Southwest Health Equity Research Collaborative

项目总结 SHERC的总体目标是将NAU的基础生物医学、临床和行为研究增加到 解决美国西南部不同人群之间的健康差距。在前5年， 我们将在强大的基础上，提高环境和社区卫生领域的研究能力 NAU的研究基地。随着时间的推移，SHERC将与社区合作伙伴密切合作，扩大容量，以 解决慢性病和传染病方面的健康差距，以及高度优先的行为健康 条件，由社区合作伙伴决定。SHERC由五个核心组成，所有这些核心都是协同作用的。 SHERC的每个核心都为单独的创新提供了明确的机会；它们结合在一起， 在创新方面表现出显著的影响力。行政核心与循证相结合 组织理论，经过测试但新颖地使用了项目评估的“持续改进”模型 和反馈。研究基础设施核心将专注于SHERC的基础设施改善 基础研究、信息学、临床和社区参与的科学计划。此外，它还将需要一个 在改善生物医学、临床和社区卫生领域的跨学科科学工作中的领导作用 整个北大西洋公约组织的科学倡议。调查员开发核心将支持早期开发 北卡罗来纳大学基础生物医学、行为和临床科学的职业研究人员通过两个创新的 计划：支持教师的试点项目计划(PPP)和博士后奖学金计划(PSP) 支持和指导博士后研究人员。社区参与核心使用创新的四个- 将代表#年共同和独特的健康决定因素的调查和行动指导框架 亚利桑那州。这五个研究项目包括以下创新研究：皮尔逊的研究项目将 定义和对比金黄色葡萄球菌携带和流通的基因类型与临床基因和感染 流行率，以更好地了解社会互动如何影响传播。凯勒和普罗珀试图 加强环境污染物与临床并发症关系的研究现状 比如无法愈合的慢性伤口。Varadaraj的研究将利用肿瘤中的细胞适应，以 确定在这种状态下改变纤维形成是否会将癌前细胞转变为恶性细胞 侵袭前细胞是否会变得侵袭。 纳伦的书房 具有改进和扩展的潜力 呼肠孤病毒为基础的癌症疗法。 福福纳夫的研究 可能会识别具有更多口腔微生物组的个体 易患早期儿童龋齿(ECC)或具有特殊致病株变形链球菌和 远缘链霉菌S.sobrinus.

PROJECT SUMMARY The overall goal of SHERC is to increase basic biomedical, clinical, and behavioral research at NAU to address health disparities among diverse populations of the Southwestern United States. In the first 5 years, we will increase research capacity in the areas of environmental and community health, building on a strong research base at NAU. Over time, SHERC will work closely with community partners to expand capacity to address health disparities in chronic and infectious diseases, as well as high-priority behavioral health conditions, as determined by community partners. SHERC consists of five cores that all interact synergistically. Each of the SHERC cores provides a clear opportunity for innovation individually; in combination, they demonstrate significant impact in innovation. The Administrative Core combines evidence-based organizational theory with a tested but novel use of a “continuous improvement” model of program assessment and feedback. The Research Infrastructure Core will focus on infrastructure improvement for the SHERC basic research, informatics, clinical, and community engaged science programs. In addition, it will take a leadership role in improving the interdisciplinary science efforts in biomedical, clinical, and community health science initiatives throughout NAU. The Investigator Development Core will support the development of early career investigators in basic biomedical, behavioral, and clinical sciences at NAU through two innovative programs: a Pilot Project Program (PPP) to support faculty and a Postdoctoral Scholar Program (PSP) to support and mentor postdoctoral researchers. The Community Engagement Core uses an innovative four- direction Framework for Inquiry and Action that will represent the shared and distinct determinants of health in Arizona. The five Research Projects include the following innovative studies: Pearson's research project will define and contrast S. aureus carriage and circulating genotypes with clinical genotypes and infection prevalence to better understand how social interactions impact transmission. Kellar and Propper seek to enhance current research on the relationship between environmental contaminants and clinical complications such as non-healing chronic wounds. The Varadaraj study will exploit a cellular adaptation in tumors, to determine whether altering fibrillogenesis in such states will switch premalignant cells to malignant cells and whether preinvasive cells would become invasive. Naren's study has the potential to improve and extend reovirus based cancer therapies. Fofonav's study may identify individuals with an oral microbiome that is more susceptible to early childhood caries (ECC) or individuals with particularly pathogenic strains of S. mutans and S. sobrinus.