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Xenbase: a Xenopus Model Organism Database

Xenbase：非洲爪蟾模式生物数据库

基本信息

批准号：
8292203
负责人：
PETER D VIZE
金额：
$ 84.35万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8292203
关键词：
African Amino Acid Sequence Animal Model Biochemical Bioinformatics Biological Biological Models Cells Communities Complementary DNA Data Data Analyses Data Sources Databases Development Developmental Cell Biology Disease Education Embryo Embryology Expressed Sequence Tags Funding Future Gene Expression Generations Genes Genome Genomics Goals Health Human Human Genome Image Instruction Length Link Literature Manuals Maps Messenger RNA Microarray Analysis Microinjections Mining National Institute of Child Health and Human Development Orthologous Gene Pathway interactions Peptide Sequence Determination Phenotype Play Process Proteins Publications RNA Splicing Rana Regulator Genes Research Research Personnel Resources Role Services System TACSTD1 gene Testing Transgenic Organisms Variant Vertebrates Xenopus Xenopus laevis comparative data mining egg empowered functional genomics gain of function gene function high throughput screening improved in vivo insight member model organisms databases mutant success tool

项目摘要

Animal models provide powerful experimental tools to test gene function and interrogate biological pathways. Comparative functional genomics between humans and model organisms has led to a wealth of discoveries, and it is clear that this will continue to play an important role in unlocking the potential of the genome for human health. In this post genomic era highly annotated and easily accessible data are increasingly essential for researchers to integrate vast amounts of sequence, expression and functional data into a meaningful biological synthesis. The goal of this proposal is to maintain and enhance Xenbase; the Xenopus model organism database. The African frogs Xenopus has long been one of the premiere model organisms used by cell and developmental biologists, providing numerous fundamental insights. The large and abundant Xenopus embryos enable sophisticated embryology, easy manipulation of gene expression by microinjection and biochemical analyses. Together with recent advances in genome and EST sequencing, the generation of full-length cDNA sets, microarray analysis, functional genomics screens, gene knockdown using anitsense morpholino oligos, the development of rapid transgenics and the establishment of Xenbase has made Xenopus a powerful system for functional genomics. Xenbase is a comprehensive database that provides a portal to inter-related Xenopus data including genomic, mRNA and protein sequence, gene expression, function and publications, which is all highly integrated with NCBI and other model organism databases. The goal of this proposal is to maintain and expand Xenbase. Aim 1) Maintain and further curate the data in Xenbase by implementing Testpresso data mining and manual curation. Aim 2) Enhance Xenbase functionality by introducing morpholino and mutant phenotypes. Aim 3) Support new content on Xenbase gene pages including mRNA splicing microarrays, and a Xenopus WIKI. Aim 4) Continue and expand collaborative research and service efforts by further integrating Xenbase data with NCBI and other model organism data bases. This proposal will empower Xenopus research and provide the broader scientific community a means of accessing a wealth of Xenopus data.

动物模型为测试基因功能和询问生物学问题提供了强有力的实验工具