Strain Analysis Software for Open Science
开放科学应变分析软件
基本信息
- 批准号:10406113
- 负责人:
- 金额:$ 21.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAdoptionAgeAlgorithmsAreaBone RegenerationBone TissueClinical ResearchCloud ComputingCodeCollaborationsCommunitiesComputer softwareComputersConnective TissueDataData SetDevelopmentDiagnosisDiagnosticDiseaseElderlyEnsureFailureFrictionHealthHerniaImageImage AnalysisInjuryKnowledgeLaboratoriesLaboratory ResearchLeadLigamentsLiteratureMagnetic Resonance ImagingMechanicsMedical ImagingMeniscus structure of jointMesenteryMethodsModelingMuscleMusculoskeletalMyocardiumNoiseOperative Surgical ProceduresOrthopedicsOutcomePainPathologicPatientsPeritonealPia MaterPlant RootsPopulationRehabilitation therapyResearchResearch PersonnelResourcesRiskRotator CuffRunningSignal TransductionSoftware EngineeringStandardizationStressSurfaceSystemTechniquesTechnologyTendon structureTimeTissuesTranslatingTranslational ResearchUltrasonographyValidationWorkarticular cartilagebaseboneclinically relevantcloud basedcomputational platformcomputing resourcesdata modelingdigital imagingdisabilityimage warpingimaging modalityimprovedmechanical propertiesmicroscopic imagingmoviemusculoskeletal injuryolder patientopen dataopen sourceparallel computerparallelizationparent grantrepairedrotator cuff tearsoft tissuesoftware developmenttooltwo-dimensionaluser friendly software
项目摘要
PROJECT SUMMARY
The parent grant focuses on interfaces between tissues either transfer load (requiring toughness) or provide a
smooth surface (requiring low friction). Fibrous interfaces are very effective at transferring load between
tissues, e.g., at connective tissue-bone interfaces (“entheses”), peritoneal-mesentery interfaces, interfaces
between layers of the vasculature, and the pia mater. These interfaces require toughness to resist high
stresses associated with material mismatches. Surgical repair can lead to smooth interfaces becoming fibrous,
(e.g., following hernia surgery) or to tough interfaces becoming weak (e.g., following tendon- and ligament-to-
bone repair). In older patients with large rotator cuff repairs, for example, where the desired attachment is not
reformed, up to 94% of surgical repairs fail. These challenges arise in part because the features that endow
fibrous interfaces with toughness are not known. The parent grant there for aims to develop a comprehensive
modeling and experimental approach for studying the factors underlying the transition from tough to weak in a
fibrous interface.
The supplement proposes to take software that we have developed in the course of this work and make it
cloud-ready and broadly available. This software enables quantitative analysis of deformation in microscopy
and medical imaging. Although commercial software for this is widespread, these packages employ
regularization techniques to ensure a smooth solution, and are therefore often unable to accurately identify
local tissue deformations or predict soft tissue tears. We will enable research into the relation between strain
fields, injury, and rehabilitation by executing two aims. (1) We will develop open-source, user-friendly software
as a plugin to ImageJ for the strain-tracking algorithm in two dimensions (2D), stereo view (2.5D), and three
dimensions (3D). Best practices will be used for open source software development, and modules will be
created to facilitate the development of a user community. (2) We will develop a working, static code
implementation on GitHub that can be run on Amazon AWS using data in the cloud. This will help overcome
the second obstacle to widespread adoption of strain mapping techniques in musculoskeletal research, namely
that the 3D datasets that must be acquired require substantial computational resources to analyze. The work
will enable collaboration between the PIs of the parent grant and an expert on open source software
development for clinical and research translation, and enhance the impact of a tool with strong potential.
项目摘要
母基金的重点是组织之间的界面,要么转移负荷(需要韧性),要么提供一个
