Brain Structure in Adults with FASD - L. Aguilar diversity supplement

患有 FASD 的成人的大脑结构 - L. Aguilar 多样性补充

• 批准号: 10403345
• 负责人: Eileen Marie Moore
• 金额: $ 4.71万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10403345
• 关键词: Adult; Age; Alcoholism; Award; Bayesian Modeling; Behavioral; Brain; Brain Mapping; Characteristics; Child; Classification; Cognitive; Computer software; Data; Data Set; Face; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Development; Fetal alcohol effects; Goals; Growth; Human; Individual; Knowledge; MRI Scans; Master' s Degree; Outcome; Parents; Process; Public Health; Research; Sampling; Scanning; Shapes; Societies; Structure; System; Techniques; Training; age group; age related; brain behavior; brain research; career; career development; follow-up; improved; interest; neuroimaging; parent grant; programs; recruit; sex; skills; symposium; young adult

Project Summary Prenatal alcohol exposure can have devastating effects on the developing fetus, including growth deficits, cognitive and behavioral anomalies, alterations in brain, and distinct facial characteristics; collectively these are referred to as fetal alcohol spectrum disorders (FASD). While there has been much research examining the brain and behavior in children with FASD, very little data exists on adults. Many of the consequences of PAE are thought to be lifelong, yet data on individuals past young adulthood are rare. Previous large studies from Seattle, WA developed well-characterized research samples of individuals with a classification of having an FASD and age- and sex-matched controls. One-hundred-eighty of these subjects completed T1- weighted MRI scans approximately 20 years ago. Fifty of these previously scanned subjects have already been recruited to complete a follow-up T1-weighted MRI scan as part of the parent award. The aim of the parent award is to evaluate the protracted effects of prenatal alcohol exposure on the brain, particularly within the frontal executive system from the aforementioned dataset. This project expands upon the parent grant by evaluating additional age-related changes in the brain within subcortical regions of interest (ROIs). This supplement will support the trainee, Lindsey Aguilar, as she acquires skills in human neuroimaging research and contributes to the goals of the parent award, “Brain maturation in adults with FASD.” More specifically, Ms. Aguilar will utilize available neuroimaging software programs to apply a Bayesian model of shape to subcortical ROIs for baseline and follow-up scan data. For Aim 1, she will process the baseline data with two different techniques for estimating probable shape (FSL/FIRST and FreeSurfer with Enigma pipeline) to determine which pipeline is most effective. After choosing the more appropriate pipeline, she will compare shape differences in adults with FASD as compared to matched controls using the follow-up data. As part of her training plan, she will complete tutorials and short courses offered by both FreeSurfer and FSL, attend and present her data at the Human Brain Mapping and Research Society on Alcoholism conferences. Additionally, she will be completing career development activities as she earns her master’s degree and pursues a research career studying the impact of prenatal alcohol exposure on the brain.

项目摘要 产前酒精暴露会对发育中的胎儿产生破坏性影响，包括 生长缺陷，认知和行为异常，大脑改变，以及不同的面部特征 胎儿酒精谱系障碍（FASD）是指胎儿酒精谱系障碍（FASD）。 虽然有很多研究检查了FASD儿童的大脑和行为， 关于成年人的数据很少。PAE的许多后果被认为是终身的，然而， 关于青年期之后的个人的数据很少。之前在华盛顿州西雅图进行的大型研究 开发了具有良好特征的个人研究样本， FASD和年龄和性别匹配的对照。这些受试者中有180人完成了T1- 做过磁共振扫描这些先前扫描的受试者中有50人 已经招募完成随访T1加权MRI扫描，作为父母的一部分 奖父母奖的目的是评估产前酒精的长期影响 暴露在大脑中，特别是在前面提到的额叶执行系统中， 数据集。该项目通过评估额外的年龄相关的 大脑皮层下感兴趣区域（ROI）的变化。该补充将支持 受训者，林赛阿吉拉尔，因为她获得了人类神经成像研究的技能， 有助于家长奖的目标，“大脑成熟的成人FASD。”更 具体来说，阿吉拉尔女士将利用现有的神经成像软件程序， 基线和随访扫描数据的皮质下ROI形状的贝叶斯模型。对于目标1， 她将用两种不同的技术处理基线数据， (FSL/FIRST和FreeSurfer with Enigma pipeline），以确定哪个管道最有效。 在选择了更合适的管道后，她将比较成年人的形状差异， 使用随访数据与匹配的对照组进行比较。作为她训练计划的一部分， 她将完成FreeSurfer和FSL提供的教程和短期课程，参加并 在人类大脑映射和酒精中毒研究协会上展示了她的数据 两会此外，她将完成职业发展活动，因为她赢得了她的 硕士学位，并从事研究产前酒精的影响 暴露在大脑中。