Structure, function, and pharmacology of neuronal membrane transport proteins

神经元膜转运蛋白的结构、功能和药理学

• 批准号: 10687812
• 负责人: Seok-Yong Lee
• 金额: $ 79.07万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10687812
• 关键词: Cell membrane; Disease; Event; Future; Goals; Knowledge; Membrane Transport Proteins; Neurobiology; Neurons; Pain; Pharmacology; Pharmacology Study; Process; Property; Pruritus; Research; Structure; Therapeutic; chronic itch; chronic pain; design; pharmacologic; therapeutic development; tool

Project Summary Membrane transport proteins are responsible for the transport of key molecules and transfer of information across cell membranes, events that are central to many important neurobiological processes. They are designed to selectively recognize a variety of substrates of differing sizes and physicochemical properties for cellular transport. My overarching research goals are to understand the design principles of membrane transport proteins that allow for their selective transport, to develop pharmacological tools to modulate their function, and to utilize the knowledge gained to exploit their therapeutic potentials.

项目摘要 膜运输蛋白负责关键分子的运输和信息的传递 跨越细胞膜，这些事件是许多重要神经生物学过程的中心。他们是 被设计成选择性地识别各种不同大小和物理化学性质的底物 蜂窝传输。我的主要研究目标是了解膜的设计原理。 允许其选择性运输的运输蛋白，以开发药理工具来调节其 功能，并利用所获得的知识来开发其治疗潜力。