光滑表面(要求低摩擦)。纤维界面在将负载在
组织,例如,在结缔组织-骨界面(“附着点”)、腹膜-肠系膜界面、界面
在血管系统和软脑膜之间。这些界面需要韧性来抵抗高温。
与材料不匹配相关的应力。手术修复可能导致光滑的界面变成纤维状,
(e.g.,在疝手术之后)或坚韧的界面变得脆弱(例如,在肌腱和韧带
骨修复)。例如,在进行大型肩袖修复的老年患者中,
经过改革,高达94%的手术修复失败。这些挑战之所以出现,部分原因是
具有韧性的纤维界面是未知的。那里的父母补助金旨在制定一个全面的
模拟和实验方法,研究从坚韧到软弱的转变,
纤维界面
该补充建议采取我们在这项工作的过程中开发的软件,
云就绪且广泛可用。该软件可以对显微镜中的变形进行定量分析
和医学成像。虽然商业软件是广泛的,这些软件包采用
正则化技术,以确保顺利的解决方案,因此往往无法准确地识别
局部组织变形或预测软组织撕裂。我们将能够研究应变与
领域,伤害和康复,通过执行两个目标。(1)我们将开发开源的、用户友好的软件
作为ImageJ的插件,用于二维(2D)、立体视图(2.5D)和三维(3D)中的应变跟踪算法。
尺寸(3D)。最佳实践将用于开源软件开发,模块将
它是为了促进用户社区的发展而创建的。(2)我们将开发一个工作的静态代码
GitHub上的实现,可以使用云中的数据在Amazon AWS上运行。这将有助于克服
在肌肉骨骼研究中广泛采用应变绘图技术的第二个障碍,即
必须获取的3D数据集需要大量的计算资源来分析。工作
将使父母补助金的PI和开源软件专家之间的合作成为可能
为临床和研究翻译开发,并增强具有强大潜力的工具的影响。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Guy M Genin其他文献
Guy M Genin的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Guy M Genin', 18)}}的其他基金
Multiscale models of fibrous interface mechanics
纤维界面力学的多尺度模型
- 批准号:
10476994 - 财政年份:2020
- 资助金额:
$ 21.01万 - 项目类别:
Multiscale models of fibrous interface mechanics
纤维界面力学的多尺度模型
- 批准号:
10037326 - 财政年份:2020
- 资助金额:
$ 21.01万 - 项目类别:
Multiscale models of fibrous interface mechanics
纤维界面力学的多尺度模型
- 批准号:
10678848 - 财政年份:2020
- 资助金额:
$ 21.01万 - 项目类别:
Multiscale models of fibrous interface mechanics
纤维界面力学的多尺度模型
- 批准号:
10897549 - 财政年份:2020
- 资助金额:
$ 21.01万 - 项目类别:
Multiscale models of fibrous interface mechanics
纤维界面力学的多尺度模型
- 批准号:
10222575 - 财政年份:2020
- 资助金额:
$ 21.01万 - 项目类别:
Multiscale models of fibrous interface mechanics
纤维界面力学的多尺度模型
- 批准号:
10601609 - 财政年份:2020
- 资助金额:
$ 21.01万 - 项目类别:
Cross-scale interactions between mineral and collagen for tendon-bone attachment
矿物质和胶原蛋白之间的跨尺度相互作用,用于腱骨附着
- 批准号:
9342878 - 财政年份:2013
- 资助金额:
$ 21.01万 - 项目类别:
Cross-scale interactions between mineral and collagen for tendon-bone attachment
矿物质和胶原蛋白之间的跨尺度相互作用,用于腱骨附着
- 批准号:
8551256 - 财政年份:2013
- 资助金额:
$ 21.01万 - 项目类别:
Cross-scale interactions between mineral and collagen for tendon-bone attachment
矿物质和胶原蛋白之间的跨尺度相互作用,用于腱骨附着
- 批准号:
8913701 - 财政年份:2013
- 资助金额:
$ 21.01万 - 项目类别:
Cross-scale interactions between mineral and collagen for tendon-bone attachment
矿物质和胶原蛋白之间的跨尺度相互作用,用于腱骨附着
- 批准号:
8723201 - 财政年份:2013
- 资助金额:
$ 21.01万 - 项目类别:
相似海外基金
WELL-CALF: optimising accuracy for commercial adoption
WELL-CALF:优化商业采用的准确性
- 批准号:
10093543 - 财政年份:2024
- 资助金额:
$ 21.01万 - 项目类别:
Collaborative R&D
Investigating the Adoption, Actual Usage, and Outcomes of Enterprise Collaboration Systems in Remote Work Settings.
调查远程工作环境中企业协作系统的采用、实际使用和结果。
- 批准号:
24K16436 - 财政年份:2024
- 资助金额:
$ 21.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 21.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 21.01万 - 项目类别:
EU-Funded
Assessing the Coordination of Electric Vehicle Adoption on Urban Energy Transition: A Geospatial Machine Learning Framework
评估电动汽车采用对城市能源转型的协调:地理空间机器学习框架
- 批准号:
24K20973 - 财政年份:2024
- 资助金额:
$ 21.01万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 21.01万 - 项目类别:
EU-Funded
Our focus for this project is accelerating the development and adoption of resource efficient solutions like fashion rental through technological advancement, addressing longer in use and reuse
我们该项目的重点是通过技术进步加快时装租赁等资源高效解决方案的开发和采用,解决更长的使用和重复使用问题
- 批准号:
10075502 - 财政年份:2023
- 资助金额:
$ 21.01万 - 项目类别:
Grant for R&D
Engage2innovate – Enhancing security solution design, adoption and impact through effective engagement and social innovation (E2i)
Engage2innovate — 通过有效参与和社会创新增强安全解决方案的设计、采用和影响 (E2i)
- 批准号:
10089082 - 财政年份:2023
- 资助金额:
$ 21.01万 - 项目类别:
EU-Funded
De-Adoption Beta-Blockers in patients with stable ischemic heart disease without REduced LV ejection fraction, ongoing Ischemia, or Arrhythmias: a randomized Trial with blinded Endpoints (ABbreviate)
在没有左心室射血分数降低、持续性缺血或心律失常的稳定型缺血性心脏病患者中停用β受体阻滞剂:一项盲法终点随机试验(ABbreviate)
- 批准号:
481560 - 财政年份:2023
- 资助金额:
$ 21.01万 - 项目类别:
Operating Grants
Collaborative Research: SCIPE: CyberInfrastructure Professionals InnoVating and brOadening the adoption of advanced Technologies (CI PIVOT)
合作研究:SCIPE:网络基础设施专业人员创新和扩大先进技术的采用 (CI PIVOT)
- 批准号:
2321091 - 财政年份:2023
- 资助金额:
$ 21.01万 - 项目类别:
Standard Grant