Multi-Scale Modeling of SARS-CoV-2 Dissemination Dynamics

项目摘要--总体构成部分 尽管传染病在20世纪和21世纪初取得了惊人的进步，但它是动态的、不断演变的 在全世界所有人口中造成重大发病率和死亡率的全球性威胁。在一年内， 寨卡病毒出现，霍乱大规模爆发，抗菌素耐药性成为一种 关键的国际关切。这一形势需要新的方法来预防和控制传染病 以及培训新的科学家以满足这些需求。新的方法将需要解释 大数据集的数据，包括来自生物科学(“系统生物学”和“组学”)和高级 流行病学。佛蒙特大学科布雷分校将专注于翻译研究，以预防和 控制全球传染病。“TGIR中心”(翻译全球传染病研究) 将整合一个由生物医学和数学/计算科学家组成的新的多学科研究团队。 该团队将致力于新颖和有影响力的研究，以减轻具有全球重要性的传染性疾病的负担 通过弥合生物和数学/计算领域之间的文化鸿沟 生物医学研究。我们的中心将充分利用UVM在全球传染病方面的现有优势 疾病研究，以及在复杂系统和计算建模方面的优势。一支经验丰富的团队 董事、科学顾问/导师和两个新的核心设施(数学和计算预测 建模“和”人类与人口研究“)将促进合作和新颖的研究。TGIR将 在三名高级科学顾问的指导下培养四名优秀的现有初级教员 密歇根州立大学学院和五个系。机构支持将有助于招聘三名新的初级教员 并将为一个新的创新与协作实验室提供空间，后者也得到 拟议的改建和翻新部分。内部和外部咨询委员会将提供正式的、 不带偏见的监督。初级教员将在TGIR Cobre找到一个强大、组织良好的学术之家：A 强大的指导和职业发展计划，中心范围内的系列研讨会和课程，以及 来自两个研究中心的多学科资深教员团队的研究支持。

PROJECT SUMMARY – Overall Component Despite striking advances in the 20th and early 21st century, infectious diseases are dynamic, ever-evolving global threats that cause significant morbidity and mortality in all populations worldwide. Within a single year, Zika has emerged, massive outbreaks of cholera have occurred, and antimicrobial resistance has become a critical international concern. This landscape demands new approaches to prevent and control infectious diseases, and the training of new scientists to meet these demands. New approaches will require interpretation of big data sets, including data from both the biologic sciences (“systems biology” and “-omics”) and advanced epidemiology. This University of Vermont COBRE will be focused on Translational Research to Prevent and Control Global Infectious Diseases. “The TGIR Center” (Translational Global Infectious Diseases Research) will integrate a novel multi-disciplinary research team of biomedical and mathematical/computational scientists. The team will work toward novel and impactful research to diminish the burden of globally-important infectious diseases by bridging the culture gaps between the biologic and mathematical/computational fields of biomedical research. Our center will leverage substantial existing strengths at UVM in Global Infectious Diseases Research, and strengths in complex systems and computational modeling. A team of experienced directors, scientific advisors/mentors, and two new core facilities (“Mathematical and Computational Predictive Modeling” and “Human and Population Research”), will foster collaborative and novel research. The TGIR will develop four outstanding, existing junior faculty under the mentorship of senior scientific advisors from three UVM colleges and five departments. Institutional support will enable recruitment of three new junior faculty and will provide space for a new Innovation and Collaboration laboratory, the latter also supported by the proposed Alteration and Renovation component. Internal and external advisory committees will provide formal, unbiased oversight. Junior faculty will find a robust, well-organized academic home in the TGIR COBRE: a strong mentoring and career-development program, a center-wide seminar series and coursework, and research support from multi-disciplinary senior faculty teams in both research cores.