Translational Global Infectious Diseases Research Center

项目总结：总体 正如新冠肺炎大流行所表明的那样，传染病是动态的、不断演变的威胁 在全世界所有人口中造成严重的发病率和死亡率。佛蒙特大学翻译学院 全球传染病研究(TGIR)生物医学研究卓越中心(COBRE)于 2018年，根据第一阶段奖，旨在支持和发展下一代 并在全球传染病研究方面建立机构力量。TGIR Cobre的 最重要的科学目标是进行有影响力的研究，以预防和控制全球传染病 特别是在世界资源匮乏的地区，气候变化具有重要意义。TGIR Cobre的一个独特功能是它的 致力于弥合生物医学和定量数据科学家之间的文化鸿沟。第一阶段资金 成功地支持了7名研究项目负责人(RPL)，招聘了4名新的初级教员，并开始了 试点奖励计划，资助另外九个研究项目。提供的管理核心 全面的科学、管理和职业发展支持，以及新的教育和学术 计划，包括辅导和访问学者计划。两个研究核心--人与人 人口研究(HPR)核心和数学和计算预测模型(MCP)核心- 直接为RPL、试点项目获奖者和初级教职员工提供优先服务 教育和培训机会。 TGIR Cobre的第二阶段将建立和巩固这一机构增长和临界师资队伍， 包括“毕业”的RPL的留任机会。主要专注于发展初级教员，以及 在资深导师和改进的导师计划的帮助下，TGIR Cobre最初将支持 四名RPL的职业和研究，以及新的飞行员奖励教师。三名外部招聘的教职员工将 补充现有研究领域的实力。此外，TGIR Cobre将专注于RPL管道 教职员工和扩大校园内的合作以及与其他IDEA州项目的合作。与机构合作 支持，第二阶段的新举措将使TGIR Cobre获得长期成功。这些倡议 包括多学科赠款提案的计划和提供正式赠款编写人的支助。财务和 还将为在密歇根大学举行的国家科学会议提供后勤支助，以扩大 网络、可见性和协作机会。MCP核心增加了一名生物信息学家， 扩展的数据管理和生物存储库服务已添加到HPR核心，并且 管理核心现在加强了对内科科学家职业发展的关注。评估 TGIR Cobre的进展将是一个持续的过程，由领导团队领导，并在 专门的咨询委员会。我们期待TGIR Cobre成为一项可持续的学术研究 全球传染病中心。

PROJECT SUMMARY: Overall As demonstrated by the COVID-19 pandemic, infectious diseases are dynamic, constantly evolving threats that cause significant morbidity and mortality in all populations worldwide. The University of Vermont’s Translational Global Infectious Diseases Research (TGIR) Center of Biomedical Research Excellence (COBRE) began in 2018 under a Phase 1 award with aims to support and develop the research careers of the next generation of scientists and to build institutional strength in global infectious disease research. The TGIR COBRE’s overarching scientific goal is to perform impactful research to prevent and control infectious diseases of global significance, particularly in low-resource regions of the world. A unique feature of the TGIR COBRE is its commitment to bridging the culture gap between biomedical and quantitative data scientists. Phase 1 funding successfully supported seven research project leaders (RPLs), recruited four new junior faculty, and began a pilot award program that funded nine additional research projects. The Administrative Core offered comprehensive scientific, administrative, and career-development support, and new educational and academic programs, including Mentoring and Visiting Scholar Programs. The two research cores - the Human and Population Research (HPR) Core and the Mathematical and Computational Predictive Modeling (MCP) Core – provided prioritized services directly to RPLs, pilot project awardees, and junior faculty recruits in addition to educational and training opportunities. Phase 2 of the TGIR COBRE will build and consolidate this institutional growth and critical mass of faculty, including retention opportunities for ‘graduated’ RPLs. With a primary focus on developing junior faculty, and with the help of senior mentors and an improved mentoring plan, the TGIR COBRE will initially support the careers and research of four RPLs as well as new pilot award faculty. Three externally recruited faculty will complement existing areas of research strength. In addition, the TGIR COBRE will focus on RPL pipeline faculty and on broadening collaborations across campus and with other IDeA state programs. With institutional support, new initiatives in Phase 2 will position the TGIR COBRE for long term success. These initiatives include plans for multi-disciplinary grant proposals and provision of formal grant writer support. Financial and logistic support will also be provided for national scientific meetings to be held at UVM in order to broaden networking, visibility, and collaborative opportunities. A bioinformatician has been added to the MCP Core, expanded data management and biorepository services have been added to the HPR Core, and the Administrative Core now has enhanced focus on career development for physician-scientists. Evaluation of TGIR COBRE progress will be a continuous process led by the Leadership Team with the support of a dedicated Advisory Committee. We anticipate the TGIR COBRE becoming a sustainable academic research hub in global infectious diseases.