NRSA Training Core

这项提议的目标是在翻译研究的所有方面提供严格的培训 再生医学。对创造性、批判性和负责任的跨学科的需求迅速增长 作为思想领袖和管理者的科学家将带头为国家带来再生能源 医学进入了广泛的临床实践。国会的《21世纪英文报》证明了这一国家需求 《治疗法案》将再生医学确立为迫切需要的四个国家研究领域之一 临床翻译。这项提案整合了波士顿大学在生物医学工程方面的主要项目， 多能干细胞生物学，人体器官体外疾病建模，精确医学，基因编辑，干细胞 细胞库和计算生物医学产生了非常严格和全面的培训 这一新兴的、未来主义的学科被广泛称为“再生医学”。这项建议的续期 已经取得成功的再生培训计划(RMTP)现已进入第4个年头，正准备扩大 并将这一新项目成熟为6名博士后和2名博士后的临床培训体验 博士生。建议的RMTP续订结合了有指导的跨学科研究，令人兴奋 由这些大型项目的领导人教授的课程，以及批判性思维的额外培训，科学 写作、口头陈述，以及熟悉明天的国家思想领袖将面临的复杂伦理 随着再生医学研究从板凳转移到床边。为明天的挑战做好准备 增加研究队伍的多样性，这次续订包括一个创新的、新颖的、为期一年的帖子- 文凭研究教育计划(PREP)招收来自以下背景的学生 传统上在生物医学研究中的代表性不足。这个TL1的另一个新目标是开创 为CTSA开发再生医学核心能力。这些能力将保持严谨 培训和装备学者，使其成为转化再生医学研究的领导者。超越 培训优秀的学者，这一更新的RMTP的许多交付内容将包括可共享的特定患者 从高危患者人群以及整个Framingham研究获得的干细胞库 队列，复杂的方案，将允许任何CTSA机构在体外制备患者衍生的有机化合物， 以及实践培训课程或在线模块，这些模块将在整个 CTSA。这种“开源”的科学方法是北卡罗来纳大学再生中心的核心任务 医学，许多TL1教员、实验室和资源的物质家园。

The objective of this proposal is to provide rigorous training in all aspects of translational research related to regenerative medicine. There is a bourgeoning need for creative, critical, and responsible transdisciplinary scientists as thought leaders and administrators who will spearhead national efforts to bring regenerative medicine into widespread clinical practice. This national need was demonstrated by Congress's 21st Century Cures Act that established regenerative medicine as one of four national research areas in desperate need of clinical translation. This proposal integrates Boston University's marquee programs in biomedical engineering, pluripotent stem cell biology, human organoid in vitro disease modeling, precision medicine, gene editing, stem cell banking, and computational biomedicine to produce an extraordinarily rigorous and comprehensive training program in the emerging, futuristic discipline known broadly as “regenerative medicine.” This proposed renewal of the already successful Regenerative Training Program (RMTP), now in its 4th year, is geared to expanding and maturing this nascent program into a clinically-focused training experience for 6 pre-doctoral and 2 post- doctoral trainees. The proposed RMTP renewal incorporates mentored cross-disciplinary research, exciting courses taught by the leaders of these marquee programs, and additional training in critical thinking, scientific writing, oral presenting, and familiarity with the complex ethics that will face tomorrow's national thought leaders as regenerative medicine research moves from bench to bedside. To prepare for tomorrow's challenges and augment diversity in the research workforce, this renewal includes an innovative, novel year-long Post- baccalaureate Research Education Program (PREP) that recruits students from backgrounds that are traditionally underrepresented in biomedical research. An additional, novel goal of this TL1 is to pioneer the development of regenerative medicine core competencies for the CTSA. These competencies will maintain rigor of training and equip scholars to become leaders in translational regenerative medicine research. Beyond training superb scholars, the many deliverables of this renewed RMTP will include shareable patient-specific stem cell repositories procured from at risk patient populations as well as from the entire Framingham Study cohort, sophisticated protocols that will allow any CTSA institution to prepare patient-derived organoids in vitro, and hands-on training courses or on line modules that will disseminate this expertise freely across the entire CTSA. This “open-source” approach to science is central to the mission of BU's Center for Regenerative Medicine, the physical home of many TL1 faculty, labs and resources.