Predoctoral Training in the Pharmacological Sciences

药理学博士前培训

• 批准号: 10405531
• 负责人: Michael James Emanuele
• 金额: $ 52.04万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10405531
• 关键词: Pharmacology; Science; Training; pre-doctoral

The mission of the Pharmacological Sciences Training Program (PSTP) is to train outstanding scientists in the pharmacological sciences, enabling them to transition to any of the varied career opportunities in the U.S. biomedical research enterprise. A highly productive and well-funded faculty provide a diversity of research areas for trainees that builds on our traditional strengths in receptors and signal transduction, cancer and protein kinases, and neuropharmacology with emerging areas in chemical biology, nanotechnology, genomics and proteomics, stem cells, RNA biology, bioinformatics and systems biology. Students apply to the Biological and Biomedical Sciences Program (BBSP), an admissions portal/first year program for 14 degree-granting departments, an umbrella program that oversees recruitment and training of first-year graduate students in the biomedical sciences. The BBSP admits between on average 75-90 students per year, with an increase to 100 students slated for 2019. A significant portion (20-25%) of matriculating students are underrepresented in the biomedical sciences. Students carry out three research rotations, take a required first year course and another course of their choosing, and, at the end of their first year, select a thesis mentor and a degree-granting PhD program for their thesis research. Students joining the PSTP choose from 46-core faculty for their dissertation research. A very strong Medical Scientist Training Program (MSTP) also brings in ~10 students per year, 0-2 of which join the PSTP per year. The PSTP is designed around a complementary set of training tools, including formal lecture-based courses, seminar courses focusing on scientific communication skills, an immersive grant-writing course, and original doctoral research. Our rationale is that by combining these training approaches, we prepare our trainees for future success. Introductory and advanced courses in pharmacology and physiology, and elective specialized courses are required during the first and second years. A rigorous and intensive grant-writing course develops skills for identifying an important, innovative and tractable research question and hypotheses and formulating a strong set of Specific Aims that test these hypotheses. Presentation courses and a student seminar series provide students with many opportunities to hone their research presentation skills and gain confidence in public speaking. Quantitative skills are developed through strong emphasis on biostatistics, biocomputation, and ligand- receptor binding theory and analysis. Rigor and reproducibility are emphasized across all training opportunities. Individual Development Plans are drafted for all students, and also are used to identify quantitative skills classes germane to the students’ research projects. A robust advisory system oversees the thesis research years of students. Faculty rely on evidence-based mentoring practices to best help students achieve shared goals. Based on previous years, we anticipate that we will have 9-11 new, training grant-eligible students entering the PSTP program each year. Students will be appointed to the training grant for a maximum duration of two years, during their second and third year of graduate school. The average time-to-degree over the last five years for all PSTP students, including trainees from underrepresented groups, is 5.5 years, and these students had on average 4 publications, a little less than two of which were first-author publications. Twenty-three percent of current PSTP trainees are from underrepresented groups, and three of our current UR trainees were awarded the prestigious HHMI/Gilliam Fellowship for Advanced Study. Our overall goal is to train a diverse cohort of future scientists by equipping them with critical-thinking, computational, and communication skills and providing exposure to myriad career opportunities needed to obtain a position in a scientific career of their choosing.

药理学科学培训计划（PSTP）的使命是培养药理学科学领域的杰出科学家 药理学科学，使他们能够过渡到美国任何不同的职业机会 生物医学研究企业。高产且资金充足的教师队伍提供了多样化的研究领域 为学员提供基于我们在受体和信号转导、癌症和蛋白质方面的传统优势的培训 激酶和神经药理学以及化学生物学、纳米技术、基因组学和新兴领域 蛋白质组学、干细胞、RNA 生物学、生物信息学和系统生物学。学生申请生物和 生物医学科学项目 (BBSP)，一个招生门户/一年级项目，可授予 14 个学位 部门，一个伞式计划，负责监督一年级研究生的招募和培训 生物医学科学。 BBSP 每年平均招收 75-90 名学生，目前已增至 100 名 预计 2019 年入学的学生。很大一部分 (20-25%) 的入学学生在 生物医学科学。学生进行三次研究轮转，参加第一年必修课程和另一门课程 他们选择的课程，并在第一年结束时选择一位论文导师和一位授予学位的博士 他们的论文研究计划。加入 PSTP 的学生从 46 名核心教师中选择撰写论文 研究。非常强大的医学科学家培训计划 (MSTP) 每年还招收约 10 名学生，其中 0-2 名 每年加入 PSTP。 PSTP 围绕一套互补的培训工具而设计，包括正式的讲座课程、 专注于科学沟通技巧的研讨会课程、沉浸式资助写作课程和原创课程 博士研究。我们的理由是，通过结合这些培训方法，我们为学员做好了准备 未来的成功。药理学和生理学的入门课程和高级课程，以及选修专业课程 第一年和第二年需要课程。严格而密集的资助写作课程的开发 识别重要的、创新的和易于处理的研究问题和假设并制定研究计划的技能 测试这些假设的一组强有力的具体目标。演示课程和学生研讨会系列 为学生提供许多机会磨练他们的研究演示技能并获得公众的信心 请讲。定量技能是通过强调生物统计学、生物计算和配体来发展的。 受体结合理论和分析。所有培训机会都强调严谨性和可重复性。 为所有学生起草个人发展计划，也用于确定定量技能课程 与学生的研究项目密切相关。强大的咨询系统监督论文研究年 学生。教师依靠基于证据的指导实践来最好地帮助学生实现共同目标。基于 与往年相比，我们预计将有 9-11 名符合培训补助金资格的新学生进入 PSTP 每年的计划。学生将被指定获得最长两年的培训补助金，期间 他们在研究生院的第二年和第三年。过去五年所有 PSTP 获得学位的平均时间 学生（包括来自代表性不足群体的学员）的学龄为 5.5 年，这些学生平均有 4 年 出版物，其中不到两篇是第一作者出版物。当前 PSTP 的 23% 学员来自代表性不足的群体，我们目前的三名 UR 学员被授予享有盛誉的 HHMI/吉列姆高级研究奖学金。我们的总体目标是通过以下方式培养多元化的未来科学家 为他们提供批判性思维、计算和沟通技能，并让他们接触无数的知识 在他们选择的科学职业中获得职位所需的职业机会。