Structure, function, and pharmacology of neuronal membrane transport proteins

项目摘要 膜转运蛋白负责关键分子的转运和信息的传递 在细胞膜上，这些事件对许多重要的神经生物学过程至关重要。他们是 设计用于选择性地识别不同尺寸和物理化学性质的各种底物， 细胞运输我的首要研究目标是了解膜的设计原理， 转运蛋白，允许他们的选择性运输，开发药理学工具，以调节他们的 功能，并利用所获得的知识来开发其治疗潜力。

Project Summary Membrane transport proteins are responsible for the transport of key molecules and transfer of information across cell membranes, events that are central to many important neurobiological processes. They are designed to selectively recognize a variety of substrates of differing sizes and physicochemical properties for cellular transport. My overarching research goals are to understand the design principles of membrane transport proteins that allow for their selective transport, to develop pharmacological tools to modulate their function, and to utilize the knowledge gained to exploit their therapeutic potentials.