。此次提议的续订 已经成功的再生训练计划 (RMTP) 现已进入第四个年头，旨在扩大 并将这一新生项目完善为 6 名博士前和 2 名博士后的以临床为重点的培训经验 博士生。拟议的 RMTP 更新纳入了受指导的跨学科研究，令人兴奋 由这些大项目的领导者教授的课程，以及批判性思维、科学和其他方面的额外培训 写作、口头演讲以及熟悉未来国家思想领袖将面临的复杂道德规范 随着再生医学研究从实验室转向临床。为明天的挑战做好准备 为了增强研究队伍的多样性，这一更新包括一个创新的、新颖的为期一年的后 学士学位研究教育计划（PREP），招收来自以下背景的学生 传统上在生物医学研究中代表性不足。该 TL1 的另一个新颖目标是开创 为 CTSA 开发再生医学核心能力。这些能力将保持严谨 培训和装备学者成为转化再生医学研究的领导者。超过 培训优秀的学者，这个更新的 RMTP 的许多成果将包括可共享的患者特定 从高危患者群体以及整个弗雷明汉研究中采购的干细胞储存库 队列、复杂的方案将允许任何 CTSA 机构在体外制备患者来源的类器官， 以及实践培训课程或在线模块，这些课程将在整个系统中自由传播这些专业知识 CTSA。这种“开源”科学方法是波士顿大学再生中心使命的核心 医学是许多 TL1 教员、实验室和资源的实际所在地。