Xenbase: The Xenopus model organism database

 描述(由申请人提供)：Xenbase，非洲爪哇模式生物数据库，是一个可在网上访问的资源，整合了非洲爪哇研究中所有不同的基因组和生物学数据。Xenbase的目标是增强非洲爪哇研究的能力，增强非洲爪哇研究数据的影响，并促进这些数据的传播。非洲爪蛙是用于生物医学研究的主要脊椎动物模型之一。人类与非洲爪哇等模式生物之间的比较功能基因组学带来了丰富的发现，在这个后基因组时代，每年有数千篇科学论文发表，大规模数据集呈指数级增长，Xenbase等资源对于将这些庞大的数据转化为有意义的生物合成至关重要。Xenbase是Xenopus研究产生的海量数据的唯一中央存储库。我们的关系数据库和用户友好界面使这些数据易于查询，并允许调查人员以其他方式快速询问和链接不同的数据类型，否则将很难、耗时或不可能。Xenbase还通过高质量的管理、数据集成、提供针对非洲爪哇实验优化的生物信息学工具，以及将非洲爪哇数据与人类和其他模式生物联系起来，提高了非洲爪哇数据的价值。Xenbase通过不断向NCBI、UniProtKB和EnSemble等组织提供带注释的数据更新，在使Xenopus数据可供更广泛的生物医学界访问方面发挥着不可或缺的作用。Xenbase加速了发现，使研究人员能够在非洲爪哇的分子途径和人类疾病之间建立新的联系。Xenbase在最大限度地发挥NIH每年约1.3亿美元对Xenopus研究的投资方面发挥了重要作用。这项提议的目标是维护和扩大Xenbase。我们的目标是：Aim1维护Xenbase并继续管理非洲爪哇研究数据目标2开发对Xenopus人类疾病模型的支持目标3加强对新数据类型、生物信息学工具和数据共享基础设施的支持

 DESCRIPTION (provided by applicant): Xenbase, the Xenopus model organism database, is a web accessible resource that integrates all the diverse genomic and biological data from Xenopus research. The goal of Xenbase is to empower Xenopus research, enhance the impact of Xenopus research data and to facilitate the dissemination of this data. Xenopus frogs are one of the major vertebrate animal models used for biomedical research. Comparative functional genomics between humans and model organisms such as Xenopus have led to a wealth of discoveries and in this post genomic era and with thousands of scientific publications annually and the exponential growth of large-scale datasets, resources such as Xenbase are essential to translate this vast body of data into a meaningful biological synthesis. Xenbase is the only central repository for the enormous amount of data generated from Xenopus research. Our relational database and user-friendly interface make this data easy to query, and allows investigators to quickly interrogate and link different data types in ways that would otherwise be difficult, time consuming, or impossible. Xenbase also enhances the value of Xenopus data through high quality curation, data integration, providing bioinformatics tools optimized for Xenopus experiments, and by linking Xenopus data to humans and other model organisms. Xenbase plays an indispensable role in making Xenopus data accessible to the broader biomedical community by continually providing annotated data updates to organizations such as NCBI, UniProtKB and Ensemble. Xenbase accelerates discovery, enabling investigators to make novel connections between molecular pathway in Xenopus and human disease. Xenbase plays an essential role in maximizing the NIH's ~$130 million annual investment in Xenopus research. The Goal of this proposal is to maintain and expand Xenbase. Our Aims, developed through extensive input from the community are: Aim1 Maintain Xenbase and continue curation of Xenopus research data Aim 2 Develop support for Xenopus models of human diseases Aim 3 Enhance support for new data types, bioinformatics tools and data sharing infrastructure