Xenbase: a Xenopus Model Organism Knowledgebase

Xenbase：非洲爪蟾模型生物知识库

• 批准号: 10404996
• 负责人: PETER D VIZE
• 金额: $ 159.63万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404996
• 关键词: ATAC-seq; Aloral; Animal Model; Atlases; Biological; Biomedical Research; Cells; Cellular biology; ChIP-seq; Communities; Computer software; Consumption; DNA methylation profiling; Data; Data Set; Databases; Development; Disease; Disease model; FAIR principles; Funding; Gene Expression; Gene Expression Process; Genes; Genomics; Genotype; Gold; Grant; Growth; Health; Human; Human Biology; Infrastructure; Investments; Knowledge; Letters; Link; Mission; Names; Operating System; Output; Paper; Phenotype; Play; Process; Proteomics; Publications; Publishing; Research; Research Personnel; Resources; Role; Source; Time; Transgenic Organisms; Translating; Translations; United States National Institutes of Health; Update; Variant; Visualization; Visualization software; XCL1 gene; XenBase; Xenopus; bioinformatics pipeline; bioinformatics tool; data exchange; data integration; data management; data mining; data sharing; experience; experimental study; gene regulatory network; human DNA; human disease; human model; improved; knowledgebase; large scale data; mutant; novel; online resource; ontology development; phenotypic data; relational database; repository; tool; transcriptome sequencing; usability; user-friendly; web-accessible; xenopus genome

Component: OVERALL PROJECT SUMMARY/ABSTRACT Xenbase is the Xenopus Model Organism Knowledgebase (MOK), an online resource that integrates all genomic and biological data from Xenopus research. Our mission is to accelerate the translation of Xenopus research into knowledge that will improve human health. We aim to empower Xenopus research and enhance the impact of Xenopus data in the broader biomedical community, as animal models, such as Xenopus, are essential for biomedical research and have led to a wealth of discoveries. Xenbase is user-friendly, allowing investigators to quickly find and link different data types in ways that would otherwise be difficult, time consuming, or impossible. It provides high quality curation, data integration, and bioinformatics tools to link Xenopus data to humans and other model organisms, NCBI, UniProt, Ensembl and other resources. In this post genomic era, with thousands of scientific publications annually, and the exponential growth of “omic” datasets, Xenbase is essential to translate the enormous amount of data generated from research using Xenopus into meaningful connected data. Xenbase, thus, plays an essential role in maximizing NIH’s >$120 million annual investment in Xenopus research. Xenbase is an essential resource for hundreds of labs around the world. There is a clear need to continue curating Xenopus data, to develop new tools to keep up with technological advances, and link Xenopus data to human biology in novel and insightful ways. Many of the letters of support (more than 110) state that labs could not function without Xenbase, and renewed funding for Xenbase was identified as the top priority in the 2020 Xenopus research community white paper.

组件：整体 项目摘要/摘要 Xenbase是Xenopus模式生物知识库(MOK)，这是一个在线资源， 整合了来自非洲爪哇研究的所有基因组和生物数据。我们的使命是加速 将非洲爪哇的研究转化为将改善人类健康的知识。我们的目标是 支持非洲爪哇研究并增强非洲爪哇数据在更广泛的生物医学领域的影响 社区，因为动物模型，如非洲爪哇，是生物医学研究和 带来了大量的发现。Xenbase用户友好，使调查人员能够快速 以其他方式查找和链接不同的数据类型，否则会很困难、耗时或 不可能。它提供高质量的管理、数据集成和生物信息学工具来链接 非洲爪哇向人类和其他模式生物、NCBI、UniProt、EnSembl和其他组织提供数据 资源。在这个后基因组时代，每年有成千上万的科学出版物， 随着经济数据集的指数级增长，Xenbase是翻译海量数据的关键 将使用Xenopus的研究产生的数据转换为有意义的连接数据。Xenbase， 因此，在最大限度地提高美国国立卫生研究院对非洲爪哇每年1.2亿美元的投资方面起着至关重要的作用 研究。Xenbase是世界各地数百个实验室的重要资源。有一个 显然需要继续管理Xenopus数据，开发新的工具以跟上 技术进步，并以新颖和有洞察力的方式将非洲爪哇数据与人类生物学联系起来。 许多支持信(110多封)指出，没有实验室就不能运作 Xenbase，为Xenbase重新提供资金被确定为2020年的首要任务 非洲爪哇研究社区白皮书。