Xenbase: a Xenopus Model Organism Knowledgebase

Xenbase：非洲爪蟾模型生物知识库

• 批准号: 10674802
• 负责人: PETER D VIZE
• 金额: $ 164.68万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10674802
• 关键词: ATAC-seq; Acceleration; Aloral; Animal Model; Atlases; Biological; Biomedical Research; Cells; Cellular biology; ChIP-seq; Communities; Computer software; Consumption; DNA methylation profiling; Data; Data Set; Databases; Development; Disease; Disease model; FAIR principles; Funding; Gene Expression; Gene Expression Process; Genes; Genomics; Genotype; Grant; Growth; Health; Human; Human Biology; Infrastructure; Investments; Knowledge; Letters; Link; Mission; Names; Operating System; Output; Paper; Phenotype; Play; Process; Proteomics; Publications; Publishing; Research; Research Personnel; Resources; Role; Source; Technology; Time; Translating; Translations; United States National Institutes of Health; Update; Variant; Visualization; Visualization software; XCL1 gene; XenBase; Xenopus; bioinformatics pipeline; bioinformatics tool; data exchange; data integration; data management; data mining; data sharing; empowerment; experience; experimental study; gene regulatory network; human DNA; human disease; human model; improved; knowledgebase; large scale data; model organism; mutant; novel; online resource; ontology development; phenotypic data; relational database; repository; tool; transcriptome sequencing; usability; user-friendly; web-accessible; xenopus genome

Component: OVERALL PROJECT SUMMARY/ABSTRACT Xenbase is the Xenopus Model Organism Knowledgebase (MOK), an online resource that integrates all genomic and biological data from Xenopus research. Our mission is to accelerate the translation of Xenopus research into knowledge that will improve human health. We aim to empower Xenopus research and enhance the impact of Xenopus data in the broader biomedical community, as animal models, such as Xenopus, are essential for biomedical research and have led to a wealth of discoveries. Xenbase is user-friendly, allowing investigators to quickly find and link different data types in ways that would otherwise be difficult, time consuming, or impossible. It provides high quality curation, data integration, and bioinformatics tools to link Xenopus data to humans and other model organisms, NCBI, UniProt, Ensembl and other resources. In this post genomic era, with thousands of scientific publications annually, and the exponential growth of “omic” datasets, Xenbase is essential to translate the enormous amount of data generated from research using Xenopus into meaningful connected data. Xenbase, thus, plays an essential role in maximizing NIH’s >$120 million annual investment in Xenopus research. Xenbase is an essential resource for hundreds of labs around the world. There is a clear need to continue curating Xenopus data, to develop new tools to keep up with technological advances, and link Xenopus data to human biology in novel and insightful ways. Many of the letters of support (more than 110) state that labs could not function without Xenbase, and renewed funding for Xenbase was identified as the top priority in the 2020 Xenopus research community white paper.

组成部分：总体 项目总结/摘要 Xenbase是Xenopus模式生物知识库（MOK），一个在线资源， 整合了爪蟾研究的所有基因组和生物学数据。我们的使命是 将非洲爪蟾的研究成果转化为能够改善人类健康的知识。我们的目标是 授权非洲爪蟾研究，并增强非洲爪蟾数据在更广泛的生物医学领域的影响力。 社区，作为动物模型，如非洲爪蟾，是必不可少的生物医学研究， 带来了大量的发现Xenbase是用户友好的，使调查人员能够快速 以其他方式查找和链接不同的数据类型是困难的，耗时的，或 不可能的它提供了高质量的策展，数据集成和生物信息学工具， 非洲爪蟾数据到人类和其他模式生物，NCBI，UniProt，Ensembl和其他 资源在这个后基因组时代，每年有成千上万的科学出版物， 随着“omic”数据集的指数增长，Xenbase对于翻译大量的 从使用Xenopus的研究中产生的数据转化为有意义的连接数据。Xenbase， 因此，在最大限度地提高NIH在非洲爪蟾上的1.2亿美元年度投资方面发挥了重要作用 research. Xenbase是全球数百个实验室的重要资源。有一个 明确需要继续管理爪蟾数据，开发新的工具，以跟上 技术进步，并以新颖而有见地的方式将非洲爪蟾的数据与人类生物学联系起来。 许多支持信（超过110封）指出，实验室不能没有 Xenbase，并将为Xenbase重新提供资金确定为2020年的首要任务 非洲爪蟾研究社区白色纸。