NRSA Training Core

NRSA 培训核心

• 批准号: 10615243
• 负责人: Darrell N. Kotton
• 金额: $ 31.46万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-13 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615243
• 关键词: Administrator; Area; Biomedical Engineering; Biomedical Research; Boston; Clinical; Cohort Studies; Competence; Complex; Congresses; Creativeness; Critical Thinking; Development; Discipline; Disease model; Educational process of instructing; Ethics; Face; Faculty; Familiarity; Genes; Goals; Home; Human; In Vitro; Institution; Mentors; Mission; National Research Service Awards; Oral; Organoids; Patients; Pluripotent Stem Cells; Postbaccalaureate; Postdoctoral Fellow; Protocols documentation; Regenerative Medicine; Research; Resources; Risk; Science; Scientist; Student recruitment; TNFSF15 gene; Training; Training Programs; Translational Research; Universities; Writing; bench to bedside; cell bank; cell repository; clinical practice; clinical translation; education research; experience; innovation; novel; open source; patient population; pre-doctoral; precision medicine; programs; regenerative; stem cell biology; stem cells

The objective of this proposal is to provide rigorous training in all aspects of translational research related to regenerative medicine. There is a bourgeoning need for creative, critical, and responsible transdisciplinary scientists as thought leaders and administrators who will spearhead national efforts to bring regenerative medicine into widespread clinical practice. This national need was demonstrated by Congress's 21st Century Cures Act that established regenerative medicine as one of four national research areas in desperate need of clinical translation. This proposal integrates Boston University's marquee programs in biomedical engineering, pluripotent stem cell biology, human organoid in vitro disease modeling, precision medicine, gene editing, stem cell banking, and computational biomedicine to produce an extraordinarily rigorous and comprehensive training program in the emerging, futuristic discipline known broadly as “regenerative medicine.” This proposed renewal of the already successful Regenerative Training Program (RMTP), now in its 4th year, is geared to expanding and maturing this nascent program into a clinically-focused training experience for 6 pre-doctoral and 2 post- doctoral trainees. The proposed RMTP renewal incorporates mentored cross-disciplinary research, exciting courses taught by the leaders of these marquee programs, and additional training in critical thinking, scientific writing, oral presenting, and familiarity with the complex ethics that will face tomorrow's national thought leaders as regenerative medicine research moves from bench to bedside. To prepare for tomorrow's challenges and augment diversity in the research workforce, this renewal includes an innovative, novel year-long Post- baccalaureate Research Education Program (PREP) that recruits students from backgrounds that are traditionally underrepresented in biomedical research. An additional, novel goal of this TL1 is to pioneer the development of regenerative medicine core competencies for the CTSA. These competencies will maintain rigor of training and equip scholars to become leaders in translational regenerative medicine research. Beyond training superb scholars, the many deliverables of this renewed RMTP will include shareable patient-specific stem cell repositories procured from at risk patient populations as well as from the entire Framingham Study cohort, sophisticated protocols that will allow any CTSA institution to prepare patient-derived organoids in vitro, and hands-on training courses or on line modules that will disseminate this expertise freely across the entire CTSA. This “open-source” approach to science is central to the mission of BU's Center for Regenerative Medicine, the physical home of many TL1 faculty, labs and resources.

该提案的目的是在转化研究的各个方面提供严格的培训 对创造性，批判和负责任的跨学科的资产阶级需求 科学家作为思想领袖和行政人员，他们将率领国家努力带来重生 药物为广泛的临床实践。国会21世纪证明了这种国家需求 固化法案将再生医学确立为迫切需要的四个国家研究领域之一 临床翻译。该提案将波士顿大学的侯爵计划集成了生物医学工程， 多能干细胞生物学，人体器官体外疾病建模，精密医学，基因编辑，茎 细胞银行和计算生物医学，以产生非常严格和全面的培训 在新兴的，未来派的纪律中，被称为“再生医学”。这提出了续约 现在已经成功的第四年的已经成功的再生培训计划（RMTP）旨在扩展 并将这一新生计划融入以临床为中心的培训经验 博士学员。拟议的RMTP续订合并协会修补了跨学科研究，令人兴奋 这些侯爵计划的领导者教授的课程，以及批判性思维，科学的其他培训 写作，口头表现以及对将要面对明天的国民思想领袖的复杂伦理的熟悉 随着再生医学的研究从长凳转移到床边。为明天的挑战做准备 增强研究工作人员的多样性，这种更新包括创新的，新颖的一年后 学士学位研究教育计划（PREP）报告来自背景的学生 传统上，生物医学研究中的人为不足。此TL1的另一个新颖目标是开拓 开发CTSA的再生医学核心能力。这些能力将保持严格 培训并为学者提供了翻译的再生医学研究领导者。超过 培训精湛的学者，此重新获得的RMTP的许多可交付成果将包括可共享的特定患者 从风险患者人群以及整个弗雷明汉研究中采购的干细胞存储库 队列，复杂的协议，将允许任何CTSA机构在体外准备患者衍生的类器官， 以及动手培训课程或在线模块上，可以在整个过程中自由传播这一专业知识 CTSA。这种“开源”科学方法是BU再生中心使命的核心 医学，许多TL1教师，实验室和资源的物理住所。