Translational Research to Prevent and Control Global Infectious Diseases (Translational Global Infectious Diseases Research Center, TGIR).

预防和控制全球传染病的转化研究（转化全球传染病研究中心，TGIR）。

• 批准号: 10021005
• 负责人: Beth Diane Kirkpatrick
• 金额: $ 220.67万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10021005
• 关键词: Advisory Committees; Antimicrobial Resistance; Big Data; Biological; Biological Sciences; Biomedical Research; Center for Translational Science Activities; Centers of Research Excellence; Cholera; Clinical; Clinical Trials; Collaborations; Communicable Diseases; Complement; Complex; Computer Models; Core Facility; Data; Data Set; Development; Discipline; Disease Outbreaks; Epidemiology; Faculty; Faculty Recruitment; Fostering; Goals; Growth; Home environment; Human; Immunology; Infectious Diseases Research; Interdisciplinary Study; International; Laboratories; Lead; Mathematics; Mentors; Mentorship; Methods; Molecular; Morbidity - disease rate; Parasitology; Physicians; Population; Population Research; Prevention; Program Development; Research; Research Infrastructure; Research Personnel; Research Support; Science; Scientist; Series; Structure; System; Systems Biology; Talents; Teacher Professional Development; Training; Translational Research; Universities; Vaccines; Vermont; Work; ZIKA; career development; college; design; experience; global health; improved; innovation; interest; member; mortality; multidisciplinary; novel; novel strategies; novel therapeutics; predictive modeling; prevent; programs; recruit; senior faculty; success; symposium; synergism

PROJECT SUMMARY – Overall Component Despite striking advances in the 20th and early 21st century, infectious diseases are dynamic, ever-evolving global threats that cause significant morbidity and mortality in all populations worldwide. Within a single year, Zika has emerged, massive outbreaks of cholera have occurred, and antimicrobial resistance has become a critical international concern. This landscape demands new approaches to prevent and control infectious diseases, and the training of new scientists to meet these demands. New approaches will require interpretation of big data sets, including data from both the biologic sciences (“systems biology” and “-omics”) and advanced epidemiology. This University of Vermont COBRE will be focused on Translational Research to Prevent and Control Global Infectious Diseases. “The TGIR Center” (Translational Global Infectious Diseases Research) will integrate a novel multi-disciplinary research team of biomedical and mathematical/computational scientists. The team will work toward novel and impactful research to diminish the burden of globally-important infectious diseases by bridging the culture gaps between the biologic and mathematical/computational fields of biomedical research. Our center will leverage substantial existing strengths at UVM in Global Infectious Diseases Research, and strengths in complex systems and computational modeling. A team of experienced directors, scientific advisors/mentors, and two new core facilities (“Mathematical and Computational Predictive Modeling” and “Human and Population Research”), will foster collaborative and novel research. The TGIR will develop four outstanding, existing junior faculty under the mentorship of senior scientific advisors from three UVM colleges and five departments. Institutional support will enable recruitment of three new junior faculty and will provide space for a new Innovation and Collaboration laboratory, the latter also supported by the proposed Alteration and Renovation component. Internal and external advisory committees will provide formal, unbiased oversight. Junior faculty will find a robust, well-organized academic home in the TGIR COBRE: a strong mentoring and career-development program, a center-wide seminar series and coursework, and research support from multi-disciplinary senior faculty teams in both research cores.

项目摘要 – 总体组成部分 尽管在 20 世纪和 21 世纪初取得了惊人的进步，但传染病仍然是动态的、不断发展的 造成全世界所有人口显着发病和死亡的全球威胁。一年之内， 寨卡病毒出现，霍乱大规模爆发，抗生素耐药性已成为一个问题 国际社会的严重关切。这种情况需要新的方法来预防和控制传染病 疾病，以及培训新科学家以满足这些需求。新方法需要解释 大数据集，包括来自生物科学（“系统生物学”和“组学”）和先进科学的数据 流行病学。佛蒙特大学 COBRE 将专注于预防和预防转化研究 控制全球传染病。 “TGIR 中心”（转化全球传染病研究） 将整合一个由生物医学和数学/计算科学家组成的新颖的多学科研究团队。 该团队将致力于新颖且有影响力的研究，以减轻全球重要传染病的负担 通过弥合生物和数学/计算领域之间的文化差距来治疗疾病 生物医学研究。我们的中心将利用 UVM 在全球传染病领域的现有优势 疾病研究，以及复杂系统和计算建模方面的优势。经验丰富的团队 董事、科学顾问/导师和两个新的核心设施（“数学和计算预测 建模”和“人类和人口研究”）将促进协作和新颖的研究。TGIR 将 在来自三名高级科学顾问的指导下培养四名优秀的现有初级教师 UVM 学院和五个系。机构支持将有助于招聘三名新的初级教师 并将为新的创新与合作实验室提供空间，后者也得到了 拟议的改建和翻新部分。内部和外部咨询委员会将提供正式的、 公正的监督。初级教师将在 TGIR COBRE 找到一个强大、组织良好的学术家园： 强有力的指导和职业发展计划、中心范围的研讨会系列和课程，以及 两个研究核心的多学科高级教师团队的研究支持。