NRSA Training Core

该提案的目的是在与以下方面相关的翻译研究的各个方面提供严格的培训 再生医学有一个新兴的需要创造性的，关键的，负责任的跨学科 科学家作为思想领袖和管理者，他们将带领国家努力， 医学进入广泛的临床实践。国会的《21世纪世纪》证明了这种国家需要 该法案将再生医学确定为迫切需要的四个国家研究领域之一。 临床翻译该提案整合了波士顿大学在生物医学工程方面的大型项目， 多能干细胞生物学，人类类器官体外疾病建模，精准医学，基因编辑，干细胞 细胞库和计算生物医学，以产生一个非常严格和全面的培训 该计划在新兴的，未来的学科被广泛称为“再生医学”。这一提议的更新 已经成功的再生训练计划（RMTP），现在在其第四年，是面向扩大 并使这一新生项目成熟为6名博士前和2名博士后的临床培训经验， 博士生拟议的RMTP更新包含了指导性的跨学科研究，令人兴奋 课程由这些大帐篷节目的领导人讲授，并在批判性思维，科学的额外培训， 写作，口头报告，以及对未来国家思想领袖将面临的复杂道德规范的熟悉 随着再生医学研究从实验室走向临床为明天的挑战做准备， 增加研究人员的多样性，这次更新包括一个创新的，新颖的为期一年的职位， 学士学位研究教育计划（PREP），招收来自以下背景的学生： 传统上在生物医学研究中代表性不足。这个TL 1的另一个新目标是开创 CTSA再生医学核心竞争力的发展。这些能力将保持严谨性 培训和装备学者成为转化再生医学研究的领导者。超出 培训一流的学者，这一更新的RMTP的许多可交付成果将包括可共享的患者特异性 从高危患者群体以及整个Fracket研究中获得的干细胞库 队列，复杂的协议，将允许任何CTSA机构在体外制备患者源性类器官， 和实践培训课程或在线模块，将免费传播这种专门知识， CTSA这种"开源"的科学方法是BU再生中心使命的核心， 医学，许多TL1教师，实验室和资源的物理家园。

The objective of this proposal is to provide rigorous training in all aspects of translational research related to regenerative medicine. There is a bourgeoning need for creative, critical, and responsible transdisciplinary scientists as thought leaders and administrators who will spearhead national efforts to bring regenerative medicine into widespread clinical practice. This national need was demonstrated by Congress's 21st Century Cures Act that established regenerative medicine as one of four national research areas in desperate need of clinical translation. This proposal integrates Boston University's marquee programs in biomedical engineering, pluripotent stem cell biology, human organoid in vitro disease modeling, precision medicine, gene editing, stem cell banking, and computational biomedicine to produce an extraordinarily rigorous and comprehensive training program in the emerging, futuristic discipline known broadly as “regenerative medicine.” This proposed renewal of the already successful Regenerative Training Program (RMTP), now in its 4th year, is geared to expanding and maturing this nascent program into a clinically-focused training experience for 6 pre-doctoral and 2 post- doctoral trainees. The proposed RMTP renewal incorporates mentored cross-disciplinary research, exciting courses taught by the leaders of these marquee programs, and additional training in critical thinking, scientific writing, oral presenting, and familiarity with the complex ethics that will face tomorrow's national thought leaders as regenerative medicine research moves from bench to bedside. To prepare for tomorrow's challenges and augment diversity in the research workforce, this renewal includes an innovative, novel year-long Post- baccalaureate Research Education Program (PREP) that recruits students from backgrounds that are traditionally underrepresented in biomedical research. An additional, novel goal of this TL1 is to pioneer the development of regenerative medicine core competencies for the CTSA. These competencies will maintain rigor of training and equip scholars to become leaders in translational regenerative medicine research. Beyond training superb scholars, the many deliverables of this renewed RMTP will include shareable patient-specific stem cell repositories procured from at risk patient populations as well as from the entire Framingham Study cohort, sophisticated protocols that will allow any CTSA institution to prepare patient-derived organoids in vitro, and hands-on training courses or on line modules that will disseminate this expertise freely across the entire CTSA. This “open-source” approach to science is central to the mission of BU's Center for Regenerative Medicine, the physical home of many TL1 faculty, labs and resources.