Generation of robust resident memory T cells in barrier tissues through skin vaccination

通过皮肤疫苗接种在屏障组织中生成强大的常驻记忆 T 细胞

• 批准号: 10408492
• 负责人: Rachael Ann Clark
• 金额: $ 44.38万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-07 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408492
• 关键词: 2019-nCoV; Antibodies; COVID-19; Cells; Disease; Epidemic; Future; Generations; Human; Immunity; Lung diseases; Middle East Respiratory Syndrome; Patients; Severe Acute Respiratory Syndrome; T memory cell; T-Lymphocyte; Tissues; Vaccines; Virus; base; betacoronavirus; design; novel strategies; respiratory pathogen; skin vaccination; vaccine delivery

SUMMARY COVID 19, the lower respiratory disease caused by the 2019 nCov virus, is the latest betacoronavirus to cause epidemic disease in humans. Previously, SARS and MERS, both cause by related viruses, emerged and fell dormant as epidemics. Betacoronaviruses use homologous “Spike” proteins to bind mammalian cells for entry and infection, and most vaccines are being built to generate neutralizing antibodies to the unique 2019 nCov Spike protein. In contrast, we are trying to create a “universal” betacoronavirus vaccine base on T cell immunity, using proteins conserved between all known coronaviruses as immunogens. These proteins, expressed by MVA vectors and delivered by epidermal disruption, should provide broad and durable pulmonary immunity to past, present, and future betacoronavirus threats.

总结

项目成果

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis.

• DOI: 10.1038/s41586-021-04384-4
• 发表时间: 2022-03
• 期刊: Nature
• 影响因子: 64.8

CD1a selectively captures endogenous cellular lipids that broadly block T cell response.

CD1A选择性地捕获了广泛阻断T细胞反应的内源性细胞脂质。

• DOI: 10.1084/jem.20202699
• 发表时间: 2021-07-05
• 期刊: The Journal of experimental medicine
• 作者: Cotton RN;Wegrecki M;Cheng TY;Chen YL;Veerapen N;Le Nours J;Orgill DP;Pomahac B;Talbot SG;Willis R;Altman JD;de Jong A;Van Rhijn I;Clark RA;Besra GS;Ogg G;Rossjohn J;Moody DB
• 通讯作者: Moody DB

Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin.

• DOI: 10.1038/s41467-020-19383-8
• 发表时间: 2020-11-05
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Dyring-Andersen B;Løvendorf MB;Coscia F;Santos A;Møller LBP;Colaço AR;Niu L;Bzorek M;Doll S;Andersen JL;Clark RA;Skov L;Teunissen MBM;Mann M
• 通讯作者: Mann M